Sentences with phrase «additional risk factors for»

While no other risk factors were observed for the development of ADHD - only, more deviant peer affiliations and lower SES did act as additional risk factors for ADHD + ODD, compared with controls.

Additional risk factors for poor father - child relationships identified during the pre-school and school - age years include: adverse family events; weak home organisation; a less supportive family ethos and low levels of positive parenting.

Low school ranking and smoking were additional risk factors for DSH in girls.

«develop a well - defined reference, or «baseline,» of good health as well as a rich data platform that may be used to better understand the transition from health to disease and identify additional risk factors for disease»

Sometimes, however, people overestimate their health or activity level, or detailed information can reveal additional risk factors for the applicant.

I realised that at almost 15 stones I was overweight and I also had a BMI of 29, both additional risk factors for diabetes on top of the high blood pressure and heart attack.

15 In fact, type 2 diabetes (T2D)-- a condition stemming from broken glucose metabolism and insulin signaling — has been identified as an additional risk factor for developing AD.16, 17 Moreover, the pathological changes that occur in AD in the brain physically resemble those seen in the pancreas and vasculature in T2D.9, 18 Type 2 diabetics who carry ApoE4 alleles are at the greatest risk for AD, with an even more severe risk reserved for those treated with exogenous insulin.19 This suggests that either T2D or related features of the metabolic syndrome bring about AD, or that they are separate consequences of the same underlying cause — and moreover, that insulin is a key factor.

Additionally, each 3.5 - ounce (100 - gram) decrease in weekly fish consumption was associated with a 19 % higher likelihood of having one additional risk factor for heart disease, such as high blood pressure, diabetes or obesity (22).

Sexual victimization among pregnant minority, adolescent mothers: An additional risk factor for adjustment difficulties.

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

Actual results, including with respect to our targets and prospects, could differ materially due to a number of factors, including the risk that we may not obtain sufficient orders to achieve our targeted revenues; price competition in key markets; the risk that we or our channel partners are not able to develop and expand customer bases and accurately anticipate demand from end customers, which can result in increased inventory and reduced orders as we experience wide fluctuations in supply and demand; the risk that our commercial Lighting Products results will continue to suffer if new issues arise regarding issues related to product quality for this business; the risk that we may experience production difficulties that preclude us from shipping sufficient quantities to meet customer orders or that result in higher production costs and lower margins; our ability to lower costs; the risk that our results will suffer if we are unable to balance fluctuations in customer demand and capacity, including bringing on additional capacity on a timely basis to meet customer demand; the risk that longer manufacturing lead times may cause customers to fulfill their orders with a competitor's products instead; the risk that the economic and political uncertainty caused by the proposed tariffs by the United States on Chinese goods, and any corresponding Chinese tariffs in response, may negatively impact demand for our products; product mix; risks associated with the ramp - up of production of our new products, and our entry into new business channels different from those in which we have historically operated; the risk that customers do not maintain their favorable perception of our brand and products, resulting in lower demand for our products; the risk that our products fail to perform or fail to meet customer requirements or expectations, resulting in significant additional costs, including costs associated with warranty returns or the potential recall of our products; ongoing uncertainty in global economic conditions, infrastructure development or customer demand that could negatively affect product demand, collectability of receivables and other related matters as consumers and businesses may defer purchases or payments, or default on payments; risks resulting from the concentration of our business among few customers, including the risk that customers may reduce or cancel orders or fail to honor purchase commitments; the risk that we are not able to enter into acceptable contractual arrangements with the significant customers of the acquired Infineon RF Power business or otherwise not fully realize anticipated benefits of the transaction; the risk that retail customers may alter promotional pricing, increase promotion of a competitor's products over our products or reduce their inventory levels, all of which could negatively affect product demand; the risk that our investments may experience periods of significant stock price volatility causing us to recognize fair value losses on our investment; the risk posed by managing an increasingly complex supply chain that has the ability to supply a sufficient quantity of raw materials, subsystems and finished products with the required specifications and quality; the risk we may be required to record a significant charge to earnings if our goodwill or amortizable assets become impaired; risks relating to confidential information theft or misuse, including through cyber-attacks or cyber intrusion; our ability to complete development and commercialization of products under development, such as our pipeline of Wolfspeed products, improved LED chips, LED components, and LED lighting products risks related to our multi-year warranty periods for LED lighting products; risks associated with acquisitions, divestitures, joint ventures or investments generally; the rapid development of new technology and competing products that may impair demand or render our products obsolete; the potential lack of customer acceptance for our products; risks associated with ongoing litigation; and other factors discussed in our filings with the Securities and Exchange Commission (SEC), including our report on Form 10 - K for the fiscal year ended June 25, 2017, and subsequent reports filed with the SEC.

