Sentences with phrase «adenosine receptors»

A study by scientists from the Gladstone Institutes shows that decreasing the number of A2A adenosine receptors in a particular type of brain cells called astrocytes improved memory in healthy mice.

«Patience is required until A2A adenosine receptor antagonists are approved as new therapeutic agents for Alzheimer's disease.

«The results of the study are truly promising, since we were able to show for the first time that A2A adenosine receptor antagonists actually have very positive effects in an animal model simulating hallmark characteristics and progression of the disease.

Another way caffeine seems to improve performance during high - intensity exercise is by blocking adenosine receptors in the brain that promote relaxation.

The adenosine A2A receptor is the main adenosine receptor expressed on immune cell subsets including T - cells, NK cells and dendritic cells.

The adenosine A2A receptor is the main adenosine receptor expressed on immune cells, which promotes immune suppression, leading to tumor evasion.

This happens because of caffeine's affinity to bind with adenosine receptors in the muscles.

This compound had fewer adverse effects than caffeine since it only blocks only the A2A adenosine receptor subtype, and at the same time it is significantly more effective.

The team looked at 3 different genotypes involving adenosine receptor genes to see if any of them would indicate whether or not a person would have increased anxiety when consuming caffeine.

First and foremost, caffeine binds to adenosine receptors throughout the brain and nervous system.

This nutrient has the ability to inhibit adenosine receptors, stimulating your nervous system into overdrive.

While the mice showed no differences in learning, those that had fewer adenosine receptors performed better on tests of long - term memory.

Taking this one step further, the researchers performed the same experiments in a mouse model of Alzheimer's disease to see if these astrocytic adenosine receptors were also involved in memory loss associated with the disease.

The number of adenosine receptors dropped to normal levels, without apparent side effects, and asthma attacks were completely prevented for 12 hours.

Nyce's group created a single strand of DNA whose amino acids complement those in the messenger RNA that helps make adenosine receptors.

Cronstein and colleagues observed that mice lacking the A2A adenosine receptor did not move (walk) as easily or as well as mice with the receptor.

Linden's lab is now experimenting with adenosine receptor blockers capable of breaking through that shield to stimulate immune rejection of cancers.

Several genes were identified as upregulated after 1 h of hypoxia including adenosine receptor A2AR, and another group of genes was increased after 6 h of hypoxia including VEGF, adrenomedullin, and GLUT - 1.

The company showed how they first defined A2A as the receptor required for mediating the effect of adenosine on immune cells within the tumor microenvironment and reported the characterization of a novel immuno - oncology - dedicated adenosine receptor 2A antagonist that functions in the high adenosine concentration found in tumors.

Our novel data show that adenosine generated by MCs regulates tumor microenvironment by decreasing fibroblast responses to TGFβ acting through A2 adenosine receptors.

Caffeine, however, blocks your brain's adenosine receptor sites.

Adenosine is a neurochemical which many coffee - drinkers may be familiar with since: «Caffeine increases wakefulness [and often anxiety] by antagonizing adenosine receptors, and adenosine itself promotes sleepiness» and a feeling of calm.

It antagonises adenosine receptors, which may potentiate dopaminergic activity and exacerbate psychosis.

Caffeine is known to enhance energy levels and produce alertness because it blocks adenosine receptors in the brain, therefore preventing fatigue and sluggishness.

Researchers used a variety of methods to demonstrate that reducing adenosine or blocking the A1 adenosine receptor that is essential to the chemical messenger's function changed how adult mice responded to sound.

For this reason, Salvemini and colleagues teamed up with researchers from the National Institutes of Health, the University of Arizona and two institutes in Quebec, Canada, to investigate a new target for treating chronic pain: the A3 adenosine receptor or A3AR.

This explains why regular coffee drinkers build up a tolerance over time — because you have more adenosine receptors, it takes more caffeine to block a significant proportion of them and achieve the desired effect.

Researchers from the Gladstone Institutes have uncovered a new memory regulator in the brain involving adenosine receptors, which may offer a potential treatment to improve memory in Alzheimer's disease

The adenosine A2A receptor is the main adenosine receptor expressed on immune cells, which promote anti-tumor immune responses, leading to tumor regression when inhibited with an adenosine A2A antagonist.

receptor is the main adenosine receptor expressed on immune cells, which promotes immune suppression, leading to tumor evasion.

Immunological Invisibility Cloak Among them is Joel Linden, Ph.D., who recently reported that jamming signals transmitted by membrane proteins called adenosine receptors, which are expressed on T cells and on specialized cell - killing cells called NK cells, made both cell types more effective in halting lung metastasis of melanoma cells.

The researchers focused on astrocytes after their initial finding that patients with Alzheimer's disease have unusually high numbers of adenosine receptors in these cells.

When individuals consume caffeinated products, the caffeine binds and blocks adenosine receptors in the brain which prevents a person from feeling tired and fatigued.

Adenosine helps to sustain such cells by fitting into a protein called the A2A adenosine receptor on their surfaces, like a key into a lock.

Caffeine is known to stave off sleep in humans through pharmacological effects on the adenosine receptor.

Interestingly, caffeine apparently can prevent sleep in fruit flies despite the fact that it doesn't act through their adenosine receptor.

«Adenosine receptor can activate «off signals» for pain.»

In a study published in the April issue of the Journal of Neuroscience, Saint Louis University scientists led by professor of pharmacological and physiological sciences Daniela Salvemini, Ph.D., discovered that drugs targeting the A3 adenosine receptor can «turn off» pain signals in the spinal cord to provide relief from chronic pain.

It also suggests the possibility of designing better sleeping pills by finding compounds that mimic adenosine's effects, says McCarley, who points out that current drugs do not target the adenosine receptors.

Caffeine potentiated responses of mushroom body neurons involved in olfactory learning and memory by acting as an adenosine receptor antagonist.

Additionally, the current study provides support for other research suggesting that caffeine (whose main target is adenosine receptors) may improve normal memory function or even prevent Alzheimer's symptoms in older adults.

«Next, we will explore the therapeutic implications of our discovery by repurposing available drugs that block these adenosine receptors and are well tolerated in humans.»

It's uncertain whether other cell types, such as the immune cells that enter the lungs after an attack, have adenosine receptors — and scientists don't even know the source of the adenosine.