Sentences with phrase «additional genes in»

There is evidence that the expression of hundreds of additional genes in adult rats changes in response to differences in maternal care [19].

To increase the number of women who will benefit from genetic testing for breast cancer, Rogan says doctors and government policy makers should include additional genes in testing and consider new approaches that can interpret complete gene sequences.

Testing for additional genes in the pathway and in a number of pathways is done through a number of commercial resources; the only other clinically relevant test is the homologous recombination defect assay, which is commercially available from Myriad Genetics.

Not exact matches

Immuno - oncology and gene therapy are two such areas where we plan to make additional hires in the coming months in an effort to ramp up our capabilities.

The first steps in this have already been accomplished with the transplanting of additional genes for growth hormone into sheep in Australia to produce larger animals and therefore more wool.

The researchers identified several reasons for this: The new gene constructs interfere with the plant's own gene for producing growth hormones, and the additional gene constructs were not, as intended, active solely in the kernels, but also in the leaves.

After finishing the survey, participants in the study can opt for an additional study and consider submitting DNA collected by a cheek swab to be tested for variants at the Apolipoprotein E (APOE) gene.

The researchers then found that these same genes carry an additional risk for a phenomenon called spreading depolarization, a slowly - progressing, temporary electrical blackout of a region in the brain.

Jaenisch says that the method that identified the single point mutation in SNCA's enhancer could be used to pinpoint additional pathogenic genes for sporadic PD and sift through the GWAS hits for other diseases, including Alzheimer's disease, cancer, diabetes, and multiple sclerosis.

Apparently, NPAS4 accounts for some addiction - related learning and memory processes in the brain, but not all of them, meaning that HDAC5 must be regulating additional genes that reduce relapse events.

In an additional group of endometriosis samples biopsied from 15 women at the University of British Columbia, the scientists looked specifically for mutations in the KRAS gene, whose expression signals proteins that spur cell growth and replicatioIn an additional group of endometriosis samples biopsied from 15 women at the University of British Columbia, the scientists looked specifically for mutations in the KRAS gene, whose expression signals proteins that spur cell growth and replicatioin the KRAS gene, whose expression signals proteins that spur cell growth and replication.

Note added in proof: Additional evidence for CA1 - CA3 differences is provided by a recent study measuring immediate early gene activation in two different novel rooms (36).

Our data demonstrate the feasibility of targeted gene disruption in multiple rat strains within 4 months time, paving the way to a humanized monoclonal antibody platform and additional human disease models.

An additional study, currently available at bioRxiv, led by the researchers from the CRG and Cold Spring Harbour Laboratory, highlights the fact that a substantial part of human and mice genes have maintained an essentially constant expression throughout evolution, in tissues and various organs.

In experiments on cell cultures, both of these inhibitors succeeded in breaking various forms of the TKI resistance: including forms caused by additional mutations of the gene Bcr - Abl as well as those caused by large quantities of the protein GabIn experiments on cell cultures, both of these inhibitors succeeded in breaking various forms of the TKI resistance: including forms caused by additional mutations of the gene Bcr - Abl as well as those caused by large quantities of the protein Gabin breaking various forms of the TKI resistance: including forms caused by additional mutations of the gene Bcr - Abl as well as those caused by large quantities of the protein Gab2.

«Our stem cell - based studies indicate that low - calorie sweeteners promote additional fat accumulation within cells compared with cells not exposed to these substances, in a dose - dependent fashion — meaning that as the dose of sucralose is increased more cells showed increased fat droplet accumulation,» said Sabyasachi Sen, M.D., Associate Professor of Medicine at George Washington University in Washington, D.C. «This most likely occurs by increasing glucose entry into cells through increased activity of genes called glucose transporters.»

Before the consortium came together, he had participated in sequencing the genomes of two vocal learners, a songbird and a parrot, but he knew he couldn't do all of the additional sequencing and analysis work that would be required to identify genes related to vocal learning — not by himself, at least — so he teamed up with Genome 10K, a project aiming to collect genomes for 10,000 vertebrate species.

Because environmental exposures have not had time to impact IBD progression in children, researchers have a clearer genetic picture of the disease allowing them to pick out additional genes overlooked in adult research, says senior study author Hakon Hakonarson, director of the Center for Applied Genomics at The Children's Hospital of Philadelphia.

Many of the additional 38 missing genes looked like they coded for proteins involved in controlling the activity of other genes.

Eight additional affected children in six unrelated families were found to also have disease - causing mutations in this gene.

The researchers scoured the already deciphered mouse genome, looking for genes that might encode additional receptor proteins in its olfactory system, the sensory cells that connect the nose to the brain.