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commfactors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commfactors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commfactors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange CommFactors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

The AAP recognizes that childbirth is dangerous, complications are common, any risk factors mean that the mother is not an appropriate candidate, and systems must be in place for the additional complications that will inevitably occur.

While it has yet to make the official list, some studies have identified VOCs and additional indoor air pollutants as a risk factor for SIDS.

What is most worrying is that this association was adjusted for maternal age, demographic factors, and underlying obstetric complications and therefore reflects the additional risk of the procedure itself.

Additional key risk factors for that allergy were found to be: not being breastfed, younger age at study enrolment, and higher Ara h2 IgE and higher peanut - specific IgE.

Other studies have reported similar results, even after controlling for additional risk factors, like child neglect, abuse, or having a mother with mental health problems (Lansford et al 2009; Coley et al 2014; Taylor et al 2010; MacKenzie et al 2015).

Additional evidence from studies which have looked at other aspects of social support such as the level of received support or sources of social support also provided evidence to support the hypothesis that the level of social support is an important factor in postpartum depression and that if social support is absent then it can be a potential risk factor for postpartum depression.

The agency has a good understanding of some risk factors for teen dating violence, such as family background, she said, and it is now studying the relationship between teen partners to see what additional risk factors can be found.

They said the key messages from the study were that stroke is a highly preventable disease globally, regardless of age and sex; that the relative importance of modifiable risk factors means there should be development of regional or ethnic - specific primary prevention programs, and that additional research on stroke risk factors is needed for countries and ethnic groups not included in INTERSTROKE.

A study by investigators at Brigham and Women's Hospital (BWH) published this week in PLOS ONE identifies four factors that may account for sex differences in statin therapy among patients with coronary artery disease (CAD), pointing to interventions and additional research that will be needed to help overcome this sex disparity and reduce cardiovascular risk for women.

Since smoking and obesity are risk factors for cardiovascular and metabolic diseases, the additional burden of craving more fats and sugars, while not fully tasting them, could be detrimental to health.»

«Right now, we recommend testing for the HLA - B * 5801 variant among those patients, and further research may help to identify additional factors that can improve risk management.

The number of missing teeth could be a useful additional indicator for general medical practitioners, when individual risk factors for chronic diseases are assessed, researcher John Liljestrand states.

Additional research is needed to determine how questions about peak alcohol consumption levels can be valuable in screening for alcohol misuse, as well as in assessing gender - specific risk factors and harms for drinking at extreme levels.

Professor Peymané Adab, Professor of Chronic Disease Epidemiology & Public Health, said: «This study contributes to existing evidence for sleep duration as a risk factor for obesity in childhood, and later bedtime as an additional risk factor — regardless of sleep duration.

Additional cancer risk factors were older age, receipt of hormone replacement therapy and smoking, but after controlling for these risk factors, fat ratio remained an independent risk factor.

For doctors, a practical approach might include screening all adults who have not been screened previously, and using their clinical judgment to consider a patient's risk factors, other health conditions and life events to determine if additional screening is warranted, the task force said.

Our study suggests that the immune response to an early infection, HSV - 2, may be the additional factor that increases the risk for severity of Zika virus - induced disease,» said Dr. Gil Mor, senior author of the American Journal of Reproductive Immunology study.

A recent analysis of the existing research on factors associated with an individual's risk for engaging in terrorist activity highlights how little we know about these factors and the need for additional research in this area.

These risks and uncertainties include, among others, those relating to our ability to obtain financing and to form collaborative relationships, uncertainty regarding potential future deterioration in the market for auction rate securities which could result in additional permanent impairment charges, our ability to develop and market diagnostic products, the level of third party reimbursement for our products, risks related to preclinical and clinical development of pharmaceutical products, including the identification of compounds and the completion of clinical trials, the effect of government regulation and the regulatory approval processes, market acceptance, our ability to obtain and protect intellectual property rights for our products, dependence on collaborative relationships, the effect of competitive products, industry trends and other risks identified in deCODE's filings with the Securities and Exchange Commission, including, without limitation, the risk factors identified in our most recent Annual Report on Form 10 - K and any updates to those risk factors filed from time to time in our Quarterly Reports on Form 10 - Q or Current Reports on Form 8 - K.

In 2009 and 2010, however, researchers confirmed additional gene variants of CR1, CLU and PICALM as possible risk factors for late - onset Alzheimer's.

Gerard Schellenberg, Ph.D., University of Pennsylvania School of Medicine in Philadelphia, leads the consortium, which aims to identify the additional risk factor genes for late - onset AD.

This genetic risk factor is independent of other risk factors, such as cholesterol, obesity and smoking, and therefore provides an additional method for identifying individuals who may derive benefit from earlier and more aggressive prevention efforts.

After adjusting for common factors that influence breast cancer risk, Henderson and colleagues found that women whose mammograms were classified as false - positive who were referred for additional imaging had a 39 percent increased chance of developing subsequent breast cancer during the 10 - year follow - up period, compared with women with a true - negative result.

