Sentences with phrase «adult human tissue»

Induced pluripotent stem cells that were reprogrammed from normal adult human tissue.

So - called induced pluripotent stem (iPS) cells, which are derived from adult human tissue, have the added advantage of producing tissues and organs genetically matched to a recipient, avoiding the problem of immune system rejection.

Baran Y, Subramaniam M, Biton A, Tukiainen T, Tsang EK, Rivas MA, Pirinen M, Gutierrez - Arcelus M, Smith KS, Kukurba KR, Zhang R, Eng C, Torgerson DG, Urbanek C; GTEx Consortium, Li JB, Rodriguez - Santana JR, Burchard EG, Seibold MA, MacArthur DG, Montgomery SB, Zaitlen NA *, Lappalainen T * (2015) The landscape of genomic imprinting across diverse adult human tissues.

In contrast to germline variants, somatic variants are not propagated to the whole individual but to a subpopulation of cells in the body, with the final consequence that adult human tissues are a mosaic of genetically different cells.

Unlike most types of gene therapy, a longstanding approach that aims to alter only adult human tissues that die with the patient, the Crispr technique could be used to change human eggs, sperm and early embryos, and such alterations would be inherited by the patient's children.

Not exact matches

Whilst acknowledging that many questions remain unanswered in the debate between those who would advocate the use of stem cells taken from human embryos, and those experimenting on stem cells drawn from tissues of the adult human body, there is a lengthy discussion of the moral status of the human embryo as being a crucial matter in this regard.

«We wanted to investigate whether human adults had the ability to transform some white fat deposits into beige fat when they were exposed to cold,» said one of the study's authors, Philip A. Kern, MD, of the University of Kentucky School of Medicine in Lexington, KY. «Browning fat tissue would be an excellent defense against obesity.

Using a mouse model of HSV - 1 as well as autopsied samples of human adult and fetal tissues, investigators from Dartmouth College's Geisel School of Medicine found that antibodies against HSV - 1 produced by adult women or female mice could travel to the nervous systems of their yet unborn babies, preventing the development and spread of infection during birth.

The gradual shrinking of telomeres negatively affects the replicative capacity of human adult stem cells, the cells that restore damaged tissues and / or replenish aging organs in our bodies.

There are two types of fat in humans: white adipose tissue, which makes up nearly all the fat in adults, and brown adipose tissue, which is found in babies but disappears as they age.

Prins took human prostate stem cells from deceased young adult male organ donors and implanted the cells into mice, where they formed human prostate tissue.

Working with mouse, fly and human cells and tissue, Johns Hopkins researchers report new evidence that disruptions in the movement of cellular materials in and out of a cell's control center — the nucleus — appear to be a direct cause of brain cell death in Huntington's disease, an inherited adult neurodegenerative disorder.

Adult organisms ranging from fruit flies to humans harbor adult stem cells, some of which renew themselves through cell division while others differentiate into the specialized cells needed to replace worn - out or damaged organs and tisAdult organisms ranging from fruit flies to humans harbor adult stem cells, some of which renew themselves through cell division while others differentiate into the specialized cells needed to replace worn - out or damaged organs and tisadult stem cells, some of which renew themselves through cell division while others differentiate into the specialized cells needed to replace worn - out or damaged organs and tissues.

Replacement tissue that avoids rejection by a patient's immune system is a step closer to the clinic, as researchers have created human embryonic stem cells carrying the DNA of specific adults.

In this new study, the scientists mimicked human tissue formation by starting with stem cells genetically reprogrammed from adult skin tissue to form small chambers with beating human heart cells.

The so - called WNT proteins carry messages into cells and regulate embryonic and adult tissue in mammals, including humans.

Single - cell RNA - Seq analysis also helped researchers benchmark the engineered 3D liver tissues generated from stem cells against naturally occurring human fetal and adult liver cells.

In this new study, the scientists mimicked human tissue formation by starting with stem cells genetically reprogrammed from adult skin tissue to small chambers with beating human heart cells.

Sphingosine -1-phosphate mediates proliferation maintaining the multipotency of human adult bone marrow and adipose tissue - derived stem cells (Retraction of vol 2, pg 199, 2010).

Comparison of human adult stem cells from adipose tissue and bone marrow in the treatment of experimental autoimmune encephalomyelitis.

Researchers from Australia generated primitive human kidney tissues from adult stem cells, a recent study says.

Functional expression of HGF and HGF receptor / c - met in adult human mesenchymal stem cells suggests a role in cell mobilization, tissue repair, and wound healing.

Sphingosine -1-phosphate mediates proliferation maintaining the multipotency of human adult bone marrow and adipose tissue - derived stem cells.

Sphingosine -1-Phosphate Mediates Proliferation Maintaining the Multipotency of Human Adult Bone Marrow and Adipose Tissue - derived Stem Cells (Retracted article.

2007 also saw one of the most game - changing developments in the stem cell field; researchers learned how to create cells like embryonic stem cells, but instead of coming from an embryo these cells are created from adult cells, potentially cells from any tissue in the human body.

Unlike embryonic stem cells, which are developmental blank slates that can generate virtually all types of cells found in adult humans, adult stem cells are thought to possess limited potential to transform into cells found in their tissues of origin.

iPSCs are cells that were originally from adult tissues, but have been forced to produce proteins that are thought to be essential for the pluripotency of human embryonic stem cells.

First, while adult stem cells (stem cells isolated from a variety of adult tissues) are limited in their lifespan, hESCs can be grown and expanded indefinitely, potentially creating an infinite number of hESCs from a single human embryo.

However, while hESCs are created from human embryos, iPS cells are cells that were originally from adult tissues, such as skin from an adult body, but have been «reprogrammed» to a hESC - like state.

Regenerative medicine aims to use adult or embryonic stem cells to replace or regenerate human cells, tissue, or organs and restore normal function.

InvivoSciences makes engineered heart tissues from mouse embryonic stem cells and stem cells from differentiated adult tissues in humans, such as fat and skin.

Eight HARs showed differences in their enhancer activity when the human mutations were present.4 These differences modify how genes were expressed in the developing limb (HAR2, 2xHAR114), eye (HAR25), and central nervous system (2xHAR142, 2xHAR238, 2xHAR164, 2xHAR170, ANC516 / HARE5).4, 10 Because relatively few time points have been examined, it is likely that an even higher percentage of the tested HARs are active enhancers at some point during embryonic development or in adult tissues, possibly with human - chimp differences.

The adult human heart is only half muscle; the other half is made of support cells called fibroblasts that help repair wounds and form scars around damaged tissue.

They have a high chance of being transmitted to offspring as de novo germline mutations and, in principle, can provide insights into early human embryonic cell lineages and their contributions to adult tissues.

Prof. Dr. Ivan Martin's research group at the Department of Biomedicine has now been able to demonstrate that by forcing certain molecular events occurring during the embryonic development of articular cartilage it is possible to generate stable cartilage tissue from adult human mesenchymal stem cells.

The relatively new rediscovery of active brown adipose tissue in adult humans has generated interest in this tissue as a novel and viable target for stimulating energy expenditure and controlling body weight by promoting energy dissipation.

For human tissue regeneration to become a viable therapy for conditions like neurodegeneration or diabetes, clinicians will likely need to artificially manipulate factors that return adult brain or pancreatic cells to a cellular «Tir Nan Og» to restore adult cell types.

«While an adult human brain typically weighs only about 2 % of the body weight, a resting brain consumes more than 20 % of all the oxygen, thus indicating a 10-fold greater energy requirement than other tissues.