Sentences with phrase «additional ligands»
Based on this finding, it appears that myostatin can not be the sole target for FLRG in the transgenic mice and, therefore, that additional ligands must be capable of suppressing muscle growth in vivo.
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However, I carried out a similar set of experiments utilizing follistatin transgenic mice, which demonstrated that these additional ligands do play a major role in suppressing muscle growth.
Because I was unable to examine the effect of overexpressing FLRG in the complete absence of myostatin, it was difficult to ascertain the relative importance of these additional ligands compared to myostatin in regulating muscle mass.
These results suggest that the additional muscle mass induced by follistatin in Mstn null mice results from inhibition of additional ligands that act predominantly to regulate muscle fiber growth.
Expression and functional significance of an additional ligand for CTLA - 4.
Not exact matches
In bacteria, the ligand - PBP complex develops high affinity for transmembrane proteins such as Trg, and the chimeric Trg - HK protein allows activation of gene expression with one additional protein, a bacterial response regulator [5].
Additional work, however, revealed that in collaboration with TNFR1, TNFα can act upon TNFR2 through a ligand passing mechanism and trigger apoptosis [40].