«The new protein plays a key role in the formation of
adherens junctions of epithelial cells, and Listeria uses it for its own infectious process.»
One gene known to be important in maintaining apical - basal polarity and assisting in the formation
of adherens junctions in the retina is Crumbs (Crb), which encodes a transmembrane protein containing a long extracellular domain and a short C - terminal cytoplasmic tail.
Their analysis highlights defects
in adherens junctions and polarity in neural stem cells associated with haploinsufficiency of the cytoskeletal regulator CYFIP1.
Neogenin recruitment of the WAVE regulatory complex
maintains adherens junction stability and tension.
Using colorfully labeled antibodies to light up the new protein under their microscopes, they found that it was present where Listeria entered cells and also present
at adherens junctions between epithelial cells.
One avenue involves protein -
based adherens junctions, which allow sperm to attach to specialized cells in the testes.
Biomedical researchers at the Population Council identified a compound that interferes
with adherens junctions.
Functional perilipins (PLIN proteins encoded by the PLIN genes)(Lu et al., 2001) have been identified in very diverse organisms such as Drosophila (Teixeira et al., 2003), Dictyostelium (Du et al., 2013) and fungi (Wang & St Leger, 2007) and protein databases list clear orthologues in diverse, non-plant eukaryota, including the simplest metazoan
Trichoplax adherens, sponges, crustaceans, and choanoflagelates (UniProt proteins B3RRM2, I1GA14, G5DCP6, F2UJD9, respectively).
Müller cell apical processes appear to be lost in regions
lacking adherens junctions in these mice, as demonstrated by absent or reduced CD44 labeling and by electron microscopy.
Rehman and his colleagues study mechanisms that regulate cell - to - cell contacts
called adherens junctions.
Meanwhile, another group of French researchers identified the same protein, ARHGAP10, as a partner with two other molecules — Arf1 and Arf6 — involved in both actin dynamics deep within the cell and the turnover of
adherens junctions.
This figure shows a schematic representation of E-cadherin and interactome proteins at
an adherens junction.
As lungs begin to fill with fluid, the blood becomes under - oxygenated, and the cells lining the blood vessels react by tightening
the adherens junctions.
Central to
adherens junctions is a protein known as E-cadherin, or epithelial cadherin.
Structural components of
adherens junctions, cytoskeleton (F - actin) and homophilic bonds (E-cadherin) are quickly renewed at steady - state.
Akin to human RPE, the cells were highly polarized with basal nuclei, apical microvilli and
adherens junctions (Fig. 2C and 2D).
The other cellular junctions are called Gap junctions,
adherens junctions and desmosome junctions.