Sentences with phrase «acute effects produced»

Not exact matches

Remarkably, the same healing effect was produced when B cells from older obese diabetic mice were applied to acute wounds in similarly aged, obese diabetic mice.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Whether from unknown sources, or chronic or acute pain from an injury or illness, the presence of pain itself can produce muscle imbalance maintaining a vicious cycle of cause and effect.

A runner's stretch can produce an acute analgesic effect which may reduce pain mediated muscular inhibition in someone with an injury.

While most newer NSAIDs are effective in treating acute and chronic pain, all of these drugs have the potential to produce occasional and sometimes severe side effects in your dog.

Human exposure to fine particulate matter increases the risk of acute lower respiratory infection, chronic obstructive pulmonary disease, heart disease, stroke and lung cancer, while exposure to carbon dioxide — a colorless, odorless, non-toxic gas — produces none of these effects and is in fact essential for life on earth.