A number of methodological studies provide empirical evidence to support these precautions.152 153 Trials in which the allocation sequence had been inadequately or unclearly concealed yielded larger estimates of treatment effects than did trials in which authors reported
adequate allocation concealment.
Not exact matches
Three studies used
adequate methods for random sequence generation, but their methods for
allocation concealment were not clear (Paul 2012; Penfold 2014; Serwint 1996).
For the purpose of this review, we defined «high quality» as a trial having
adequate sequence generation,
allocation concealment and an attrition rate of less than 20 %.