Sentences with phrase «additional clinical studies»

He worked at the Animal Medical Center in New York City from 1995 - 2000 before going to Tufts University for additional clinical studies.

Additional clinical studies will likely begin in 2017, as further information becomes available from continued use of the PET scanner.

However, a few additional clinical studies are still required before this can be done.

Lilly outlined in July a likely multi-year delay for its experimental rheumatoid arthritis drug baricitinib, after the U.S. Food and Drug Administration declined to approve the drug, calling for an additional clinical study.

Not exact matches

The strengths of the study include the ability to compare outcomes by the woman's planned place of birth at the start of care in labour, the high participation of midwifery units and trusts in England, the large sample size and statistical power to detect clinically important differences in adverse perinatal outcomes, the minimisation of selection bias through achievement of a high response rate and absence of self selection bias due to non-consent, the ability to compare groups that were similar in terms of identified clinical risk (according to current clinical guidelines) and to further increase the comparability of the groups by conducting an additional analysis restricted to women with no complicating conditions identified at the start of care in labour, and the ability to control for several important potential confounders.

Searching the Cochrane PCG Register retrieved 30 reports, searching ClinicalTrials.gov retrieved one report, searching the WHO International Clinical Trials Registry Platform (ICTRP) retrieved four, and the PCG search identified two additional reports for included studies (Graffy 2004; Paul 2012).

Melissa Cheyney is Associate Professor of Clinical Medical Anthropology and Reproductive Biology at Oregon State University (OSU) with additional appointments in Public Health and Women's Studies.

Since 2006, she has co-ordinated the review process, written to authors for additional information, managed data for the review, re-extracted data from papers, re-entered data into Review Manager, re-entered data for the included studies section, analysed and interpreted data, and provided a clinical and policy perspective.

These much shorter courses may have additional risks and remain under study in several large U.S. and European clinical trials.

Although the results are encouraging, the authors report limitations to their study and recommend additional investigations related to these and other mTBI biomarkers in blood that will further clarify their utility in clinical management.

In medicine today, physician - scientists and basic scientists supplement support for their research by applying their expertise part time to develop and test commercial products.1 In my own field, vision science, university - based researchers obtain additional funding through clinical and electrophysiologic studies, pathology, imaging, biochemistry, and animal model development performed for pharmaceutical and instrument companies.

Dr. David Brandman, lead author of the study and an engineering postdoctoral researcher at Brown University, said that while additional innovations will help to move implantable BCIs like BrainGate toward clinical availability for patients, this advance of rapid, intuitive calibration is a key one.

Clinical studies face additional hurdles because the plant is listed on Schedule I, the U.S. Drug Enforcement Administration's (DEA's) list of the most dangerous drugs.

In 22 percent of cases, the additional clinical information found in the EHR was rated as «possibly» having a clinically significant impact on the interpretation of the head CT. «This study exemplifies the power of EHR's and their potential impact on patient care and positive outcomes.

The documentation ranges across the whole spectrum of drug development: Investigators» brochures provide information on all that is currently known about the medicine and so need periodic updating; accurate and concise protocols are required to ensure that trials are performed effectively; clinical trial reports (generally from phase II and III studies) present the information gathered from the trials; higher level documents provide summaries of efficacy and safety data from clinical trial programmes; expert reports provide critical interpretation of the results; and response documents clarify any points that are not clear to the regulatory agencies or provide additional analyses or supporting data for any items of concern.

Third, it is not in the interest of the pharmaceutical company to minimize recording of adverse events since determinations must be made about whether to conduct additional expensive clinical studies.

Whilst established to examine possible safety issues with biologic therapies, it provides the opportunity to look at additional benefits beyond the direct effect on disease severity,» explains William Dixon, MD, MRC clinician scientist / senior clinical lecturer and honorary consultant rheumatologist; Arthritis Research UK Epidemiology Unit, The University of Manchester; and an investigator in the study.

Holton and Nigg employed a rigorous study design that involved parental reports, diagnostic interviews, and consensus of two clinical experts to screen for ADHD and additional psychiatric disorders.

The researchers call for additional larger scale, multi-center clinical studies to further confirm the findings and determine the most effective and personalized treatment protocols.

In addition to assessing clinical outcomes in a retrospective cohort of 30,000 children, the researchers studied a prospective cohort of 2,472 children, doing telephone interviews with caregivers to measure outcomes that parents had identified as their highest concerns: adverse drug effects, additional childcare costs, lingering symptoms and missed school days.

Velculescu cautions that medical practice may not change much until additional studies validate their findings, and there are ongoing clinical trials studying the removal of fallopian tubes instead of ovaries in women with cancer - causing, hereditary BRCA1 and BRCA2 mutations.

The long - term analysis of this study followed all participants from the original 5 - month study1 who were still alive and without liver transplant for an additional 6 months, assessing both cognitive and clinical outcomes.

With additional technical improvements related to exam set - up and delivery, the approach is ready for evaluation in larger clinical studies, including multi-center trials.»

In an accompanying editorial, Daniel C. DeSimone, MD, of the Division of Infectious Diseases, and Christopher V. DeSimone, MD, PhD, of the Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, expand on the importance of the study's findings and provide additional insights with more details about S. aureus infections and statin pharmacology, and put these findings into clinical context.

That's where these findings will be directly implemented in additional research, and also in the context of clinical trials,» said Douglas A. Levine, M.D., head of the Gynecology Research Laboratory at Memorial Sloan - Kettering Cancer Center, New York, and a co-leader in the study.

Additional limitations to the traditional approach include: costly failures to replicate positive results in larger trials; difficulty in determining the reasons for negative results; low yield in terms of identifying disease or intervention mechanisms due to an exclusive focus on symptom change and clinical endpoints; and, the expensive and very lengthy practice of first establishing multi-component psychosocial treatments followed by years of «unpacking» studies.

