Sentences with phrase «additional disease in»

Published reports have indicated additional disease in which dietary elements may play a role in pathogenesis.

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

Last weekend, Scott sharply criticized the federal government and lawmakers for dragging their feet in providing resources needed to combat the disease, including 10,000 Zika preparedness kits, mosquito spray and additional manpower to root out the mosquitoes.

The Xarelto partnership is seeking additional approved uses, with trials underway in patients with acute coronary syndrome, and for reduction of major adverse cardiovascular events in patients with heart failure or peripheral artery disease.

Amicus Therapeutics, Inc. (NASDAQ: FOLD) announced the path forward for U.S. regulatory approval for migalastat, including an additional trial in Fabry disease, focused on gastrointestinal (GI) symptoms.

Micro greens are considered to be in the group of what are newly referred to as «functional foods» which are food products that contain particular health promoting or disease preventing properties that are additional to their normal nutritional values.

After completing this training if you are interested in further information regarding concussions, visit the additional resources link to find handy printouts, related articles and supplementary concussion websites such as STOP Sports Injuries and the Centers for Disease Control and Prevention's Head's Up: Concussion in Youth Sports.

After completing this training if you are interested in further information regarding abuse protection, visit the additional resources link to find handy printouts, related articles and access to supplementary abuse websites such as the National Center for Missing & Exploited Kids, Child Help, Centers for Disease Control: Child Maltreatment Prevention and Darkness to Light.

An estimated 12 million people in the United States have food allergies, and an additional 2 million have celiac disease, a disorder in which the body's immune system attacks itself when exposed to gluten, a protein found in wheat, barley and rye.

If there are additional symptoms such as vomiting, diarrhea and / or blood in the child's stools, the child may have a chronic intestinal illness such as Crohn's disease, ulcerative colitis, or celiac disease.

In fact, the celiac positive kids were breastfed on average for 1.4 additional months compared to those negative for the disease.

Of this number, 2.5 million Americans are living with celiac disease but are undiagnosed, putting them in danger of additional long - term health conditions should the disease not be properly diagnosed.

Additional shots are also needed in some cases to offer full immunity to specific diseases (3).

Additional human studies are needed to explore how individual differences in maternal breast milk composition could predispose to intestinal inflammatory conditions, such as allergic disease.

Additional challenges include lasting disparities in smoking rates and chronic disease outcomes, rising STD rates, and persistent elevated rates of tick - borne illnesses compared with the rest of upstate New York.

The Senate minority leader appeared Wednesday on Long Island and in Rockland County to urge the Centers for Disease Control to unlock millions in additional funding included in the recently passed federal budget.

Legislation passed in the wake of that outbreak requires building owners to register their cooling towers with the city, and City Council Speaker Melissa Mark - Viverito said members would now see if there are any additional steps they can take to help guard against future cases of Legionnaires» disease.

«Loose animals can create additional risks of injury and disease to people in the affected area.»

Jaenisch says that the method that identified the single point mutation in SNCA's enhancer could be used to pinpoint additional pathogenic genes for sporadic PD and sift through the GWAS hits for other diseases, including Alzheimer's disease, cancer, diabetes, and multiple sclerosis.

Research in Parkinson's and Huntington's has uncovered additional examples of disease proteins that, when mutated, stymie protein clearance pathways in neurons.

Londoners of the 17th century watched additional waves of disease come in by ship from Holland.

Our data demonstrate the feasibility of targeted gene disruption in multiple rat strains within 4 months time, paving the way to a humanized monoclonal antibody platform and additional human disease models.

Additional analysis of UK Biobank data from 112,338 people of European ancestry revealed that a specific form of rs9349379 known as the G allele, which was present in 36 % of these individuals, was associated with an increased risk of coronary artery disease.

Disease or an injury to the retina also can cause the loss of protective proteins in the cells, resulting in additional cell death.

There was also less than one additional case for every 1,000 women per year for heart disease and for stroke in the hormone - treated women compared with those on placebo.

The task also revealed an additional memory impairment unique to those with very mild Alzheimer's disease, indicating the changes in cognition that result from Alzheimer's are qualitatively different than healthy aging.

For example, in the combined hormone therapy trial, treated 50 - to 59 - year - olds had five additional cases of heart disease and five more strokes per 10,000 women annually compared with the same - aged group on placebo.

They said the key messages from the study were that stroke is a highly preventable disease globally, regardless of age and sex; that the relative importance of modifiable risk factors means there should be development of regional or ethnic - specific primary prevention programs, and that additional research on stroke risk factors is needed for countries and ethnic groups not included in INTERSTROKE.

To compute how additional pollution from ships increases risk of disease for exposed populations, especially those living in coastal communities or along major shipping lanes and far inland in some nations like India, the team incorporated important underlying health information from the World Health Organization and Global Asthma Network.

