Dr. Locksley's laboratory focuses on tracking cytokine expression in model systems, as a mechanism to investigate complex functional interactions between innate and
adaptive cells in the immune system.
Not exact matches
When the dendritic
cells are activated, they train T
cells — their allies
in the
adaptive arm of the
immune system — to attack cancer
cells anywhere
in the body, whether at the site of the original tumor or distant metastases.
The rapid drop
in circulating T
cells during sleep «show [s] that even one night without sleep affects the
adaptive immune system,» says first author Luciana Besedovsky.
The researchers are investigating an
adaptive immune system, termed CRISPR - Cas, which is found
in half of all bacterial species and
in almost all single -
celled microbes
in the archaea domain.
With respect to biological applications, the group is focusing on how cellular heterogeneity and
cell - to -
cell communication drive ensemble - level decision - making
in the
immune system, with an emphasis on «two - body» interaction (e.g., host
cell - virus interactions, innate
immune control of
adaptive immunity, tumor infiltration by
immune cells).
Our laboratory is interested broadly
in the interface between the innate and
adaptive immune systems, and the unique subsets of T lymphocytes that bridge these
systems by adopting properties that are very characteristic of innate
immune cells.
B
cells (bursal or bone marrow - derived
cells) are lymphocytes that play a pivotal role
in the
adaptive immune system and disruption of B
cell function is a common hallmark of many different diseases.
In the late 1960s, Rowley and his graduate student Donald Mosier were the first to describe the function of a previously unrecognized
cell type, a component of the
adaptive immune system they labeled the «A
cell,» for its «adherent, accessory or antigen - presenting capacity.»
Immune Regenerative Medicine is the field of medicine which encompasses numerous strategies used to improve the body's healing response
in restoring the
cells and function of the innate and
adaptive immune system.
Topics covered will include how the
immune system and commensal microbes interact
in the context of health and disease; how dendritic
cells respond to infectious or inflammatory stimuli and the roles they play
in the induction and polarization of
adaptive immune responses against pathogens; how the innate
immune pathways regulate inflammation at mucosal barrier tissue sites and how the macrophages are involved
in intestinal inflammation.
For HIV to develop into full - blown AIDS, the virus must deplete a subset of
immune cells called CD4 + T
cells, disabling an infected person's
adaptive immune system in the process.
GM - CSF also promotes an inflammatory environment for the
adaptive arm of the
immune system, especially
in Th17
cell biology [64, 65].
The strict limit
in proliferative potential of normal human somatic
cells - a process known as replicative senescence - is highly relevant to the
immune system, because clonal expansion is fundamental to
adaptive immunity.
Zebrafish have both an innate and
adaptive immune system with the full repertoire of
immune and inflammatory
cells found
in mammalian
systems.
The
adaptive immune system is a more advanced, sophisticated part of the
immune system, and miscommunications between
adaptive immune system cells lead those
cells to fight your body's own tissues, creating the villous atrophy seen
in celiac disease.
What ends up happening is IgG
cells from our
adaptive immune system are called
in to attack.