In this new study, the scientists mimicked human tissue formation by starting with stem cells genetically reprogrammed from
adult skin tissue to small chambers with beating human heart cells.
In this new study, the scientists mimicked human tissue formation by starting with stem cells genetically reprogrammed from
adult skin tissue to form small chambers with beating human heart cells.
Not exact matches
According to Science Daily, Dr. Nagy, senior investigator at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital, there is a «new method of generating stem cells that does not require embryos as starting points and could be used to generate cells from many
adult tissues such as a patient's own
skin cells.»
Whether building organs or maintaining healthy
adult tissues, cells use biochemical and mechanical cues from their environment to make important decisions, such as becoming a neuron, a
skin cell or a heart cell.
The research team took
skin fibroblast
tissue from
adult mole - rats and reprogrammed the cells to revert to pluripotent stem cells.
These are cells taken from
adult non-muscle
tissues, such as
skin or blood, and reprogrammed to revert to a primordial state.
Organlike
tissue bits can be generated from pluripotent stem cells that are either plucked from embryos or created by taking a person's
adult skin or blood cells and chemically inducing them to revert to an embryonic - like state.
Pluripotent stem cells include embryonic stem cells, which are derived from early embryos, and induced pluripotent stem cells, which are made by reprogramming cells taken from
adult tissues such as
skin.
Converting
adult skin cells into pluripotent cells — immature stem cells that can be programmed to become any
tissue in the body — is a rapidly developing area of science that earned the researcher who discovered the technique, Shinya Yamanaka, a Nobel Prize in 2012.
In
adult organisms, stem cells and progenitor cells act as a repair system for the body, replenishing specialized cells, but also maintain the normal turnover of regenerative organs, such as blood,
skin, or intestinal
tissues.
The researchers were able to «reprogram»
adult skin cells to become cells of a different
tissue type.
However, while hESCs are created from human embryos, iPS cells are cells that were originally from
adult tissues, such as
skin from an
adult body, but have been «reprogrammed» to a hESC - like state.
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Adult mammals can restore other types of
tissue, including bone, liver and
skin tissue, but by the strictest definition — the faithful replacement of damaged or resected body parts — they can only regenerate their fingertips.
InvivoSciences makes engineered heart
tissues from mouse embryonic stem cells and stem cells from differentiated
adult tissues in humans, such as fat and
skin.
Last year Thomson shook the field again when his lab and a Japanese team showed a way of genetically reprogramming
adult skin cells to act like stem cells, including the ability to form any of the body's
tissues.
The
skin and other stratified epithelia as model
tissues display a high turnover rate, and contain well - defined populations of
adult stem cells (SCs).
In randomized experimental and data analysis protocols, MSI - 1346 has been shown to regenerate heart, connective, nerve,
skin, bone and vascular
tissues in
adult zebrafish.
Adult stem cells serve as a reservoir of cells for repair of damaged
tissue throughout the life of an individual, but the maintenance and regeneration of
tissues, such as
skin, liver, blood and muscle, dramatically decrease with age.
Unfortunately, the number of
adult stem cells present in local areas of the body vary greatly in number and most researchers agree that there are simply not enough stem cells «at the ready» within brain
tissue to heal itself in the same way the
skin does after a cut.
Male and female
adult worms find each other in a dog's episcleral
tissues, mate and produce microfilaria that leave the orbit and travel through the
skin primarily of the head and back.