It binds to lipopolysaccharides (LPSs) from Gram - negative bacteria and intestinal enterocytes, initiating a chain of events that alert
the adaptive arm of the immune system.
When the dendritic cells are activated, they train T cells — their allies in
the adaptive arm of the immune system — to attack cancer cells anywhere in the body, whether at the site of the original tumor or distant metastases.
This 2 - decade - old idea, called the hygiene hypothesis, suggests that lack of exposure to dangerous parasites in childhood makes
the adaptive arm of the immune system more likely to overreact when it comes into contact with benign allergens.
T cells, along with B cells and others, comprise
the adaptive arm of the immune system, the body's second line of defense which quickly attacks and «remembers» specific pathogens.
Up until now, efforts in generating a vaccine against TB have been mainly focused on T cells (cells from
the adaptive arm of our immune response with memory capacity), with very disappointing outcomes in both pre-clinical as well as clinical trials.
GM - CSF also promotes an inflammatory environment for
the adaptive arm of the immune system, especially in Th17 cell biology [64, 65].
Unlike conventional T cells, which belong to
the adaptive arm of the immune response and take a few days before they are fully trained on a single, specific protein fragment or peptide antigen, MAIT and iNKT cells recognize molecular components common to many microbes.
The macrophages release cytokines that can activate more innate immune cells, readying them for attack on viruses or cancer cells, or they can activate
the adaptive arm of immunity, priming it for clonal expansion.