Sentences with phrase «acts as tumor»

Studies have found it increases the activities of macrophages, T lymphocytes and natural killer cells and that it acts as a tumor inhibitor.

See: Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β Soy isoflavone genistein has about 4 % of 17β - estradiol's affinity for estrogen receptor α, responsible for estrogen's feminizing effects, and 87 % of its affinity for ERβ, which acts as a tumor suppressor.

Mutations in the NF1 gene cause defects in the neurofibromin 1 protein, which acts as a tumor suppressor.

In 1989, Bert Vogelstein, MD, a titan in the field of cancer genomics, discovered that p53 acts as a tumor suppressor.

Hence, p21waf1 / cip1 acts as a tumor suppressor.

Thus, our results demonstrate that Rassf1A acts as a tumor suppressor gene.

MicroRNA 218 acts as a tumor suppressor by targeting multiple cancer phenotype - associated genes in medulloblastoma.

The current discovery that MAX acts as a tumor suppressor in lung cancer provides evidence that an aberrant SWI / SNF - MYC / MAX network is essential for lung cancer development.

These findings show that MAX acts as a tumor suppressor gene in one of the more aggressive types of lung cancer.

«HOXA5 protein acts as tumor suppressor in breast cancer, lab cell study shows.»

Rb acts as a tumor suppressor.

EDD1 is an E3 ubiquitin ligase involved in degrading cellular proteins, while TIP60 act as a tumor suppressor protein, and can both be found in the human body.

Now, results of a new study by Johns Hopkins Kimmel Cancer Center scientists suggests a powerful role for the protein in normal breast cells, acting as a tumor suppressor that halts abnormal cell growth.

In their previous work, the scientists suspected that C / EBPα may act as a tumor suppressant in normal cells, but the mechanism by which its absence promoted lung cancer tumors remained unclear.

Thirteen tumors had two non-silent MAP3K1 mutations (biallelic loss), and most of the mutations are highly deleterious (nonsense, frameshift, etc.) suggesting that this gene may act as a tumor suppressor.

There is also the possibility of a genetic cause involving the p53 gene and an Rb gene which normally act as tumor suppresser genes and for some reason are altered preventing their usual functioning.

Not exact matches

Similar to capsaicin, tumor necrosis factor is suspected to both induce and reduce cancer cell growth, and was shown to commit cells to survival when stimulating EGFR transactivation mechanisms, indicating that EGFR could act as a molecular switch determining the antiapoptotic effect of tumor necrosis factor (50).

In contrast, treatment with only capsaicin or vehicle did not induce any skin tumors in either TRPV1 / WT or KO mice (Table 1; Fig. 1C), indicating that capsaicin alone does not act as a carcinogen.

For some years now, a new class of drugs called antibody - drug conjugates (ADCs) have been used, which work in two ways: they consist of an antibody that binds selectively to the tumor cell receptor and interrupts the signal to propagate; they also act as a transport vehicle for a chemical substance that enters the cancer cells with the antibody and triggers their death.

«For this purpose we have created molecules which act as an adapter between the virus and the tumor cell,» explains Markus Schmid, first author of the study.

To begin the research, the scientists screened human DIPG tumor cultures for surface molecules that could act as targets for CAR - T cells.

After more than six years of research, the research team led by María Soengas, head of CNIO's Melanoma Group, showed that RAB7 acts as an orchestra director, determining the fate of melanoma cells: at high concentrations of RAB7, cellular autodigestion is very active, and this allows tumor cells to obtain energy, prevent the accumulation of toxic components and thus divide and proliferate; when RAB7 is reduced, cells use endosomes to recycle metastatic proteins, favouring their dispersal throughout the body.

A tumor - suppressing protein acts as a dimmer switch to dial down gene expression.

Their finding — that the presence of high levels of NF - κB in lung cancer tumors can act as a suppressor — provides new insight into how tumor pathways regulate the anti-tumor response.

But when TNF lingers as a chronic, low - level presence in the tumor, it acts very differently.

Researchers from the Vetmeduni Vienna have now discovered that NK cells can switch and promote tumor growth, with STAT5 acting as the key regulator.

Andrechek's federally funded study looked at mice containing all subtypes and compared the makeup of the rodent tumors and the way the genes acted, known as gene expression, to human tumor data.

Looking forward, Gimi's work will focus on using these microencapsulated cells to stimulate the immune system to act against tumors, as well as activating drug synthesis.

«This peptide acts as a «zip code» in that it enables the binding of the nanoparticles only to blood vessels within the tumor and not normal blood vessels,» says Alnawaz Rehemtulla, a radiologist and environmental health scientist who co-authored the study.

