Sentences with phrase «adenoviral vectors»
Adenoviral vectors are tools that scientists use to deliver important genes into cells. They are like tiny vehicles that can carry the desired genes and help them enter the cells. These vectors are usually created from adenoviruses, which are harmless viruses that can infect cells temporarily. By using these vectors, scientists can introduce helpful genes into cells to treat diseases or study how cells work. Full definition
A featured paper in the February issue of the research journal Cancer Gene Therapy demonstrates that cancer cells in the liver are excellent targets for gene therapy using adenoviral vectors, based upon a fundamental new understanding of the differences between cancerous and normal liver cells.
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Svensson, Eric et al. «Long - term erythropoietin expression in rodents and non-human primates following intramuscular injection of a replication - defective adenoviral vector.»
The vaccines to be evaluated are based on an E1 - deleted simian adenoviral vector derived from a chimpanzee isolate.
«We also found that other cancer cells, including those from the breast, pancreas and prostate, are readily infected by adenoviral vectors indicating disorganized expression of the CAR receptor in these tumor cells.
Preparation and distribution of 19 reference antigens for several diseases including malaria, HIV and tuberculosis, and the establishment of five new cell banks to improve the growth of adenoviral vectors.
Both vectors are human serotype 5, replication - defective, first generation adenoviral vectors deleted in E1a and E3 viral encoding regions.
The InterPlay Adenoviral TAP System combines our unique tandem affinity purification (TAP) system with our exclusive adenoviral gene delivery system, the AdEasy Adenoviral Vector System, for enhanced gene delivery to a broader range of mam... Read more...
WA - based biotechnology company Imugene Ltd has won exclusive distribution rights for its porcine adenoviral vector delivery system, after success in a hearing administered by the US patent office.
The Ad5 / F35 adenoviral vectors were generated on an E1 / E3 deleted backbone.
A simian adenoviral vector termed adenovirus C68 (AdC68) was generated as a molecular clone to express the glycoprotein of rabies virus.
The gene - targeting approach developed by Suzuki and his colleagues relies on the use of so - called helper - dependent adenoviral vector to deliver large mutation - free DNA molecules into cells.
«At that time, I was treating patients with colon cancer that had spread to the liver using a very similar adenoviral vector administered in exactly the same way — direct infusion into the main artery feeding the liver,» said Reid, who is now an associate professor of clinical medicine in the UCSD School of Medicine.
2/13/2007 Study Shows Liver an Excellent Target For Cancer Gene Therapy Using Viral Vectors A featured paper in the February issue of the research journal Cancer Gene Therapy demonstrates that cancer cells in the liver are excellent targets for gene therapy using adenoviral vectors, based upon a fundamental new understanding of the differen... More...
«Long - term erythropoietin expression in rodents and non-human primates following intramuscular injection of a replication - defective adenoviral vector.»
This study will combine direct tumor cell killing (TK) and immune - mediated stimulatory (Flt3L) gene transfer approaches delivered by first generation adenoviral vectors.
In PNP's Phase I trial, an adenoviral vector is used to deliver E. coli PNP to head and neck tumors followed by intravenous administration of the prodrug fludarabine.
New molecular biology technologies — e.g., improved lenti - and adenoviral vectors, gene editing tools such as zinc - finger nucleases and the CRISPR / Cas9 platform — have opened doors to the development of novel gene - modified cellular therapies.
To investigate if AKT activation is sufficient to activate the mTOR pathway in ALK + ALCL cells, we infected the Karpas 299 and SU - DHL1 cell lines with an adenoviral vector, adeno - myrAkt, expressing constitutively active AKT (23).
«In the process of proving that liver toxicity is not an issue in gene therapy, we have also shown that cancer cells metastatic to the liver are a perfect target for gene therapy because the cancer cells, but not the normal liver cells, are infected by the adenoviral vector,» said Reid.
The researchers emphasized that while this study demonstrates that adenoviral vectors can be used to deliver targeted therapies and can be a useful tool for the treatment of cancer, further clinical trials are needed.
Under the mentorship of Drs. Richard L. Hurwitz and Catherine M. Bollard, he characterized the immune response against an adenoviral vector delivered intravitreally in retinoblastoma patients.
«Since the receptor is distributed randomly on the surface of tumor cells, the doorway is open for the adenoviral vectors circulating in the blood stream to infect and kill these cells,» said Reid, who was at Stanford University when this work was conducted.
The disorganized structure of the cancer cells exposes the receptors so that Onyx - 015, the adenoviral vectors used in this study, can readily enter tumor cells.
Two adenoviral vectors will be used, each to deliver one of the therapeutic genes.
Despite the marginal improvements in survival of patients suffering from malignant glioma treated with gene therapy vectors, the clinical trials conducted so far using viral vectors, in particular adenoviral vectors, have proven that the use of adenoviral vectors is a safe therapeutic approach, even in large, multicenter, phase 3 clinical trials.