Sentences with phrase «acts as a tumor suppressor»

EDD1 is an E3 ubiquitin ligase involved in degrading cellular proteins, while TIP60 act as a tumor suppressor protein, and can both be found in the human body.

Rb acts as a tumor suppressor.

Now, results of a new study by Johns Hopkins Kimmel Cancer Center scientists suggests a powerful role for the protein in normal breast cells, acting as a tumor suppressor that halts abnormal cell growth.

«HOXA5 protein acts as tumor suppressor in breast cancer, lab cell study shows.»

These findings show that MAX acts as a tumor suppressor gene in one of the more aggressive types of lung cancer.

The current discovery that MAX acts as a tumor suppressor in lung cancer provides evidence that an aberrant SWI / SNF - MYC / MAX network is essential for lung cancer development.

MicroRNA 218 acts as a tumor suppressor by targeting multiple cancer phenotype - associated genes in medulloblastoma.

Thirteen tumors had two non-silent MAP3K1 mutations (biallelic loss), and most of the mutations are highly deleterious (nonsense, frameshift, etc.) suggesting that this gene may act as a tumor suppressor.

Thus, our results demonstrate that Rassf1A acts as a tumor suppressor gene.

Hence, p21waf1 / cip1 acts as a tumor suppressor.

In 1989, Bert Vogelstein, MD, a titan in the field of cancer genomics, discovered that p53 acts as a tumor suppressor.

Mutations in the NF1 gene cause defects in the neurofibromin 1 protein, which acts as a tumor suppressor.

See: Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β Soy isoflavone genistein has about 4 % of 17β - estradiol's affinity for estrogen receptor α, responsible for estrogen's feminizing effects, and 87 % of its affinity for ERβ, which acts as a tumor suppressor.

Not exact matches

Their finding — that the presence of high levels of NF - κB in lung cancer tumors can act as a suppressor — provides new insight into how tumor pathways regulate the anti-tumor response.

In response to cellular stress such as DNA damage, oncogene activation, transcriptional inhibition, and hypoxia, tumor suppressor p53 is activated and expressed, and acts as a transcription factor to induce its target genes [1], thereby playing a central role in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4].