Sentences with phrase «additional mutations»

The coming era of genome - based cancer treatment will vastly expand these opportunities; already, genome sequencing is identifying additional mutations unique to certain cancers.

In the process, it gained additional mutations, possibly via the DNA damage induced by chemotherapy.

They also plan to recruit more families with vibratory urticaria to further study the disorder and look for additional mutations in ADGRE2 and other genes.

However, scientists» ability to selectively modify DNA errors without introducing additional mutations into a patient's genome remains a challenge.

«When cancer comes back, it's genetically very similar to the original tumor but often with additional mutations that may give cancer cells new strategies to survive attack by whatever drugs are thrown at them.

In fact, most malignancies are thought to arise after a single initiating event, which may lead to genomic instability and thereby cause additional mutations.

In experiments on cell cultures, both of these inhibitors succeeded in breaking various forms of the TKI resistance: including forms caused by additional mutations of the gene Bcr - Abl as well as those caused by large quantities of the protein Gab2.

«In most cases we think the body's growth control mechanisms eventually stop the cells from proliferating further, but in occasional cases where additional mutations occur in the clump of cells, a tumour will eventually develop,» says Andrew Wilkie also of the University of Oxford, who supervised the work.

PE: Viruses push cells to the brink; additional mutations from genetic defects or the environment are needed for full - blown cancer.

«One of the major and immediate downstream effects of myc activation is a dramatic increase in the capacity of affected cells to make protein,» Ruggero said «This, in turn, leads to increased cell survival and proliferation, and to unstable genomes that foster additional mutations that turn these abnormal cells into tumor cells.»

Once the tumors are established in the mice, the researchers can introduce additional mutations at any time, allowing them to study the influence of each mutation on tumor initiation, progression, and metastasis.

In the absence of the «forgotten strands» DN2a cells fail to mature and ultimately after accumulating additional mutations become malignant T cells also named leukemias or lymphomas.

Geneticist Richard Sturm of the University of Queensland in Brisbane, Australia, an author of one of the papers says that someday scientists may find additional mutations that cause blue eyes but for now, the signs point to a single change.

GL B21 on the other hand bound to both immunogens (Fig. 7A, B) although to a lesser degree than B21 (Fig. 2A, B) which has additional mutations within the V gene.

That, in turn, generates free radicals — unstable molecules that can damage DNA, creating additional mutations that allow the tumor to become more invasive, infiltrating tissues and migrating to other parts of the body.

In some breeds, such as the French Bulldog, additional mutations not identified may affect eumelanin production.

So the small number of additional mutations that occur over the course of the rest of the lifespan, when the degenerative aging process is clearly taking root in our cells, can't plausibly be contributing much to age - related ill - health — except, again, for those (epi) mutations that lead to cancer.

«We're going to introduce additional mutations to sensitize the virus even more to the innate immune response and prevent the infection from spreading,» said Diamond, who also is a professor of molecular microbiology, and of pathology and immunology.

He infected ferrets with the hybrid virus, which then acquired two additional mutations.

This gives them the opportunity to build up the additional mutations they need to become fully malignant.

In the latest study, the international team revealed new insights into how this additional mutation leads to resistance, opening avenues for new treatments.

Indeed, all of the tumors from patients who carried this particular T - to - A mutation also had additional mutations that inactivate the APC gene.

A genetic mutation usually leads to crippled and misfolded proteins, but in rare instances an additional mutation can bring a protein back to life.

Kawaoka's group carried out a series of experiments that coaxed out additional mutations with that effect.

The additional mutations we detected could help in getting the best possible treatment results,» adds Antonarakis.

This suggests that every subclone persisting in the population picked up at least one additional mutation that gave it a competitive advantage.

«We looked for other mutations and found that an additional mutation was needed to activate hAgo1 slicing,» says Chris Faehnle, the first author of the paper.

This additional mutation is located in an area of the structure where it binds to RNA, known as the RNA binding groove.

The progression of the ancestral tumor cell to a full - blown cancer results from the sequential acquisition of additional mutations that confer a selective growth advantage to the original clone.

Similarly, there were dogs in the Australian Shepherd cohort, which were normal for the HSF4 mutation but developed various types of cataracts, indicating that additional mutations are likely to contribute to the development of cataracts in this breed (2).