Although nanobacteria may not cause kidney stone disease, Coe notes additional circumstantial evidence: At least four teams have reported tiny spherical deposits in the calcified plaques that often appear in the kidneys of patients who suffer from kidney stones.

«While many patients with Anti-NMDAR Encephalitis present with isolated psychiatric symptoms, most of these patients subsequently develop, in a matter of days, additional neurological symptoms which help to make the diagnosis of the disease.

A study by investigators at Brigham and Women's Hospital (BWH) published this week in PLOS ONE identifies four factors that may account for sex differences in statin therapy among patients with coronary artery disease (CAD), pointing to interventions and additional research that will be needed to help overcome this sex disparity and reduce cardiovascular risk for women.

Because environmental exposures have not had time to impact IBD progression in children, researchers have a clearer genetic picture of the disease allowing them to pick out additional genes overlooked in adult research, says senior study author Hakon Hakonarson, director of the Center for Applied Genomics at The Children's Hospital of Philadelphia.

«While it is very well accepted that improving cardiovascular health can reduce the risk of stroke and heart attacks, we now believe that drugs aimed at improving cerebrovascular health may be an additional strategy to treating brain diseases in the future.»

Eight additional affected children in six unrelated families were found to also have disease - causing mutations in this gene.

In an extended analysis, the team identified an additional 33 genetic regions that are also involved in several common immune - mediated conditions (celiac disease, Crohn's disease, ulcerative colitis, type 1 diabetes, rheumatoid arthritis, sarcoidosis and psoriasisIn an extended analysis, the team identified an additional 33 genetic regions that are also involved in several common immune - mediated conditions (celiac disease, Crohn's disease, ulcerative colitis, type 1 diabetes, rheumatoid arthritis, sarcoidosis and psoriasisin several common immune - mediated conditions (celiac disease, Crohn's disease, ulcerative colitis, type 1 diabetes, rheumatoid arthritis, sarcoidosis and psoriasis).

Neurogeneticist Ivan Rodriguez of the University of Geneva in Switzerland and colleagues wondered whether there might be additional such receptors that respond to a disease «scent,» perhaps by detecting chemicals associated with bacteria and inflammation.

«We introduce a new definition of global health financing — one that includes additional public R&D spending for neglected diseases,» said lead author Marco Schäferhoff, PhD, of SEEK Development in Berlin, Germany.

Additional studies in other adult populations would further advance understanding of the diet's influence on heart disease risk.

Whilst established to examine possible safety issues with biologic therapies, it provides the opportunity to look at additional benefits beyond the direct effect on disease severity,» explains William Dixon, MD, MRC clinician scientist / senior clinical lecturer and honorary consultant rheumatologist; Arthritis Research UK Epidemiology Unit, The University of Manchester; and an investigator in the study.

The report suggests that patients may benefit from additional assurances from clinical staff regarding; success rates in halting disease progression with anti-VEGF therapy, how it can reduce the risk of becoming blind in the future, and the low likelihood of serious problems occurring following the injections.

Additional experiments using a combination of maraviroc and a drug that blocks the VEGF protein suggest that the treatment duo could be an effective way to prevent metastatic disease in human breast cancer patients, according to the researchers.

«We've seen hints before that PAK4 and PI3K pathway are linked, but finding evidence of their interaction is an important advance because it gives us additional avenues to explore in testing promising new inhibitor compounds that can tackle this disease,» says Dr Claire Wells, who led the study.

«This drug was not developed as an alternative to vaccination but rather as an additional weapon in our arsenal against the virus that may enable us to improve disease management and rapidly silence outbreaks,» he says.

These additional genetic elements, however, are already in use for screening and testing for diseases such as breast cancer, prostate cancer and autoimmune diseases, Richard Myers, president of HudsonAlpha Institute for Biotechnology in Ala., noted in the briefing.

The researchers plan to test additional potential targets in hopes that these particles could eventually be deployed to treat cancer, atherosclerosis, and other diseases.

But in many cases, unless there are additional spillover events, the disease eventually fades out.

The mean age of the K: B fusion population was 7.4 years old, compared to 15.2 years old in the non-K: B population; 73 percent of the K: B PAs were found in the cerebellum, whereas 78 percent of the non-K: B PAs were found elsewhere; and non-K: B PAs were much more likely associated with co-occurrence of the disease Type 1 Neurofibromatosis, which can lead to the formation of additional tumors.

Interestingly, IBS biologists uncovered additional miRNA end modifications after DROSHA processing, which are expected to be important for the regulation of miRNA biogenesis, whose dysregulation is often associated with diseases, in particular with cancer.

While this study indicates that the economic and disease burdens of dengue in India are hundreds of times greater than estimates based entirely on official reports, further studies are needed to garner additional detail.