Indeed, when the mutant mice were chronically
administered cocaine, they actually spent more time in the side of a chamber where cocaine would be delivered.
To use reconsolidation to wipe out drug memories, Lu and his team first taught rats to self -
administer cocaine and heroin, so that they learnt to associate a particular environment with a drug high.
In animal studies this sharply reduces cravings and halts addicted animals» tendency to self -
administer cocaine and other habit - forming drugs.
In a 2014 paper, Lüscher's team demonstrated that mice taught to self -
administer cocaine over a longer time period also responded.
When the mice are given access to a machine that lets
them administer cocaine to themselves, the defeated mice take more of it.
Next, the rats were hooked up to a catheter and allowed to self -
administer cocaine.
Amphetamine - induced dopamine release: Markedly blunted in cocaine dependence and predictive of the choice to self -
administer cocaine
If the authors want to make conclusions regarding the role of NMDA receptors in vivo, then the authors need to
administer cocaine and the drug in vivo.
Not exact matches
The experimental therapy, which involves
administering a drug currently used in cancer therapy trials, treats
cocaine addiction by inhibiting memories responsible for cravings.
Using an animal model, the research team replicated
cocaine addiction by allowing rats to self -
administer as much
cocaine as they wanted (up to 40 doses) during a six - hour period.
However, a single self -
administered infusion of
cocaine at the end of abstinence, even after 60 days, fully reinstated tolerance to
cocaine's effects in the animals that had binged.
Hirsh and his colleagues Rozi Andretic and Sarah Chaney
administered aerosolized
cocaine to fruit flies and watched for signs of a fly high, such as compulsive grooming, proboscis extension, and flying in circles.
Michael Nader, PhD, investigates drug addiction in self -
administering nonhuman primates, focusing on
cocaine abuse.
My awareness at age 70 is at fault to where I had 4 different helpers in this time frame, one of these undesirables had to have either dropped or
administered the «
cocaine».