Sentences with phrase «adult cells reprogrammed»

Like a Texan who keeps his drawl after moving to California, adult cells reprogrammed to resemble embryonic cells retain some signatures of the tissue from which they came.

Induced pluripotent stem cells (iPSCs)-- adult cells reprogrammed back to an embryonic stem cell - like state — may better model the genetic contributions to each patient's particular disease.

iPSCs are adult cells reprogrammed to become every type of tissue.

In mice, when adult cells are forced to fuse with stem cells, occasionally one of the adult cells reprograms itself, regressing back to an undifferentiated state.

Together with Kathrin Plath from UCLA, Vincent Pasque from KU Leuven led an international study into how adult cells reprogram to iPS cells.

Not exact matches

One can not help but be intrigued by the implications of the fact that these adult stem cells can be induced to «reprogram» themselves back to their beginning — all the way back to their embryonic beginning.

The ultimate goal of our laboratory is to generate ES - like cells directly from somatic cells by nuclear reprogramming... which converts adult cells back into embryonic state.

In 2005, before a Congressional hearing in the U.S., Prof. George Q. Daley of Harvard spoke forcefully and influentially about the necessity for embryonic stem - cell research to go ahead, and dismissed suggestions that one could work instead with «induced pluripotent stem cells» («iPS», i.e. stem cells reprogrammed from some cells of a living adult).

The new research took adult cells (skin cells), exposed them to four genes, and the genes appear to have reprogrammed the cells to a pluripotent state.

Scientists can either harvest the cells directly from the patient, harvest them from another patient, or they can genetically reprogram adult cells.

In the direct reprogramming, the researchers exposed the adult skin cells to a specific mix of signaling molecules the scientists» past research had found would convert healthy skin cells directly into a type of brain cell called medium spiny neurons, without intermediate steps along the way.

To make the HSCs, the Harvard group used human skin cells to create induced pluripotent stem cells (iPSCs), adult cells researchers genetically reprogram to an embryonic - stem - cell state, where they can grow into any kind of cell.

To solve these problems, Hingtgen's group wanted to see whether they could skip a step in the genetic reprogramming process, which first transforms adult skin cells into standard stem cells and then turns those into neural stem cells.

The MYC protein — which is one of the molecules used to reprogram iPSCs from adult cells — likely plays a role in dictating which sites in the genome are randomly methylated during the reprogramming process, the researchers hypothesized.

Further ahead, he is looking to an emerging technology known as induced pluripotent stem cells (iPSCs), in which adult cells are reprogrammed to be like embryonic stem cells so they can transform into any type of cell.

A group in Japan hopes to test a similar approach in humans using stem cells from reprogrammed adult cells within the next three years.

Cellular reprogramming turns an adult cell, such as a skin cell, into an induced pluripotent stem (iPS) cell.

Adult stem cells, reprogrammed or not, however, have not been shown to have the same level of flexibility in becoming any cell in the body.

• Scrutiny continued this week for Haruko Obokata, the Japanese stem - cell scientist whose apparent stunning advance — reprogramming adult stem cells by stressing them in acid — has proved difficult to reproduce, even by her own collaborators.

Others in that camp suggest that reprogrammed adult cells, (induced pluripotent, or iPSCs) can effectively replace the need for pluripotent embryonic stem cells.

But just how close adult and reprogrammed stem cells can come to matching the capabilities of embryonic stem cells has become a contentious question in the debate over whether the federal government should continue funding research on embryonic lines.

To reprogram cells, scientists typically add four genes (O, S, K, and MYC) to a dish containing adult cells.

Two types of stem cells were used to produce the mini-brains: embryonic cells and adult cells that had been reprogrammed to a starter state.

The scientists found that if they replaced MYC with LIN41 in the cocktail of genes involved in reprogramming — meaning if they used O, S, K and LIN41 — they could convert adult cells into iPSCs with the same efficiency.

