Sentences with phrase «adult cell lines»

It performs this critical service in embryonic development, growing organisms and in a few specialized adult cell lines, including stem cells.

Not exact matches

The Weill Cornell researchers» process was more direct: Four transcription factors prompted adult mouse endothelial cells, which line the inside of blood vessels, to turn into HSCs.

In this study published in Cell Reports, Alexandra Van Keymeulen and colleagues generated a new transgenic line - allowing lineage tracing of ER + luminal cells to investigate luminal cell heterogeneity and identify the origin of ER + luminal cells and the mechanisms regulating their pubertal expansion and adult maintenaCell Reports, Alexandra Van Keymeulen and colleagues generated a new transgenic line - allowing lineage tracing of ER + luminal cells to investigate luminal cell heterogeneity and identify the origin of ER + luminal cells and the mechanisms regulating their pubertal expansion and adult maintenacell heterogeneity and identify the origin of ER + luminal cells and the mechanisms regulating their pubertal expansion and adult maintenance.

But just how close adult and reprogrammed stem cells can come to matching the capabilities of embryonic stem cells has become a contentious question in the debate over whether the federal government should continue funding research on embryonic lines.

As a result, every cell in the iPS cell line will contain the same mitochondrial DNA mutations as that initial adult cell.

In one promising approach, cellular reprogramming, stem cells can be generated by fusing adult skin cells with embryonic stem cells from existing cell lines.

During the last decade, some researchers have claimed that primordial follicles in adult mouse ovaries turn over and that females use adult germ - line stem cells to constantly resupply the follicle pool and sustain ovulation.

Researchers compared induced pluripotent stem cells lines reprogrammed from different adult cell types that have been previously differentiated from embryonic stem cells.

The only stem cell research he would permit, Bush said, was research using existing embryonic lines as well as so - called adult stem cells, which occur in anyone of any age.

L: We use adult stem cells, and we use the human embryonic cell lines that the government has already approved.

Recent studies have shown how to reprogram adult cells into non-embryonic stem cell lines called induced pluripotent stem cells — «pluripotent» meaning that they could give rise to almost any category of cell.

First, a hair follicle contains epithelial cells — a cell type that lines the body's vessels and cavities — as well as a specific kind of adult stem cell called dermal papillae.

During the next five years, KOMP2 will transform the knockout mouse embryonic stem (ES) cells into adult mice for 2,500 lines of well - characterized knockout mice strains, and IMPC will create about 2,500 additional knockout mouse strains.

Novel cell lines derived from adult human ventricular cardiomyocytes.

Sophia Millonigg (Eckmann, MPG)-- «The translational activator complex GLD - 4 / GLS - 1 regulates germline stem cell self - renewal and differentiation in the adult C. elegans germ line» (2013)

Robust regeneration of adult zebrafish lateral line hair cells reflects continued precursor pool maintenance.

Faculty Henri Jasper, PhD has already extended lifespan and healthspan in fruit flies by enhancing the regenerative capacity of the adult stem cells that line their mid-gut.

My post-doctoral work on the identification of genes required for normal germ line development and fertility led to the discovery that the germ line is exquisitely sensitive to mutations in components of the mitotic spindle that have the potential to lead to aneuploidy — this sensitivity may also extend to embryonic and adult stem cells.

Reprogramming adult cells to function like embryonic stem cells is one way researchers hope to create patient - specific cell lines to regenerate tissue or to study specific diseases in the laboratory.

Medical oncologist Alexander T. Pearson, MD, PhD cares for adults with head and neck cancers, especially squamous cell carcinoma, a common form of cancer that develops in the squamous cells that make up the middle and outer layer lining the mouth and throat.

Nakabayashi, Monk, and collaborators studied methylation patterns in adult and umbilical blood and placenta cells from healthy volunteers; brain tissue from a brain bank; and a cultured liver cell line.

Scientists from the Research Department of Cryo - Save Group NV together with the University of Cologne (DE) have developed a new scientifically validated method to collect adult mesenchymal stem cells («MSCs») from the lining of umbilical cord tissue.

Various cell types have been examined for use in RPE cell replacement including immortalized cell lines, such as the human RPE cell line, ARPE19 [2], sheets of adult RPE [3], foetal RPE [4], RPE derived from human embryonic stem cells (HESC - RPE)[5]--[10] and many non-RPE cells lines [11]--[15].

Here we investigate age - related mean and variance changes in gene expression measured by RNA - seq of fat, skin, whole blood and derived lymphoblastoid cell lines (LCLs) expression from 855 adult female twins.

We derived a fibroblast line from a skin biopsy from a healthy adult male (HUF1)(Figure 1A) and used immunocytochemistry to characterize the expression of cell surface markers commonly expressed on pluripotent stem cells (Figure 1B, C and D).

As FcRN receptors are also found in adult intestinal cells, coating the nanoparticles with Fc proteins (the part of the antibody that attaches to the FcRN receptor) and administering them orally in mice, caused the particles to grab hold of the FcRN in the intestinal lining and gained them and their payload entry into the bloodstream.

GLD -4-mediated translational activation regulates the size of the proliferative germ cell pool in the adult C. elegans germ line.

By developing a simple chemically defined culture system permitting efficient differentiation of numerous human iPS cell lines toward cells of a mature hepatic state, we now demonstrate the possibility of modeling groups of diseases of non-neuronal origin whose phenotypes are a consequence of complex protein dysregulation within adult cells.