Sentences with phrase «adenovirus vaccine trials»

«Many adenovirus vaccine trials are moving forward for HIV, malaria and TB with promising results and very few residual safety concerns,» he said.

Not exact matches

And a new analysis of the STEP trial, published last November in Proceedings of the National Academy of Sciences USA, provides a warning that the very vectors (adenoviruses, which are also employed in other vaccine development work) used to distribute the inactive HIV strains can actually make the immune system more vulnerable to infection by recruiting susceptible T cells to mucous membranes, where they are more likely to be infected during sexual activity.

So say scientists at Merck, who learned from trials in 2007 that their vaccine, based on a live, weakened adenovirus carrying genes for HIV proteins, was ineffective.

Initial results suggested that people who had already been exposed to the adenovirus, and so had antibodies to it, before they received the trial vaccine were more susceptible to HIV infection than people who did not receive the vaccine at all.

And a new analysis of the stopped STEP trial, published online Monday in Proceedings in the National Academy of Sciences, provides a warning that the very vectors (adenoviruses, which are also employed in other vaccine development) used to distribute the inactive HIV strains can actually prime the immune system to be infected by recruiting susceptible T cells to mucous membranes, where they are more likely to be infected during sexual activity.

The vaccine that has been tested in the United States was made from a cold - causing chimpanzee adenovirus that had been engineered to express proteins from two species of the Ebola virus, known as Zaire and Sudan (after their origins), and that was already available when the trial began in early September.

RV 172: A Phase I / II Clinical Trial to Evaluate the Safety and Immunogenicity of a Multiclade HIV - 1 DNA Plasmid Vaccine, VRC - HIVDNA016 -00-VP, Boosted by a Multiclade HIV - 1 Recombinant ADENOVIRUS - 5 Vector Vaccine, VRC - HIVADV014 -00-VP in HIV Uninfected Adu

Large - Scale Adenovirus and Poxvirus - Vectored Vaccine Manufacturing to Enable Clinical Trials.

2015 — Began a Phase 1b clinical trial of two experimental Ebola vaccines in Kampala, Uganda, using Chimpanzee Adenovirus type 3 vector (ChAd3) vaccines, co-developed by the VRC, National Institutes of Allergy and Infectious Diseases (NIAID) and GlaxoSmithKine.