Sentences with phrase «adult cell nucleus»

But the favored reprogramming technique, somatic cell nuclear transfer (SCNT), otherwise known as research cloning, is fraught with ethical pitfalls as well as technical difficulties because it entails creating a human embryo by inserting an adult cell nucleus into an ooctye.

«That meant you could reprogram an adult cell nucleus back to an embryonic stage.»

Expectations were low: it seemed almost impossible that an adult cell nucleus could be reprogrammed to give rise to a live animal.

An adult cell nucleus (upper right) is injected into a mouse egg that lacks genetic material.

Not exact matches

Then, the DNA would be removed from an oocyte (an egg cell) and this enucleated oocyte fused to the altered adult cell» creating a new cell that is neither an oocyte nor an adult cell but a hybrid exhibiting the properties programmed into it by the alterations made to the adult - cell nucleus.

Should the ANT - OAR proposal work, the alterations made to the adult nucleus will ensure that the cell produced by ANT - OAR enters immediately into a restricted, pluripotent state, without ever generating a totipotent embryo.

First, an adult cell would be removed from a patient and the DNA of that cell altered to control and direct the types of gene expression the nucleus is capable of supporting.

During cloning, the adult nucleus is converted to a totipotent state that will then proceed through a clear progression of developmental steps to yield pluripotent stem cells at a later time.

In this process, the nucleus of a donor adult cell is transferred to an egg whose nucleus, and thus its genetic material, has been removed.

Both involve a technique called nuclear transplantation — replacing the nucleus of a donor's egg with the DNA from an adult cell.

In the paper, published in the now - defunct online journal e-biomed, West, Lanza and their colleagues showed that they could pull a nucleus from a human egg cell, replace it with a whole adult ovarian cell and generate an embryo that divided into six cells.

In cloning procedures generally, nuclei are extracted from cultured cells that might have come originally from an embryo, a fetus or an adult organism.

In 1957, developmental biologists first discovered that they could insert the nucleus of adult frog cells into frog eggs and create dozens of genetically identical tadpoles.

Working with mouse, fly and human cells and tissue, Johns Hopkins researchers report new evidence that disruptions in the movement of cellular materials in and out of a cell's control center — the nucleus — appear to be a direct cause of brain cell death in Huntington's disease, an inherited adult neurodegenerative disorder.

When technicians move the nucleus of an adult cell into an egg, the clone will survive only if the egg successfully reprograms the newly installed genes to function as they would in an embryo.

The resulting embryos can grow up to be healthy adults, indicating that something in the egg's cytoplasm must prompt the nucleus to reverse the biochemical events that turned it into a specialized adult cell.

We're manipulating genes in the cell nucleus to produce specific proteins, changing the normal recipe for growth and maturation, and transforming adult cells into a new type of cell with the ability to morph into any other cell type,» said Cooke, senior author and chair of the Department of Cardiovascular Sciences.

Dolly was cloned using the technique of «somatic cell nuclear transfer,» when a nucleus from an adult cell is transferred into an unfertilized egg that has had its nucleus removed, and is then shocked with electricity to start cell growth.

Animal cloning uses a process known as somatic - cell nuclear transfer, where the nucleus from an adult (donor) cell is transferred into an egg (host) cell lacking a nucleus.

Something about the environment of the egg again turned on all of the genes in what had been a differentiated nucleus, reprogramming the adult DNA to its embryonic state, and the newly pluripotent cell was able to grow into a tadpole.

In 1996 researchers in Scotland used SCNT to transplant the nucleus of an adult sheep cell into an enucleated sheep egg, producing Dolly, the first cloned mammal.

SCNT is a technique wherein the nucleus from a somatic cell (an adult cell that is not a sperm or egg, i.e. not the gametes) is implanted into an enucleated egg cell which can then be implanted into, and develop in, a surrogate mother, and potentially become an adult organism.

SCNT is a technique wherein the nucleus from a somatic cell (an adult cell that is not a sperm or an egg) is implanted into an enucleated egg which can be implanted into, and develop, in a surrogate mother, and potentially become an adult organism.

In 1938, Hans Spemann showed that a nucleus from a fertilized salamander egg that had already undergone cell division several times could be implanted into a cell from a newly fertilized salamander egg that is enucleated (has had its nucleus removed) and create an entire adult salamander (Spemann, 1938).

Consequently, Spemann's work suggests that an embryonic nucleus remains totipotent, or is able to develop into any cell type of the adult body, even after several cell divisions.

For years it was unclear whether the nucleus from a fully differentiated, adult cell could be completely reprogrammed, as conflicting results were published by different groups (Briggs and King, 1957; Fishberg et al., 1958; Gurdon and Byrne, 2003).

In adult human heart PRDM16 is expressed in the nuclei of both cardiomyocytes and interstitial cells (Fig. 4a).

In this technique, the nucleus of an egg cell is removed and replaced with the nucleus of an adult cell, like a skin or blood cell.