Sentences with phrase «adult mice and humans»

Ultimately, Godwin would like to understand why macrophages produced by adult mice and humans don't suppress scarring in the same way as in axolotls and then identify molecules and pathways that could be exploited for human therapies.

Adult mice and humans can regenerate digit tips, although humans lose this ability with age, suggesting that regenerative abilities could be reawakened in mammals.

In their study «D - Serine and Serine Racemase are Localized to Neurons in the Adult Mouse and Human Forebrain,» the lab utilized SR deficient (SR - / --RRB- mice, which have < 15 % of normal D - serine levels, to validate and optimize a D - serine immunohistochemical method.

Not exact matches

The team found neonatal mice with the mutations had normal - appearing skin, and the dry itchy skin of dermatitis did not develop until the mice were a few months old, the equivalent of a young adult in human years.

The investigators report that trapping virus - loaded stem cells in a gel and applying them to tumors significantly improved survival in mice with glioblastoma multiforme, the most common brain tumor in human adults and also the most difficult to treat.

Using a mouse model of HSV - 1 as well as autopsied samples of human adult and fetal tissues, investigators from Dartmouth College's Geisel School of Medicine found that antibodies against HSV - 1 produced by adult women or female mice could travel to the nervous systems of their yet unborn babies, preventing the development and spread of infection during birth.

The results obtained by Afsaneh Gaillard's team and that Pierre Vanderhaeghen at the Institute of Interdisciplinary Research in Human and Molecular Biology show, for the first time, using mice, that pluripotent stem cells differentiated into cortical neurons make it possible to reestablish damaged adult cortical circuits, both neuroanatomically and functionally.

To test the hypothesis, Frankland and his team first compared the stability of memories in adult mice versus 17 - day - old mice, which are equivalent to human babies less than a year old.

Because neurogenesis surges in newborn mice and humans and then tapers to a slow trickle by adulthood, Frankland and colleagues wondered if that explosion of new neurons could help explain the widespread phenomenon of infantile amnesia — the inability of adults to remember events that occurred before they were 2 to 4 years old.

Prins took human prostate stem cells from deceased young adult male organ donors and implanted the cells into mice, where they formed human prostate tissue.

Working with mouse, fly and human cells and tissue, Johns Hopkins researchers report new evidence that disruptions in the movement of cellular materials in and out of a cell's control center — the nucleus — appear to be a direct cause of brain cell death in Huntington's disease, an inherited adult neurodegenerative disorder.

Because of the difficulties involved in harvesting and culturing adult human neurons, most research on DRG neurons has been done in mice.

This presumably means that, at the adult stage, human astrocytes, in contrast to mouse astrocytes, are better at detecting neuroactivity and adjusting their functions in response.

A treatment group of mice were given an intake of folic acid 20 times greater than the RDA for humans: while the folic acid dosage consumed by most adults is lower and taken over a longer period of time, a higher dose was used in this study to account for the fact that mice are more efficient in metabolizing folic acid than humans.

Xiaowei «George» Xu, MD, PhD, associate professor of Pathology and Laboratory Medicine and Dermatology at the Perelman School of Medicine, University of Pennsylvania, and colleagues published in Nature Communications a method for converting adult cells into epithelial stem cells (EpSCs), the first time anyone has achieved this in either humans or mice.

A total of 22 mouse mutant lines can be characterised through a broad based primary phenotyping pipeline in all the major adult organ systems and most areas of major human disease.

Gene expression patterns in normal adult or the developing retina have been reported for mouse [18 — 23], aged and normal adult human [24 — 26], canine [27], and rabbit [28].

And they still have to discover and test drugs that can do this for natural - born adult humans; the mice used in this study were genetically engineerAnd they still have to discover and test drugs that can do this for natural - born adult humans; the mice used in this study were genetically engineerand test drugs that can do this for natural - born adult humans; the mice used in this study were genetically engineered.

Paracrine signalling loops in adult human and mouse pancreatic islets: netrins modulate beta cell apoptosis signalling via dependence receptors.

Having shown that it's possible to directly reprogram mouse fibroblasts (in a dish and in adult hearts) and also human heart fibroblasts in a dish, Dr. Srivastava's group is testing the recipe in pigs, whose heart size and physiology is closer to our own.

