Not exact matches
But just how close
adult and reprogrammed
stem cells can come to matching the capabilities of embryonic
stem cells has become a contentious question in the debate over whether the federal government should continue funding research on embryonic
lines.
In one promising approach, cellular reprogramming,
stem cells can be generated by fusing
adult skin
cells with embryonic
stem cells from existing
cell lines.
During the last decade, some researchers have claimed that primordial follicles in
adult mouse ovaries turn over and that females use
adult germ -
line stem cells to constantly resupply the follicle pool and sustain ovulation.
It performs this critical service in embryonic development, growing organisms and in a few specialized
adult cell lines, including
stem cells.
Researchers compared induced pluripotent
stem cells lines reprogrammed from different
adult cell types that have been previously differentiated from embryonic
stem cells.
The only
stem cell research he would permit, Bush said, was research using existing embryonic
lines as well as so - called
adult stem cells, which occur in anyone of any age.
L: We use
adult stem cells, and we use the human embryonic
cell lines that the government has already approved.
Recent studies have shown how to reprogram
adult cells into non-embryonic
stem cell lines called induced pluripotent
stem cells — «pluripotent» meaning that they could give rise to almost any category of
cell.
First, a hair follicle contains epithelial
cells — a
cell type that
lines the body's vessels and cavities — as well as a specific kind of
adult stem cell called dermal papillae.
During the next five years, KOMP2 will transform the knockout mouse embryonic
stem (ES)
cells into
adult mice for 2,500
lines of well - characterized knockout mice strains, and IMPC will create about 2,500 additional knockout mouse strains.
Sophia Millonigg (Eckmann, MPG)-- «The translational activator complex GLD - 4 / GLS - 1 regulates germline
stem cell self - renewal and differentiation in the
adult C. elegans germ
line» (2013)
Faculty Henri Jasper, PhD has already extended lifespan and healthspan in fruit flies by enhancing the regenerative capacity of the
adult stem cells that
line their mid-gut.
My post-doctoral work on the identification of genes required for normal germ
line development and fertility led to the discovery that the germ
line is exquisitely sensitive to mutations in components of the mitotic spindle that have the potential to lead to aneuploidy — this sensitivity may also extend to embryonic and
adult stem cells.
Reprogramming
adult cells to function like embryonic
stem cells is one way researchers hope to create patient - specific
cell lines to regenerate tissue or to study specific diseases in the laboratory.
Scientists from the Research Department of Cryo - Save Group NV together with the University of Cologne (DE) have developed a new scientifically validated method to collect
adult mesenchymal
stem cells («MSCs») from the
lining of umbilical cord tissue.
Various
cell types have been examined for use in RPE
cell replacement including immortalized
cell lines, such as the human RPE
cell line, ARPE19 [2], sheets of
adult RPE [3], foetal RPE [4], RPE derived from human embryonic
stem cells (HESC - RPE)[5]--[10] and many non-RPE
cells lines [11]--[15].
We derived a fibroblast
line from a skin biopsy from a healthy
adult male (HUF1)(Figure 1A) and used immunocytochemistry to characterize the expression of
cell surface markers commonly expressed on pluripotent
stem cells (Figure 1B, C and D).