Sentences with phrase «adaptive immune responses by»

She also investigates the cellular and molecular mechanisms of innate and adaptive immune responses by RNA vaccines.

FcRn bears an intriguing structural resemblance to molecules called major histocompatibility complex (MHC) proteins, which function in the vertebrate adaptive immune response by presenting antigenic peptides to T cells.

SHP2 also suppresses T - cell activity against growing tumors through regulation of the adaptive immune response by binding to PD - 1 and dephosphorylating CD28 and the protein LCK.

Not exact matches

NKp46 was critical for the subsequent development of antiviral and antibacterial T cell responses, which suggests that the regulation of NK cell function by NKp46 allows for the optimal development of adaptive immune responses.

The UNC research team, led by Lemon and Jason Whitmire, Ph.D., Associate Professor in UNC's Department of Genetics, is now poised to investigate the complicated interplay of nonspecific «innate» and specific «adaptive» immune responses that ultimately control the infection and eliminate HAV from the host — processes that are not well understood for any of the five human hepatitis viruses.

«Our study shows a whole new route, or bypass mechanism, for triggering the body's adaptive immune response to TB infection, a means by which infected dendritic cells cooperate with uninfected dendritic cells to activate T cells and respond to the infection,» says infectious disease specialist and study senior investigator Joel Ernst, MD, a professor at NYU Langone Medical Center.

Following transmission by mosquitoes, the early specific (also called adaptive) immune response to WNV is thought to be dominated by antibodies, and, consistent with this, the researchers found that older mice had less potent WNV - specific antibody responses during the early phase of infection.

Adaptive immune responses are initiated by the clonal selection of naive T lymphocytes, which recognize their cognate ligands through antigen - specific T cell receptors.

Noncytolytic control of viral infections by the innate and adaptive immune response.

By showing that ligands associated with innate immunity enable dendritic cells to initiate T cell responses, this work provided the key missing link between the innate and adaptive immune responses.

Blood is the body's only site in which antigens are not handled by lymph nodes; instead, adaptive immune responses to blood - borne antigens are orchestrated entirely within the spleen.

Recently, the crucial involvement of IRFs in innate and adaptive immune responses has been gaining much attention, particularly with the discovery of their role in immunoregulation by Toll - like receptors and other pattern - recognition receptors.

Both innate and adaptive immune responses are affected by the aging process; however, the adaptive response seems to be more affected.

Evolutionarily conserved molecular patterns on microbes are recognized by Pathogen Recognition Receptors to induce a potent innate immune response and a tailored adaptive immune response.

When accompanied by an antigen in protein form, generation of a strong, antigen - specific adaptive immune response characterized by CD4 T cells.

In addition to playing an important role in regulating body weight by promoting satiety and increasing energy consumption, leptin has been identified as a major proinflammatory cytokine involved in innate and adaptive immune responses (38).