Yamanaka's group used human adult dermal fibroblasts and induced them to become iPSCs, appearing and functioning like hESCs, by having them express the same proteins as he used with mouse cells: Oct - 4, Sox2, Klf4, and c - Myc (Takahashi et al., 2007).

I'm not saying we must test this humans but testing faster ECM turnover rates in older adult mice, cat's, dogs, pigs, naked mole rats, apes and other close - related mammals to human to see how bad it gets, and if it's possible to revert to pre-adolescence or, at the latest, very - early adulthood levels.

Yamanaka's group used human adult skin cells and induced them to become iPS cells by having them produce the same protein factors that the mouse iPS cells had.

GIND investigator Li Gan, PhD, and her collaborators studied the development of neurons born in the hippocampus of adult mice genetically engineered to produce high levels of human Aβ in the brain.

These mice developed hallmark signs of PD in their brains and behavior: loss of dopaminergic neurons in the SNc, impaired generation of new neurons in one of the few regions capable of producing them in adult organisms, and impaired muscle coordination similar to human victims of Parkinson's (as evidenced by difficulty in rearing up on their hind legs)(Figure 2).

Mouse mutant lines can be tested through a broad based primary phenotyping pipeline in all the major adult organ systems and most areas of major human disease.

Starting with transplants of human oligodendrocytes in the late 1980s [40], and more recently with populations of human oligodendrocyte progenitor cells isolated from the developing or adult CNS, or from human embryonic stem cells, it has been possible to generate extensive myelination upon transplantation into spinal cord injury or into congenital mouse models of hypomyelination [41]--[48].

TPH2 (55 KDa) was detected using a goat anti − mouse IgG horseradish peroxidase - conjugated secondary antibody (1:10 000; Bio-RAD, Hercules, California) followed by Chemiluminescence ECL (PerkinElmer, Waltham, Massachusetts) and quantified from densitometry bands (MCID Elite 6; Imaging Research Inc, Ontario, California) standardized to human adult raphé obscurus run on the same gel.

Test each mutant mouse line (4,000 mouse lines in the first 5 years, and ultimately up to 20,000) through a broad based primary phenotyping pipeline in all the major adult organ systems and most areas of major human diseases.Through this activity and employing data annotation tools, systematically aim to discover and ascribe biological function to each gene, driving new ideas and underpinning future research into biological systems.

InvivoSciences makes engineered heart tissues from mouse embryonic stem cells and stem cells from differentiated adult tissues in humans, such as fat and skin.

Together with previous findings, a total of seven out of eight bilaterian species examined (human, mouse, cattle, chicken, fish medaka, sea urchin and fruit fly) representing three different phyla express Boule in the adult testis [35], [53], [60].

Pluripotent stem cells can be generated from adult mouse - tail tip fibroblasts and adult human fibroblasts by the retrovirus - mediated transfection of four transcription factors, Oct3 / 4, Sox2, c - Myc, and Klf4.

Three recent experimental studies focused on low consumption / exposure.949596 In one study, 29 smokers each consumed a single cigarette, immediately after which they had a significant decrease in blood vessel output power and significant increase in blood vessel ageing level and remaining blood volume 25 minutes later, as markers of atherosclerosis.94 In another study, human coronary artery endothelial cells were exposed to the smoke equivalent to one cigarette, which led to activation of oxidant stress sensing transcription factor NFR2 and up - regulation of cytochrome p450, considered to have a role in the development of heart disease.95 These effects were not seen when heart cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain cells.96

The delicate balance between the human microbiome and the development of psychopathologies is particularly interesting given the ease with which the microbiome can be altered by external factors, such as diet, 23 exposure to antimicrobials24, 25 or disrupted sleep patterns.26 For example, a link between antibiotic exposure and altered brain function is well evidenced by the psychiatric side - effects of antibiotics, which range from anxiety and panic to major depression, psychosis and delirium.1 A recent large population study reported that treatment with a single antibiotic course was associated with an increased risk for depression and anxiety, rising with multiple exposures.27 Bercik et al. 28 showed that oral administration of non-absorbable antimicrobials transiently altered the composition of the gut microbiota in adult mice and increased exploratory behaviour and hippocampal expression of brain - derived neurotrophic factor (BDNF), while intraperitoneal administration had no effect on behaviour.