Sentences with phrase «activity of this protein»

The technique, called activity - based protein profiling, has been used in cancer research and allows researchers to track the actual activities of proteins operating within a cell.

The newly uncovered pathway depends on activity of a protein called FER, a member of a family of proteins (called non-receptor tyrosine kinases) that add phosphate groups to other proteins.

Recognizing that fibrinogen can kick - start the chain reaction that leads to inflammation and myelin damage, Akassoglou and her team are now looking at ways to target the harmful activities of the protein in the brain without affecting its function in the blood.

Coordinated activities of protein kinases and protein phosphatases ensure phosphorylation homeostasis and amplitude of signaling response, and understandably its imbalance is linked to diseases, such as cancer.

Also, the RAF1 variants increased activity of the protein mTOR, which can be inhibited with several drugs already approved by the FDA.

The new findings suggest that GLRs rely on another group of proteins, called «cornichon» proteins, to shuttle GLRs to different locations in plant cells and to regulate activity of the protein within each cell.

Stability of Antiradical Activity of Protein Extracts and Hydrolysates from Dry - Cured Pork Loins with Probiotic Strains of LAB

It was previously shown by others that a rare disease called generalized pustular psoriasis (in which the skin erupts into pustules) was caused by a genetic mutation that resulted in unrestrained activity of a protein normally produced in our skin, called IL - 36.

«So we could use this material and measurement technique for locally probing nanoscale activity of proteins that exists in cell membrane with high sensitivity.»

But their results were surprising because samples that were less acidic, closer to the neutral pH of pure water, showed higher activity of the protein siderocalin and were better at restricting bacterial growth than the more acidic samples.

However, Sakai's research team has discovered sites within the protein sequence that are extremely specific for controlling different activities of the protein.

«This is quite good and convincing work that confirms host defense activity of amyloid - β against fungal and bacterial infections in animal models, and begins to unravel the mechanisms of antimicrobial activity of the protein,» said Kevan Hartshorn who studies innate immunity at the Boston University School of Medicine and was not involved in the study.

This process removed the interrupting insertion and restored the RNA - cutting activity of the protein.

In a new study from the laboratory of Gladstone Investigator Katerina Akassoglou, PhD, scientists reveal in animal models that the heightened activity of a protein called thrombin in the brain could serve as an early indicator of MS.. By developing a fluorescently labeled probe specifically designed to track thrombin, the team found that active thrombin could be detected at the earliest phases of MS — and that this active thrombin correlates with disease severity.

Most of them have one thing in common, according to Dr. Sinisa Dovat, associate professor of pediatrics: impaired activity of a protein called Ikaros that prevents the development and progression of leukemia.

Finally, we are delineating the innate immune signaling pathways governing the antiviral restriction activities of the protein SAMHD1.

Amino acid composition, molecular weight distribution and antioxidant activity of protein hydrolysates of soy sauce lees.

Using small - molecule inhibitors to eliminate the activity of the proteins produced by the bird - specific, median signaling zone in chicken embryos, the researchers were able to induce the ancestral molecular activity and the ancestral anatomy.

It seems that the activities of these proteins are increased at the L3 to L4 transition, so the proteins are likely to have key functions at this time.

The drug suppresses the activity of the protein mGluR5, thought to play a role in altering brain cell structure in patients with fragile X syndrome (SN: 6/2/12, p. 17).

In this case, the scientists designed DNA circuits that controlled the activity of a protein that was responsible for conversion of the prodrug into its active form.

In this way, the team identified a new small protein, growth inhibitor gene product (Gp) 0.6, which specifically targets and inhibits the activity of a protein essential to bacterial cells.

The inhibitor was found to cripple the activity of a protein vital to bacterial cells — a protein that maintains the bacterial cell structure.

Mangelsdorf's team suspected that the drug enhanced the activity of a protein in the intestines.

The researchers hypothesized that if the production or activity of the protein could be inhibited, this might lead to a new therapeutic approach.

Now Ahern has discovered that some drugs used to put patients to sleep may also increase postoperative pain from the procedure itself by boosting the activity of a protein called TRPA1 on the surface of pain - sensing nerve cells.

Chronic activation of these autoreceptors revs up the activity of protein kinase A (PKA).

The main function of Ppm1f is to regulate the activity of the protein Camk2 (Calmodulin - dependent protein kinase 2), which is key in many processes of the human body such as memory, the heart's functioning and the immune system.

«It's not known how that affects that activity of the protein,» Abmayr says.

They believe that drugs could be developed that would reduce or stop the activity of the protein that is causing damage and preventing the antioxidant response from occurring.

«It's an exciting finding, as we were able in experiments to reverse the symptoms of the disease by targeting the activity of these proteins.»

In doing so, they discovered that reducing the activity of a protein known as IFI16 inhibited pyroptosis, explained Zhiyuan Yang, PhD, a Gladstone postdoctoral fellow who is one of the paper's two lead authors.

In contrast, CX546 increases nerve cell activity and calcium influx into nerve cells by enhancing the activity of proteins called AMPA (α - amino -3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors.

They showed that Sestrin1 exerts its anti-tumor effects by blocking the activity of a protein complex called mTORC1, which is well known for controlling protein synthesis as well as acting as a sensor for nutrient or energy changes in the cell.

The team also made the surprising discovery that when grizzlies are most obese, they are also the most insulin sensitive (or least diabetic), and they become this way by shutting down the activity of a protein called PTEN in fat cells.

«Kinases add a phosphate group to other proteins and this addition is like flipping a switch; it modifies the activity of the protein,» said Dr. Choel Kim, assistant professor in pharmacology and the Verna and Marrs McLean Department of Biochemistry and Molecular Biology at Baylor, and senior author of this report.

Activity of this protein affects the function of the striatum — the part of the brain that's involved in reward learning and motivation.

In a paper published by Scientific Reports today, the research team found the activity of this protein, called PTEN (for Phosphatase and tensin homolog deleted on chromosome 10), is different between men and women.

It's long been known that obese men are more likely to develop type two diabetes than obese women, but researchers at McMaster University have discovered it may be related to a difference between the sexes in the activity of a protein in the muscle.

As the name suggests, kinase inhibitors interrupt the function of kinases — a particular type of enzyme — and effectively shut down the activity of proteins that contribute to cancer.

UNC0638 and UNC0642 work by inhibiting the activity of a protein called G9a, which together with other proteins packs the maternal genes tightly in the chromosome.

By inhibiting the activity of this protein, the scientists found they could disrupt the associated memories that pull alcoholics back off the wagon.

Loss of hearing is linked to a decrease in a critical cellular protein, and elevating the activity of this protein could prevent noise - induced hearing loss, as well as potentially benefiting a host of other aging - related conditions

The scientists showed that NR and NAD + prevent hearing loss by increasing the activity of the protein sirtuin 3 (SIRT3), which is critically involved in the function of mitochondria, the powerhouses of the cell.

A new study by Dr. Norman Greenberg challenges the idea that prostate cancer can be treated successfully by blocking the activity of a protein called insulin - like growth factor, or IGF - 1.

The implication: It is not just the active site that is important for determining the activity of a protein.