Additional analysis revealed that ChABC gene therapy changed the way that inflammatory cells in the region respond following injury.

Additional support could come from the chimpanzee genome, which may allow researchers to clock when the genes for slow - twitch muscle fibers — crucial for running long distances and plentiful in people but not chimps — diverged in the common evolutionary history of humans and apes.

The cutting edge, however, is «gene doping,» in which additional copies of a naturally - occurring gene or modified copies may be inserted into an athlete's genome using a virus carrier.

This new gene expression data therefore provides additional evidence that the altered behavior of bacteria in space results from decreased gravity driving reduced extracellular transport of molecules.

The function of these genes were involved in molecular maintenance strategies, such as DNA repair, chromosomal maintenance, immune response and programmed cell death The authors argue that the «slower rate of change in these functions is consistent with increased constraint on somatic cell maintenance as would be required in these relatively long - lived and large - bodied mammals, illustrated by the additional large and long - lived species with slower rates in these genes (e.g. double - strand break repair gene XRCC4 is also highly constrained in elephant.»

While their preliminary experiments suggest the genes help control fluid levels in the cornea, Iyengar cautions that additional laboratory models will be needed to pinpoint their precise functions.

«If successful, these new treatments could also be applicable to a variety of additional cancers in which both genes are overexpressed.»

Although the gene / cell therapy strategy was highly successful in laboratory mice, the authors stressed that additional research and testing are needed before the therapy could be tested in humans.

Additional analysis showed that bile acid levels and genes involved in bile - acid regulation were changed in the offspring exposed to the maternal high - fat diet.

Next they tested an additional 27 genes that are known to be involved in various steps of ribosome biogenesis to verify whether SSUP was required for ESC maintenance.

Additional validation was undertaken in separate studies of children with meningococcal disease (n = 24) and inflammatory diseases (n = 48) and on published gene expression datasets.

«We generated over 600 engineered tobacco plant lines that harbour different combinations of these additional genes, and analysed them in terms of the amounts of artemisinic compounds they acquired.

But in a polyploid organism such as wheat, mutations in individual genes often have no apparent effect, because additional copies of the mutated gene compensate for the loss.

Scientist from the MPI for Heart and Lung Research in Bad Nauheim now found that additional genes compensate for a knocked out gene and either attenuate consequences or completely compensate deficits.

Additional genes included in the database could be the focus of future drug development efforts because they belong to classes of genes that are thought to make promising drug targets.

To further explore nuclear transport's role in Huntington's disease, Grima took lab - grown mouse neurons and used chemical switches to a) turn on both an additional healthy copy of the RanGAP1 gene and a mutant version of Huntingtin; b) just turn on the mutant Huntingtin; or c) just turn on a healthy version of Huntingtin.

But they provide additional gene markers in bipolar disorder that could potentially lead to the future development of diagnostics or treatments.»

This causes only mild thalassemia, but because other genes are deleted as well, there are additional problems — such as birth defects and mental retardation — that do not occur in most thalassemias.

Additional micro-patterning of the substrate changes the cytoskeleton in the cell and the shape of the nucleus, which cause the genes in the cell to change.

They think these additional genes paved the way for colorful and more structured and shapely flowers in later evolving angiosperms.

Although the cloned child will carry the same problem genes as the parent who donates the nucleus, he or she will in all likelihood enjoy the parent's state of health and will be free of the additional risks caused by mixing both parents» genes during sexual reproduction.

Additional examination of the two genes in anoxeria - prone families gave the researchers a handle on which DNA sequence variations conferred the most risk.

The two families had distinct facial dysmorphic features that led Karaca to identify the gene in three additional families with very similar features.

Additional experiments, including gene knockdown, surfaced prohibitin as a likely infection aide; prohibitin is a multi-functional protein found in human cells and in many other organisms.

In a second experiment, they used a different assay to look at an additional 6000 genes.

Pandolfi and colleagues sought to identify an additional tumor suppressing gene or pathway that may work in concert with PTEN to drive metastasis.

«We're confident that applying this same approach to a lot of new data will help us discover additional genomic variations and identify specific genes that play a role in schizophrenia and other psychiatric conditions.»

Overall, the new study suggests that genetic variations in the gene that codes for POU6F2 may affect the structure of the eye and increase a person's risk of glaucoma, but additional studies will be needed to describe the exact mechanism.

Thus we can conclude that mutations occurred in the CDR3s during the protein immunization phase resulting in neutralization ability, alongside additional mutations in the V gene which are required for breadth at least in the A14 / B9 lineage.