Sentences with phrase «adenylyl cyclase»

Phen375 uses it to activate adenylyl cyclase and to raise cyclic AMP levels in your body cells.

Upon ligand binding, the Gs - coupled GPCR receptor activates adenylyl cyclase that in turn produces cAMP, governing important cellular responses.

Gi - coupled GPCR receptors, however, inhibit adenylyl cyclase and cAMP production.

Molecular cloning has demonstrated that dunce codes for the enzyme, cAMP phosphodiesterase; rutabaga codes for adenylyl cyclase; DCO codes for the catalytic subunit of protein kinase A, and CREB a transcription factor that is phosphorylated and activated by protein kinase A.

Scaffolding by A-kinase anchoring protein enhances functional coupling between adenylyl cyclase and TRPV1 channel.

N terminus of type 5 adenylyl cyclase scaffolds Gs heterotrimer.

The Groups II and III of glutamate receptor membranes are coupled to the intracellular G - protein subunit, these mediate the inhibition of adenylyl cyclase [40, 41].

The newly developed CB1 receptor selective antagonist SR141716A was found to reverse cannabinoid agonist (WIN55212 - 2 or CP55940)- induced adenylyl cyclase inhibition.

The characteristics of the inhibitory effect were dependent on the type of adenylyl cyclase and the nature of the activator of the enzyme.

The concentrations of Gi alpha required to inhibit adenylyl cyclase were substantially higher than those normally thought to be relevant physiologically.

Although type I adenylyl cyclase is inhibited directly by exogenous beta gamma, inhibition of adenylyl cyclase by Gi alpha has not been convincingly demonstrated in vitro.

G protein beta gamma subunits have been found to have regulatory effects on certain types of adenylyl cyclase.

This resulted in increased basal myocardial adenylyl cyclase activity, enhanced atrial contractility, and increased left ventricular function in vivo; these parameters at baseline in the transgenic animals were equal to those observed in control animals maximally stimulated with isoproterenol.

In the presence of Gs alpha, the alpha subunit of the G protein that activates adenylyl cyclase, one form of adenylyl cyclase was inhibited by beta gamma, some forms were activated by beta gamma, and some forms were not affected by beta gamma.

The alpha 2 and beta 2 adrenergic receptors, both of which are activated by epinephrine, but which can be differentiated by selective drugs, have opposite effects (inhibitory and stimulatory) on the adenylyl cyclase system.

His doctoral research focused on the regulation of the ERK / MAPK pathway by adenylyl cyclases during long - term memory formation and sensitization to drugs of abuse.

Concentration - dependent inhibition of adenylyl cyclases by purified Gi alpha subunits is described.

Not exact matches

Both CB1 and D2 receptors couple to Gi - o proteins and inhibit adenylyl - cyclase, whereas their costimulation results in Gs protein - dependent activation of adenylyl - cyclase (44, 45).