Sentences with phrase «adult stem cell function»

What intrinsic (cell autonomous) mechanisms regulate adult stem cell function, and how are they deregulated during ageing and cancer?

Not exact matches

Of particular interest to stem cell and regenerative medicine researchers, the finding may lead to laboratory methods to create heart cells that function more like those found in adult hearts.

By specifically targeting the pause signal that prevents restarting DNA repeat synthesis, telomerase enzymatic function can be supercharged to better stave off telomere length reduction, with the potential to rejuvenate aging human adult stem cells.

One theory has been that calorie restriction slows age - related degeneration and enables more efficient tissue function by influencing the integrity and activity of adult stem cells, the precursor cells that dwell within specific tissues and give rise to the diversity of cell types that compose that tissue.

Stowers researchers discovered that megakaryocytes directly regulate the function of murine hematopoietic stem cells — adult stem cells that form blood and immune cells and that constantly renew the body's blood supply.

A new study in rats shows that lacing a penis graft with adult stem cells yields better healing and sexual function than using the graft alone.

Adding adult stem cells (inset) to penis grafts improves healing and sexual function in rats.

Studies in the last two decades revealed that telomeres and telomerase have dual functions in suppressing and facilitating tumorigenesis: In the adult human, the activity of telomerase is mostly restricted to the stem cells and is absent from the vast majority of human cells.

For the first time in a large regulated clinical trial, adult BM - derived stem cells allowed chronic paralyzed SCI patients to regain sensory functions and some abilities to walk.

A normally functioning adult human brain has the ability to partially replenish or repair itself through neurogenesis, the proliferation and development of adult neural progenitor / stem cells (aNPCs) into new nerve cells.

Patients tell us adult stem cell therapy has reduced symptoms and restored function and quality of life.

Reprogramming adult cells to function like embryonic stem cells is one way researchers hope to create patient - specific cell lines to regenerate tissue or to study specific diseases in the laboratory.

The other one, the finding by the Clevers group in Utrecht that adult Lgr5 + stem cells from the intestine, grown 3D in the presence of basement membrane matrix and a defined set of niche factors, can develop into ever - expanding, genome - stable 3D organoids that resemble the structure and function of the original intestinal epithelium (13 - 16).

Dr. Fallon's research program is primarily in four areas, including adult stem cells, chemical neuroanatomy and circuitry, higher brain functions, and brain imaging.

The approach involves reprogramming skin cells into pluripotent stem cells, or cells that can give rise to any other fetal or adult cell type, and then inducing them to differentiate, or transform, into cells that perform a particular function — in this case, secreting insulin.

They made adult fibroblastic mouse cells become essentially mouse embryonic stem cells, in appearance and function, by forcing the fibroblasts to express four key embryonic stem cell factors: Oct - 4, Sox2, Klf4, and c - Myc.

By stimulating the growth of new blood vessels, promoting anti-inflammatory effects, recruiting cells toward tissue regeneration and inhibiting further cell death, adult stem cells can restore some function to damaged or diseased heart muscle.

These cells, called induced pluripotent stem cells (iPSCs), are created by forcing adult cells to produce proteins specific to embryonic stem cell functions, causing the adult cells to look and act like ESCs.

They made adult mouse cells become essentially mouse embryonic stem cells, in appearance and function, by forcing the adult cells to produce four key protein factors.

As a function of age, the capacity for adult stem cells to self - renew declines.

This treatment delivers an infusion of adult stem cells safely to the heart to address pumping function for symptomatic relief and a better quality of life.

Although your adult stem cells have the capacity to repair or replace damaged tissue, the powerful cells which reside in your body fat (or adipose tissue) have a few other important functions which make them uniquely qualified for the job of treating chronic disease:

Adult stem cells are commonly referred to as «repair cells» for this ability to heal injured tissues, organs or body parts, their primary functions being:

Regenerative medicine aims to use adult or embryonic stem cells to replace or regenerate human cells, tissue, or organs and restore normal function.

These adult stem cells are commonly referred to as «repair cells» for their ability to heal injured organs or body parts, their primary functions being:

How do adult stem cells communicate with their local environment (i.e. niche) and how is the system coordinated to dictate stem cell function?

These adult stem cells are commonly referred to as «repair cells» for their ability to heal injured tissues, organs or body parts, their primary functions being:

Utilizing the powerful healing cells found in fat tissue, adult stem cell therapy for stroke offers a new approach by opening the door to brain repair for the chance at improved function, symptoms and quality of life.

established that MAO loss led to prostate atrophy with reduced prostate basal and stem / progenitor cell activity in adult mice, thereby providing insight into the maintenance of prostate structure and function.

Specifically, we're focused on stem cell maturation — taking a cell from an immature to a more mature state so that it acts as a better substrate for adult tissue functions.

In a paper being published online today in the scientific journal Cell Stem Cell, Sheng Ding, PhD, reveals efficient and robust methods for transforming adult skin cells into neurons that are capable of transmitting brain signals, marking one of the first documented experiments for transforming an adult human's skin cells into functioning brain cells.