Reduction of endogenous striatal htt using siRNA in rats expressing Htt171 - 82Q had no further detrimental effect on neuronal survival nor htt inclusion load indicating that partial inactivation of endogenous WT htt in
the adult striatum (~ 50 %) had no major impact on the course of HD pathology (Drouet et al, 2009).
Not exact matches
When
adults learn hierarchical rules, Frank and Collins have combined experimental data with computer models of brain function to suggest, that the key circuit involved is a connection between the PFC and another region called the
striatum.
Activation of μ - opioid receptors in the dorsal
striatum is necessary for
adult social attachment in monogamous prairie voles.
In contrast to this relatively stable expression, when juvenile birds sang, FoxP2 was acutely down - regulated in area X relative to the surrounding
striatum (Fig. 3), similar to what we previously reported for
adult birds [21].
Infusion of Brain - Derived Neurotrophic Factor into the Lateral Ventricle of the
Adult Rat Leads to New Neurons in the Parenchyma of the
Striatum, Septum, Thalamus, and Hypothalamus