«There are still many questions left to answer but we now know that oxygen poor environments, like those often found in
advanced human breast cancers serve as nurseries for the birth of cancer stem cells,» says Gregg Semenza, M.D., Ph.D., the C. Michael Armstrong Professor of Medicine and a member of the Johns Hopkins Kimmel Cancer Center.
Not exact matches
Three - dimensional models of living tissue will
advance understanding of
human breast development as well as the growth of
breast cancer.
Humans have an ortholog of the murine Nrk gene, and considering that the gene expression pattern in
breast tumor in Nrk mutant mice was similar to that in
human luminal B
breast cancer, the findings of this study may lead to further understanding of the mechanisms of
human breast cancer suppression and to
advances in its diagnosis and therapy.
On Capitol Hill last week, Weinberg, an expert in the molecular biology of
cancer, pointed out to the Congressional Biomedical Research Caucus that the major
advances in understanding
human cancer genetics had come, not from studying
breast tissue, but from studying cow warts, worm vulvas, fruitfly retinas, and a chicken virus.
Dr. Jos Jonkers» research group studies the genetic basis of
human breast cancer, using
advanced mouse models for p53 - induced
breast cancer, BRCA1 - and BRCA2 - associated hereditary
breast cancer, and E-cadherin mutated invasive lobular carcinoma.
«In particular, his approach can be thought of as a very
advanced biological therapy for the treatment of
breast cancer; one that uses viruses, which are better recognized to cause disease, to treat
human breast cancers.»
Mucosal melanomas with mutations in CDK4 may respond to palbociclib or ribociclib, which have demonstrated activity in
advanced hormone receptor — positive,
human epidermal growth factor receptor 2 — negative
breast cancer.