Intermittent fasting, regular exercise and consumption of dietary phytochemicals can have a major positive impact on health by bolster - ing
adaptive cellular stress response pathways that protect against and counteract a range of major diseases.
In particular, the cAMP signaling cascade directs
adaptive cellular responses to a variety of
stress stimuli via a combination of acute affects arising from GS - protein coupled receptor (GPCR)- mediated activation of PKA and long - term affects resulting from transcriptional reprogramming directed by CREB and the CREB Regulated Transcription Coactivators (CTRCs).