«Instead of administering a cancer vaccine to destroy tumors, we hope to modify the immune system to allow the patient's own tumor to act as a cancer vaccine,» said Hyung Lae Kim, MD, co-medical director of the Urologic Oncology Program and lead author of the study.

In addition, Sox9 acts also as key orchestrator of the extracellular matrix remodeling, cell adhesion and cytoskeleton dynamics required for tumor invasion.

Known as a PARP inhibitor, the drug acts on a defect in the DNA repair mechanism in the brain tumor cells, they said.

The findings, published online the week of March 21 in the journal Proceedings of the National Academy of Sciences, demonstrate that nanoparticle - based therapies can act as a «precision medicine» for targeting tumors while leaving healthy tissue intact.

Quiescent PSCs in a normal pancreas act as lipid - storing cells with a limited secretome, whereas activated PSCs in the tumor microenvironment produce a vast array of secreted proteins implicated in cancer progression.

In addition, it was increasingly recognized that oncolytic viruses not only were able to directly lyse cancer cells, but they also «freed «tumor specific neoantigens, indirectly acting as a cancer vaccine.

Drs. Colleen Delaney, Harlan Robins named 2016 Leaders in Health Care; Hutch study finds CMV viral load can act as surrogate endpoint for clinical trials; A new target for Tumor Paint: BLZ - 100 lights up head and neck cancers; Dr. Stephen Tapscott appointed to NIAMS advisory council

An initial payload of CD8 cells breaks down the tumor, and the HSC - derived CD4 cleans up the remaining cells and acts as protection against the recurrence of any cancer cells expressing NY - ESO - 1.

The removed gene region thus appears to act as an important gene switch promoting cancer, and without it tumors develop much more rarely.

In response to cellular stress such as DNA damage, oncogene activation, transcriptional inhibition, and hypoxia, tumor suppressor p53 is activated and expressed, and acts as a transcription factor to induce its target genes [1], thereby playing a central role in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4].

Using a model where K - ras acts as an oncogene and initiates tumor formation, mice that were bred to not have Notch1 function showed an almost uniform distribution of about two cancerous lesions per mouse after 6 weeks, compared with approximately 14 tumors / mouse for those with Notch1 function still remaining.

It is known to protect our body by acting as a strong free radical scavenger and a powerful tumor growth suppressant.

despite its controversy in mainstream medicine that antioxidants counteract chemotherapy, at the high concentrations achieved intravenously, vitamin C acts as a prooxidant and is toxic to tumor cells.

Continuing research suggests that astragalus boosts immunity, acts as an anti-inflammatory, aids in the proper regulation of insulation and related illnesses, can slow tumor growth and protects the cardiovascular system.

Epigallocatechin -3-gallate (EGCG) found in green tea even acts as an antiangiogenic and antitumor agent, and helps modulate tumor cell response to chemotherapy.30

Polyunsaturated fats such as corn oil and soybean oil are highly unstable and vulnerable to oxidation — and oxidation, in turn, is linked to cancer — while the omega - 6 fatty acids that predominate in vegetable oils have been shown to accelerate the growth of tumor cells.6 As Fallon and Enig explain, 4 excessive consumption of toxic polyunsaturated oils — not red meat — represents a known mechanism for colon cancer: «Colon cancer occurs when high levels of dietary vegetable oils and hydrogenated fats, along with certain carcinogens, are acted on by certain enzymes in the cells lining the colon, leading to tumor formation» [Emphasis addedas corn oil and soybean oil are highly unstable and vulnerable to oxidation — and oxidation, in turn, is linked to cancer — while the omega - 6 fatty acids that predominate in vegetable oils have been shown to accelerate the growth of tumor cells.6 As Fallon and Enig explain, 4 excessive consumption of toxic polyunsaturated oils — not red meat — represents a known mechanism for colon cancer: «Colon cancer occurs when high levels of dietary vegetable oils and hydrogenated fats, along with certain carcinogens, are acted on by certain enzymes in the cells lining the colon, leading to tumor formation» [Emphasis addedAs Fallon and Enig explain, 4 excessive consumption of toxic polyunsaturated oils — not red meat — represents a known mechanism for colon cancer: «Colon cancer occurs when high levels of dietary vegetable oils and hydrogenated fats, along with certain carcinogens, are acted on by certain enzymes in the cells lining the colon, leading to tumor formation» [Emphasis added].

«Besides affecting tumor cells» directly, phytates «can act on [our] immune functions» by augmenting natural killer cell activity, the cells in our body that hunt down and dispose of cancer cells, as well as neutrophils, which help form our «first line of defense.»

It may help protect against tumor development as well as act as a block enzymes associated with cancer, according to an article in Cancer Letters journal.

There are many different types of brain tumors, some act as space occupying lesions and other are functional such as pituitary tumors causing Cushing's disease.