Adoptive immunotherapy refers to a medical treatment where a person's own immune cells are collected, modified, and then returned to the body to fight diseases like cancer or infections. These modified immune cells are trained to specifically recognize and eliminate the harmful factors, helping the body's natural defense system in fighting the disease.
Full definition
The article reviews current literature on the use
of adoptive immunotherapy for malignant gliomas as well as the the concept of antitumor activity mediated by CIK cells.
In adoptive immunotherapy, T cells are harvested, amplified or otherwise modified, and reinfused to boost the anticancer immune response.
Dr. Levine and the CVPF produced cells for the first infusions of purified activated CD4 + T cells
as adoptive immunotherapy, directed the first lentiviral transduced cell infusions, and the first infusions of zinc - finger nuclease - modified CD4 T cells.
While a postdoctoral fellow at the Naval Medical Research Institute in Bethesda, he developed a system for large - scale efficient culture of lymphocytes that has proved to be the foundation for over 35 early phase clinical trials
of adoptive immunotherapy.
A noted expert in his field, Dr. Collins has since the late 1980s helped to develop the treatment known
as adoptive immunotherapy, which involves manipulating a donor's immune system so that it attacks cancer cells.
He has led an international network in studies of
adoptive immunotherapy, and he applies the approach daily in his clinical practice.
A recognized leader in the field of
adoptive immunotherapy, Dr. Collins specializes in blood and marrow transplantation and hematologic malignancies such as leukemia, lymphoma, myeloma, Hodgkin's disease, and myelodysplasia.
Clinical - scale Rapid Autologous BK - virus Specific T Cell Line generation from Kidney Transplant Recipients with Active Viremia for
Adoptive Immunotherapy.
He maintains a research laboratory that studies various mechanisms of lymphocyte activation that relate to immune tolerance and
adoptive immunotherapy.
Inhibition of Akt signaling promotes the generation of superior tumor - reactive T cells for
adoptive immunotherapy.
Knowledge gained from mechanistic studies may contribute to the design of allogeneic vaccine - based or
adoptive immunotherapy for breast cancer.