Another collaboration was unfolding among the cancer geneticists, sequencing experts, clinical researchers, and surgical oncologists at Johns Hopkins, MD Anderson, and Baylor College of Medicine to study 32 pairs of head and neck tumor and normal tissue samples by whole - exome sequencing and validate the findings in an additional 88 samples.

Priority for these additional public comment slots will be given to patients with the condition under study and subject - matter experts from the patient advocacy, clinical, and research communities.

«While much additional research must be done to determine the feasibility of this nanoparticle approach as a vision restoration therapy, our results encourage further effort aimed at achieving this critical clinical objective,» said study co-author David Pepperberg, PhD, Searls - Schenk Professor of ophthalmology and visual sciences at UIC.

The protocols for the Phase1 / 2 studies of PEC - Encap and PEC - Direct are approved and additional clinical protocols are under development.

Potential cardioprotection was based on generally supportive data on lipid levels in intermediate outcome clinical trials, trials in nonhuman primates, and a large body of observational studies suggesting a 40 % to 50 % reduction in risk among users of either estrogen alone or, less frequently, combined estrogen and progestin.2 - 5 Hip fracture was designated as a secondary outcome, supported by observational data as well as clinical trials showing benefit for bone mineral density.6, 7 Invasive breast cancer was designated as a primary adverse outcome based on observational data.3, 8 Additional clinical outcomes chosen as secondary outcomes that may plausibly be affected by hormone therapy include other cardiovascular diseases; endometrial, colorectal, and other cancers; and other fractures.3, 6,9

an additional advantage of this approach is that ongoing research and literature papers are discussed providing examples of studies encompassing both laboratory and clinical aspects of translation.

Additional studies are required to replicate these initial findings and to explore their clinical implications.

The results of the study also suggest that heart failure is a significant clinical problem among relatively young reproductive - age women, especially among women with the presence of an additional disease or condition, such as hypertension, Mogos said.

Significant additional preclinical and clinical studies addressing vector transduction efficacy, biodistribution, and toxicity are required before a human in utero gene transfer protocol can proceed.

Yet another study, a meta - analysis of seven clinical trials involving about 1,150 patients with bleeding ulcers, found that higher doses of proton pump inhibitors did not reduce the risk of additional bleeding, need for surgery, or death more effectively than lower doses did.

Additional authors on this study are Lynne M. Ausman, D.Sc., professor at the Friedman School, Huicui Meng, Ph.D., postdoctoral associate in the Cardiovascular Nutrition Lab at the USDA HNRCA, and Hocine Tighiouart, M.S., statistical associate at the Tufts Clinical and Translational Science Institute and clinical assistant professor of medicine at Tufts University School of MClinical and Translational Science Institute and clinical assistant professor of medicine at Tufts University School of Mclinical assistant professor of medicine at Tufts University School of Medicine.

Another clinical study on the bioavailability of curcuminoids investigated the effects of a patented formulation, BCM - 95 ® CG (Biocurcumax ™)-- a highly - absorbent, synergistic blend of curcumin and turmeric essential oil derived from 100 % pure turmeric (with no additional ingredients or cofactors)-- on a human volunteer group.

It is also unclear whether fasting has an impact on CAD and diabetes in minority populations; thus, additional clinical events studies should be performed among minorities.

Again, these clinical impressions are not research and do not carry the weight of well - done studies, but they certainly offer up hope for an additional treatment for pain.

If you believe you have a patient who is eligible for a specific study, or if you would like additional information regarding clinical trials at the Veterinary Medical Center, you can click here to fill out a survey, or contact us directly via e-mail: [email protected].

Additional adverse reactions observed in the clinical studies were itching, decreased activity, diarrhea, inflammation of the skin, redness of the skin, decreased appetite and redness of the ear.

In one additional study, a single BMD that tested «CARRIER» for both the 118G > A and the 52A > T showed clinical signs of DM highlighting the potential for complex mutation interactions.

The following additional clinical observations were reported in the PROZINC field study: vomiting, lethargy, diarrhea or loose stool, cystitis / hematuria, dry coat, hair loss, upper respiratory infection, ocular discharge, abnormal vocalization, black stools and rapid breathing.1

We need to obtain additional clinical samples from this breed that have been diagnosed with RD by the inclusion criteria for this study in order to determine if this allele is also associated with the disease.

For licensure as an associate marriage and family therapist, a master's degree in a program in marriage and family therapy or a program including a master's degree and additional post-master's degreecoursework, both of which programs shall include three courses in marriage and family studies, three courses in marriage and family therapy, three courses in human development, one course in marrige and family therapy ethics, and one course in research, or from any program accredited by the Commission on Accreditation for Marriage and Family Therapy Education, which degree shall have been granted by a recognized educational institution; completion of a one - year practicum in marriage and family therapy under supervision before or after the granting of the master's degree, which practicum shall include 500 hours of direct clinical experience in marriage and family therapy and 100 hours of supervision of such experience; and registration with the board of an acceptable contract for obtaining the post-master's experience under direction and supervision required for licensure as a marriage and family therapist; See code 43 - 10A - 13.»

6 hours of family therapy theory, 9 hours of additional clinical coursework (not including practica), 6 hours of family studies or human development courses, 3 hours of ethics, 3 hours of assessment / psychopathology, 3 hours of research methods or statistics, 3 hours of electives, and 500 hours of supervised clinical practice, preferably under a licensed family therapist or Approved Supervisor.

Additional studies were identified by reviewing evidence and guidelines from National Institute for Health and Clinical Excellence, the Society of Psychotherapy Research and the British Association of Psychotherapy; by searching dissertation abstracts; by hand searches of reference lists and key journals; and through contact with experts in the field.