Only a year after he produced the first iPS cells from adult mouse skin cells, Yamanaka generated iPS cells from
adult human skin cells, employing human versions of the same four genes that he had used in the mouse work.
Using Gladstone's unique expertise, the scientists then used induced pluripotent stem cells (iPSCs), generated from
adult human skin cells, to create a type of beating heart cell known as cardiomyocytes.
The brain organoid, engineered from
adult human skin cells, is the most complete human brain model yet developed, said Rene Anand, professor of biological chemistry and pharmacology at Ohio State.
Using viral gene insertion and regulatory proteins, researchers turned
adult human skin cells directly into adult human blood cells, without first returning them to a fully pluripotent state.
Not exact matches
To make the HSCs, the Harvard group used
human skin cells to create induced pluripotent stem
cells (iPSCs),
adult cells researchers genetically reprogram to an embryonic - stem -
cell state, where they can grow into any kind of
cell.
«Our results demonstrate for the first time that
human adult skin cells can be used to efficiently and rapidly generate functional pancreatic
cells that behave similar to
human beta
cells,» says Matthias Hebrok, PhD, director of the Diabetes Center at UCSF and a co-senior author on the study.
A California company reported today that it has, for the first time, cloned
human embryos using DNA from
adult skin cells.
Last month, Shinya Yamanaka at Kyoto University showed he could transform
adult skin cells into
cells akin to
human embryonic stem
cells.
In this new study, the scientists mimicked
human tissue formation by starting with stem
cells genetically reprogrammed from
adult skin tissue to form small chambers with beating
human heart
cells.
The
skin was changed directly into what appears to be functional
adult human blood
cells.
In this new study, the scientists mimicked
human tissue formation by starting with stem
cells genetically reprogrammed from
adult skin tissue to small chambers with beating
human heart
cells.
These
cells, first described in
humans in November 2007, are produced by inserting certain stem -
cell - associated genes into regular
adult cells (like
skin cells).
Dr. Yamanaka's discovery — how to transform ordinary
adult skin cells into stem
cells that, like embryonic stem
cells, can develop into any
cell in the
human body.
Recently, his lab used induced pluripotent stem (iPS)
cells —
adult cells made to act like embryonic stem
cells — made from
skin cells of patients carrying apoE4, or other mutations related to Alzheimer's, to study their effects on the development, survival, and degeneration of
human neurons.
Yamanaka's group used
human adult skin cells and induced them to become iPS
cells by having them produce the same protein factors that the mouse iPS
cells had.
However, while hESCs are created from
human embryos, iPS
cells are
cells that were originally from
adult tissues, such as
skin from an
adult body, but have been «reprogrammed» to a hESC - like state.
After completing his postdoctoral training at Gladstone, Dr. Yamanaka discovered an innovative technology that transforms ordinary
adult skin cells into stem
cells that, like embryonic stem
cells, can develop into virtually any
cell type in the
human body.
This award, named after the Chapter's co-founder Richard Essey and his wife Sheila, this year recognizes the far - reaching,
human - health impact of Dr. Yamanaka's Nobel Prize winning discovery of a way to transform
adult skin cells into
cells that act like embryonic stem
cells.
InvivoSciences makes engineered heart tissues from mouse embryonic stem
cells and stem
cells from differentiated
adult tissues in
humans, such as fat and
skin.
Shinya Yamanaka MD, PhD, a senior investigator at the Gladstone Institutes has won the 2012 Nobel Prize in Physiology or Medicine for his discovery of how to transform ordinary
adult skin cells into
cells that, like embryonic stem
cells, are capable of developing into any
cell in the
human body.
Other techniques can reprogram «
adult»
cells in the
human body taken from
skin, for example — but the
cells still carry baggage from their previous state.
In a paper being published online today in the scientific journal
Cell Stem
Cell, Sheng Ding, PhD, reveals efficient and robust methods for transforming
adult skin cells into neurons that are capable of transmitting brain signals, marking one of the first documented experiments for transforming an
adult human's
skin cells into functioning brain
cells.