For consumption, we used the midpoint of the reported number of cigarettes per day — for example, three cigarettes per day if the category was one to five cigarettes per day — which we then adjusted for carboxyhaemoglobin and cotinine because this allows for lower inhalation with increasing cigarette consumption as previously established.14 For studies that reported relative risks adjusted for age (or for additional factors), the model contained the logarithm of the relative risk (dependent variable) and consumption (independent variable) using only the midpoint of the cigarettes per day categoriFor consumption, we used the midpoint of the reported number of cigarettes per day — for example, three cigarettes per day if the category was one to five cigarettes per day — which we then adjusted for carboxyhaemoglobin and cotinine because this allows for lower inhalation with increasing cigarette consumption as previously established.14 For studies that reported relative risks adjusted for age (or for additional factors), the model contained the logarithm of the relative risk (dependent variable) and consumption (independent variable) using only the midpoint of the cigarettes per day categorifor example, three cigarettes per day if the category was one to five cigarettes per day — which we then adjusted for carboxyhaemoglobin and cotinine because this allows for lower inhalation with increasing cigarette consumption as previously established.14 For studies that reported relative risks adjusted for age (or for additional factors), the model contained the logarithm of the relative risk (dependent variable) and consumption (independent variable) using only the midpoint of the cigarettes per day categorifor carboxyhaemoglobin and cotinine because this allows for lower inhalation with increasing cigarette consumption as previously established.14 For studies that reported relative risks adjusted for age (or for additional factors), the model contained the logarithm of the relative risk (dependent variable) and consumption (independent variable) using only the midpoint of the cigarettes per day categorifor lower inhalation with increasing cigarette consumption as previously established.14 For studies that reported relative risks adjusted for age (or for additional factors), the model contained the logarithm of the relative risk (dependent variable) and consumption (independent variable) using only the midpoint of the cigarettes per day categoriFor studies that reported relative risks adjusted for age (or for additional factors), the model contained the logarithm of the relative risk (dependent variable) and consumption (independent variable) using only the midpoint of the cigarettes per day categorifor age (or for additional factors), the model contained the logarithm of the relative risk (dependent variable) and consumption (independent variable) using only the midpoint of the cigarettes per day categorifor additional factors), the model contained the logarithm of the relative risk (dependent variable) and consumption (independent variable) using only the midpoint of the cigarettes per day categories.

The researchers said finding a higher risk of diabetes even after adjusting for lifestyle factors and weight status suggests that additional factors, such as disruption of the circadian rhythm, may play a role.

Another study examining the effects the different lipids in terms of heart disease risk found that «triglyceride concentration was not independently related with CHD risk after controlling for HDL - C, non — HDL - C, and other standard risk factors, including null findings in women and under nonfasting conditions.21, 22 Hence, for population - wide assessment of vascular risk, triglyceride measurement provides no additional information about vascular risk given knowledge of HDL - C and total cholesterol levels, although there may be separate reasons to measure triglyceride concentration (eg, prevention of pancreatitis).»

Atrial fibrillation increases odds of stroke, but because these patients had few additional risk factors, they were considered at low risk for ischemic stroke (blocked blood flow to the brain).

The DCPS funding formula does differentiate public funding based on the number of students at each grade level and in different special needs categories, including special education, English language learners, and those «at risk» for academic failure.38 DCPS would not disclose how or if it factors in parental donations when determining school budgets or allocations.39 However, it did report not having a policy to equitably redistribute parent donations or to prohibit these additional dollars from being put toward staffing.40

Districts will get a per - pupil base amount and additional money for at - risk students and English language learners, among other factors.

The first tier involves early identification and assessment of at - risk students, the second tier includes referral to community resources for additional support services and the third tier enhances protective factors which increase resilience and provide defense against stressors.

The fixed income factors can be further adjusted to account for the yield curve and to add high yield credit risk as an additional factor.

There are additional risks related to commodity investments due to large institutional purchases or sales, changes in exchange rates, government regulation, world events, economic and political conditions in the countries where energy companies are located or do business, and risks for environmental damage claims, as well as natural and technological factors such as severe weather, unusual climate change, and development and depletions of alternative resources.

Fama and French later expanded their model to include fixed income, identifying term and default as two additional risk factors that explain returns for fixed income.

For corporate bonds, we consider environmental, social, and governance (ESG) factors to help identify additional risk.

These additional datasets will also help individuals understand how the changing climate affects public health in their area, risk factors that make a person more vulnerable to climate - related health effects, and how to plan for uncertain future conditions.

Applying for life insurance as a skydiver will trigger an additional mortality cost factor as would a scuba diver, drag racer and any other sports classified as high risk.

You might opt for additional coverage depending on your risk factors.

This can allow for additional growth potential (as well as additional risk, so it is important to also be aware of this factor).