Sentences with phrase «adenosine on immune cells»
The company showed how they first defined A2A as the receptor required for mediating the effect of adenosine on immune cells within the tumor microenvironment and reported the characterization of a novel immuno - oncology - dedicated adenosine receptor 2A antagonist that functions in the high adenosine concentration found in tumors.
http://www.iteostherapeutics.com/ Not exact matches
«Adenosine deaminase may help the immune system fight HIV on its own: Adenosine deaminase enhances anti-HIV-1 specific immune responses by reducing the action of cells that impede HIV - specific defenses.»
The adenosine A2A receptor is the main adenosine receptor expressed on immune cells, which promotes immune suppression, leading to tumor evasion.
The adenosine A2A receptor is the main adenosine receptor expressed on immune cells, which promote anti-tumor immune responses, leading to tumor regression when inhibited with an adenosine A2A antagonist.
Binding of adenosine to the A2A receptor on immune cells blocks the activation and effector functions of anti-tumor immune cells and promotes a regulatory, immune - suppressive phenotype.
receptor is the main adenosine receptor expressed on immune cells, which promotes immune suppression, leading to tumor evasion.
The adenosine A ₂ ₐ receptor is the main adenosine receptor expressed on immune cell subsets including T - cells, NK cells and dendritic cells and binding of adenosine to the A ₂ ₐ receptor on immune cells blocks the activation and effector functions of anti-tumor immune cells and promotes a regulatory, immune - suppressive phenotype.