The researchers now have plans to conduct further work to explore the safety and effectiveness of the approach in vivo and in
advanced lung tumor mouse models.
Not exact matches
«What is particularly encouraging is that we are now able to select, based on features in the
tumor, approximately a quarter of
advanced lung cancer patients who can receive immunotherapy as their initial treatment.
An old idea of retreating
lung tumors with radiation is new again, especially with the technological
advances seen in radiation oncology over the last decade.
If hypofractionated radiation with curative intent can reduce the treatment time for
lung cancer patients by half with no greater toxicity, and with equivalent — if not better —
tumor control and survival outcomes, this research could result in a change in the paradigm of how a large subset of locally
advanced NSCLC patients are treated.»
«FDG PET shows
tumor DNA levels in blood are linked to NSCLC aggressiveness: Insights derived from FDG PET could improve treatment selection for patients with
advanced non-small cell
lung cancer.»
Italian researches have demonstrated a better way of determining the aggressiveness of
tumors in patients with
advanced non-small cell
lung cancer (NSCLC).
Epidermal growth factor receptor (EGFR) mutations found in the circulating free
tumor DNA (ctDNA) from the plasma of
advanced non-small cell
lung cancer (NSCLC) patients correlates well with the EGFR mutations from patient - matched
tumor tissue DNA.
In a study of 124 patients with
advanced breast,
lung, and prostate cancers, a new, high - intensity genomic sequencing approach detected circulating
tumor DNA at a high rate.
«Metastatic brain
tumors — often from
lung, breast or skin cancers — are the most commonly observed
tumors within the brain and account for about 40 percent of
advanced melanoma metastases.
«Metastatic brain
tumors — often from
lung, breast or skin cancers — are the most commonly observed
tumors within the brain and account for about 30 percent of
advanced breast cancer metastases,» says Khalid Shah, MS, PhD, director of the Molecular Neurotherapy and Imaging Laboratory in the MGH Departments of Radiology and Neurology, who led the study.
An anti-PD-1 antibody developed by Bristol - Myers Squibb generates excitement with results from a phase I trial showing that, among 236 patients with various types of cancer, the treatment shrank
tumors in 28 percent of melanoma patients, 30 percent of patients with kidney cancer, and 18 percent of patients with
advanced non-small cell
lung cancer.
For more information regarding Bristol - Myers Squibb Clinical Trial participation, please visit www.BMSStudyConnect.com Inclusion Criteria: • Early stage IB - IIIA, operable non-small cell
lung cancer, confirmed in tissue • Lung function capacity capable of tolerating the proposed lung surgery • Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 - 1 • Available tissue of primary lung tumor Exclusion Criteria: • Presence of locally advanced, inoperable or metastatic disease • Participants with active, known or suspected autoimmune disease • Prior treatment with any drug that targets T cell co-stimulations pathways (such as checkpoint inhibitors) Other protocol defined inclusion / exclusion criteria could a
lung cancer, confirmed in tissue •
Lung function capacity capable of tolerating the proposed lung surgery • Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 - 1 • Available tissue of primary lung tumor Exclusion Criteria: • Presence of locally advanced, inoperable or metastatic disease • Participants with active, known or suspected autoimmune disease • Prior treatment with any drug that targets T cell co-stimulations pathways (such as checkpoint inhibitors) Other protocol defined inclusion / exclusion criteria could a
Lung function capacity capable of tolerating the proposed
lung surgery • Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 - 1 • Available tissue of primary lung tumor Exclusion Criteria: • Presence of locally advanced, inoperable or metastatic disease • Participants with active, known or suspected autoimmune disease • Prior treatment with any drug that targets T cell co-stimulations pathways (such as checkpoint inhibitors) Other protocol defined inclusion / exclusion criteria could a
lung surgery • Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 - 1 • Available tissue of primary
lung tumor Exclusion Criteria: • Presence of locally advanced, inoperable or metastatic disease • Participants with active, known or suspected autoimmune disease • Prior treatment with any drug that targets T cell co-stimulations pathways (such as checkpoint inhibitors) Other protocol defined inclusion / exclusion criteria could a
lung tumor Exclusion Criteria: • Presence of locally
advanced, inoperable or metastatic disease • Participants with active, known or suspected autoimmune disease • Prior treatment with any drug that targets T cell co-stimulations pathways (such as checkpoint inhibitors) Other protocol defined inclusion / exclusion criteria could apply
Inclusion Criteria: • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 • Have histologically or cytologically confirmed
advanced or metastatic non-small cell
lung cancer (NSCLC)(Stage IIIb or greater) • Measurable disease, as defined by Response Evaluation Criteria in Solid
Tumors (RECIST) 1.1 • Known PD - L1
tumor status as determined by an immunohistochemistry (IHC) assay performed by the central laboratory on tissue obtained at Screening • A woman of childbearing potential must have a negative highly sensitive serum (beta - human chorionic gonadotropin [beta - hCG]-RRB- at Screening within 14 days prior to study drug administration Inclusion Criteria for Crossover: • Participants must have been randomized to Arm A of the study and had radiographic disease progression according to RECIST 1.1 • Participants must have a mandatory biopsy at the time of disease progression according to RECIST 1.1 prior to crossing over.
In the study, the researchers tested phenformin as a chemotherapy agent in genetically - engineered mice lacking LKB1 and which had
advanced stage
lung tumors.
In 2010, CRI researchers Drew Pardoll, M.D., Ph.D., Susan Topalian, M.D., and colleagues completed a phase I study showing that a PD -1-specific monoclonal antibody induces frequent
tumor regressions in patients with
advanced melanoma, renal cancer,
lung cancer, and colon cancer with very low rates of toxicity.
To translate
advances in our understanding of molecular mechanisms of oncogenesis and
tumor progression into novel therapeutic strategies.With primary focus on
lung cancer, melanoma, and lymphoma / leukemia, we will use the strength of in - depth molecular and phenotypic characterization of
tumor heterogeneity to identify new targets and translate those into new therapeutic opportunities.
Not all cases are so
advanced that
tumors in the
lungs can be detected.
Cats with
advanced lung involvement at the time the
tumor is diagnosed have a median survival time of only one month.
A few dogs are diagnosed with
advanced metastasis (
tumors that have spread to elsewhere in the body, such as the
lungs and lymph nodes) and might be feeling ill from their
tumors when they come for treatment.