Sentences with phrase «additional genes associated»

This research includes identifying additional genes associated with disease incidence in order to identify potential drug targets.

By 2008, when Moir stumbled on the parallels between amyloid - beta and LL - 37, Tanzi had discovered additional genes associated with Alzheimer's that were also related to innate immunity, the part of the human immune system that is shared with worms, flies, spiders and other primitive creatures.

Not exact matches

«Our stem cell - based studies indicate that low - calorie sweeteners promote additional fat accumulation within cells compared with cells not exposed to these substances, in a dose - dependent fashion — meaning that as the dose of sucralose is increased more cells showed increased fat droplet accumulation,» said Sabyasachi Sen, M.D., Associate Professor of Medicine at George Washington University in Washington, D.C. «This most likely occurs by increasing glucose entry into cells through increased activity of genes called glucose transporters.»

Many other genes have been linked to cleft lip or palate, and the researchers hope to understand if these additional genes are also associated with enhanced tooth decay.

SNPs in the human IL15 and IL15RA genes have been associated with muscle phenotypes (16), muscle responses to resistance training (17), metabolic syndrome (16), and obesity (18 — 20), providing additional rationale to support a role for these molecules in muscle.

GOMiner — To provide additional statistical stringency to the identification of potential targets, we then analyzed the data sets generated by the SAM - RS analysis of the microarray data for hypoxia - associated coregulation of multiple, functionally related genes.

Once the bacterial cell signaling protein cagA reaches the host cytosol, it is capable of altering subsequent generations of progenitor cells, leading to the development of cancer through changes in mitotic activity, apoptosis, cellular assembly, and signaling.26 Although it should be noted that while the presence of the cagA protein doubles the risk of gastric cancer, cagA - negative strands also increase the risk of distal gastric cancer.27 Additional H pylori virulence factors include babA2, which encodes bacterial adhesion with gastric epithelial cells, and vacuolating cytotoxin A, which is encoded by the gene vacA.28, 29 H pylori strains carrying some combination of the babA2, cagA, and vacA genes were associated with the highest risk of developing intestinal metaplasia.

However, the study also identified two additional genes that are associated with rheumatoid arthritis in Arabs but are not in Europeans and East Asians.

In the article describing the work in Molecular Therapy, co-authors Charis Himeda, Takako Jones and Peter Jones highlight the important implications for similar types of genetic diseases: «With increasing evidence that the repeat genome (comprising nearly half the human genome) plays important roles in gene regulation, additional diseases will likely be found associated with aberrant repetitive genomic sequences,» they write.

«It may have just a subtle influence,» suggests Dr. Cook, «but if we find two more autism - associated genes with the same prevalence — possibly additional hits along the same pathway — 16 percent cubed comes to four in a thousand, close to the frequency of autism.