But to convert adult cells into embryonic - like cells means genetic reprogramming, for example with a virus, and the reprogrammed cells do not yet match embryonic stem cells.

The Third International Congress on Responsible Stem Cell Research, scheduled for 25 - 28 April, was to focus on clinical applications of adult and reprogrammed stem cells.

The reprogrammed adult cells and organs prompted a regeneration in which damaged cells were replaced with new functional ones, he said.

Two new studies document one reason why: Adult cells maintain a memory of their original tissue even after being reprogrammed into iPS cells.

The research team took skin fibroblast tissue from adult mole - rats and reprogrammed the cells to revert to pluripotent stem cells.

These are cells taken from adult non-muscle tissues, such as skin or blood, and reprogrammed to revert to a primordial state.

In one promising approach, cellular reprogramming, stem cells can be generated by fusing adult skin cells with embryonic stem cells from existing cell lines.

The observations add weight to the theory that transforming an adult cell's DNA into an embryonic state is a gradual reprogramming process, Hochedlinger says.

Skin - producing cells called fibroblasts from the tip of an adult mouse's tail have been reprogrammed to make eggs, Japanese researchers report online October 17 in Nature.

«Maybe at the one - cell or two - cell stage,» Eggan and his colleagues reasoned, «there's still some of that stuff in there...» And if they picked the right moment of cell division, when these powerful reprogramming factors were still floating around in the periphery of the cell, they might be able to use drugs to temporarily freeze the cell in the middle of division, stick in the needle of a micromanipulator to suck out the embryonic DNA, squirt in DNA from an adult animal, and then kick - start the process of reprogramming — hours, perhaps even days after an egg had been fertilized.

Reprogramming of adult somatic cells into induced pluripotent stem cells (iPSCs) provides a powerful tool for in vitro disease modeling and drug screening.

The idea is that, by placing an adult cell from a diabetic, for example, into a human egg cell, the egg cell could turn back the clock of the adult DNA, or reprogram it, to its initial, pristine state.

The researchers speculate that the act of reprogramming adult cells to pluripotency may induce the expression of cell - surface molecules the immune system has not seen since the animal (or person) was an early embryo.

Alternatively, adult stem cells from the patient might be reprogrammed to provide genetically identical replacement tissue.

These stem cells, which are similar to highly sought - after embryonic stem cells but derived from adult cells and then reprogrammed, could be turned into the cell types needed for research, including neurons and intestinal and fat cells.

Three separate groups reported in June that they had reprogrammed adult mouse skin cells into a form nearly indistinguishable from ESCs.

The stem cell transcription factor SOX2, which is critical for stem cells, cell reprogramming, and brain development, also is activated in astrocytes in the adult brain.

Pluripotent stem cells include embryonic stem cells, which are derived from early embryos, and induced pluripotent stem cells, which are made by reprogramming cells taken from adult tissues such as skin.

KLF4 together with other reprogramming transcription factors is used in the lab to force the expression of genes in somatic cells (adult non-germline cells) in the development of iPSCs.

Researchers compared induced pluripotent stem cells lines reprogrammed from different adult cell types that have been previously differentiated from embryonic stem cells.

Researchers from the Centre for Genomic Regulation (CRG) in Barcelona have now described a novel mechanism by which adult cells can be reprogrammed into iPS cells successfully and in a very short period of time.

We have now discovered that this factor also acts as a catalyst when reprogramming adult cells into iPS,» explains Thomas Graf, senior group leader at the CRG and ICREA research professor.

Scientists use OCT4 protein to reprogram adult cells into embryonic - like cells, an indication that it is involved in early development (SN: 11/24/07, p. 323).

This experiment simulated the reprogramming of a patient's adult cells into induced pluripotent stem cells for further medical use.

In 2006, Yamanaka took Gurdon's work to the next level by reprogramming adult mouse skin cells into induced pluripotent stem cells.

Three teams of scientists reported earlier this year that they had directly reprogrammed adult mouse skin cells into embryonic cells, although the process involved viruses and cancer - causing genes.