Sentences with phrase «advanced preclinical»

Development of advanced preclinical models are needed to further elucidate the complex mechanisms underlying asthma exacerbation and investigate new therapeutic strategies.

PsychoGenics has pioneered the translation of rodent behavioral responses into robust, high throughput, high content phenotyping and its drug discovery platforms, SmartCube ®, NeuroCube ®, and PhenoCube ® have led to shared risk partnerships with major pharma companies such as Sunovion and Roche and resulted in the discovery of several novel compounds now in clinical trials or advanced preclinical development.

«Future studies will aim to explore the relationship between SND1 and STAT3, identify additional microRNAs that may be relevant to malignant glioma and explore the effects of drugs that block SND1 expression in more advanced preclinical models.»

Wake Forest Innovations can help you solve these medical problems by getting you access to the researchers and clinicians at Wake Forest Baptist Medical Center to advance your preclinical or clinical research — from stroke and epilepsy to pain and addiction and everything in between.

Not exact matches

In a paper published in Advanced Functional Materials, the research team reports on the new material's key properties, many of which can be finely tuned, and on the results of using the material in preclinical models of wound healing.

Arrowhead Pharmaceuticals and Wave Life Sciences have a number of preclinical programs in play, though none have advanced nearly as far as Alnylam.

Preclinical animal models are available that will facilitate the study of these important interactions to advance our knowledge, so that the obesity - and diabetes - driven burden of PDAC can be curbed,» commented Dr. Eibl.

The group plans to continue exploring the mechanics of SF3B1 while also pushing forward with the preclinical work needed to form the rational basis for targeting this gene in patients with advanced mucosal melanoma.

The findings of multiple in vivo preclinical studies published online in Blood Advances, a Journal of the American Society of Hematology (ASH), indicate that this therapy could potentially treat multiple cancers, including non-Hodgkin lymphoma (NHL), multiple myeloma (MM), and acute myeloid leukemia (AML).

«Advanced viral gene therapy eradicates prostate cancer in preclinical experiments.»

Wake Forest Innovations gives you access to leading clinical and preclinical experts who partner with industry to advance medical technologies and research.

Many factors may cause differences between current expectations and actual results including unexpected safety or efficacy data observed during preclinical or clinical studies, clinical trial site activation or enrollment rates that are lower than expected, changes in expected or existing competition, changes in the regulatory environment, failure of Syndax's collaborators to support or advance collaborations or product candidates and unexpected litigation or other disputes.

CMIIT's mission is to engage the molecular imaging community and leverage the SNMMI infrastructure to advance the adoption of emerging molecular imaging technologies and probes in preclinical and clinical applications.

They found that injecting patient - derived, brain - seeking melanoma cells into the carotid artery of these preclinical models resulted in the formation of many metastatic tumors throughout the brain, mimicking what is seen in advanced melanoma cancer patients.

These forward - looking statements are based on management's current assumptions and expectations and involve risks, uncertainties and other important factors, specifically including those relating to Lexicon's ability to successfully conduct preclinical development of its drug candidates and advance such candidates into clinical development, achieve its operational objectives, obtain patent protection for its discoveries and establish strategic alliances, as well as those relating to manufacturing, the regulatory process, intellectual property rights, and the therapeutic or commercial value of its drug candidates, that may cause Lexicon's actual results to be materially different from any future results expressed or implied by such forward - looking statements.

Nanotheraputics for Antibiotic Resistent Emerging Bacterial pathogens (NAREB) European Research Infrastructures for Poverty Related Diseases (EURIPED) Biomarkers for enhanced vaccines immunosafety (BioVacSafe) European network of vaccine research and development TRANSVAC Advancing novel and promising TB vaccine candidates from discovery to preclinical and early clinical development (TBVAC2020)

[21] In the recently presented FLAURA study, in which osimertinib was used in untreated patients with advanced EGFR - mutant NSCLC, the HR for systemic disease control and CNS control similarly favored osimertinib over erlotinib or gefitinib, supporting the preclinical data that showed osimertinib's penetration across the BBB and providing support for using this agent in first - line management of EGFR - mutant patients with brain metastases.

Moderna's preclinical work for mRNA - 1325 was funded through a grant from the Defense Advanced Research Projects Agency (DARPA).

Dual targeting of the epidermal growth factor receptor using the combination of cetuximab and erlotinib: preclinical evaluation and results of the phase II DUX study in chemotherapy - refractory, advanced colorectal cancer.

All in all, these were very encouraging preclinical results, and AFF 1 was advanced to human testing as PD01A.

This study is a beautiful example of multidisciplinary team science at partnering academic institutions advancing a life - saving therapeutic from the laboratory, to preclinical studies, deftly though complex regulatory pathway, to the clinic and — with final FDA approval — hopefully into the marketplace.

Another mouse preclinical screening trial targeted the symptomatic stage (between 9 and 11 months)[44] and a study with a plant extract [99] used 23 - to 24 - month - old mice, but to our knowledge no chemically defined AD drug candidate has been tried at the more pathologically advanced stage used in this study.

Advance to the Clinic On December 11, 2013, presumably on the strength of these sweeping (but then - unpublished) preclinical data, the pharmaceutical giant Roche announced:

Today our rich collection of arthritis mouse models is widely used for the preclinical evaluation of the efficacy of anti-arthritic pharmaceuticals and offer an ideal platform for establishing proof of concept for novel technological advances.

The phenotyping department of PHENOMIN - ICS is advancing a technical platform for functional characterization of preclinical models of human diseases with respect to both genetic understanding of pathophysiological mechanisms and the assessment of drug therapies.

As the Global HIV Vaccine Product Manager for the US Army, Dr. Ake advances the development of HIV vaccine candidates in preclinical and early clinical studies.

These new preclinical studies provide support for advancing the Ad26 / MVA prime - boost vaccine candidate into clinical development.

Southern Research Institute is a not - for - profit 501 (c)(3) scientific research organization founded in 1941 that conducts preclinical drug discovery and development, advanced engineering research in materials, systems development, and environment and energy research.

Associate Senior Lecturer (Assistant Professor) in Molecular Medicine: Translation of preclinical regenerative medicine into advanced therapy medicinal products (ATMP)(PA2018 / 376)

We believe that this 10 - lipid phospholipid biomarker panel reflects the breakdown of neural cell membranes in those individuals destined to develop advanced moderate cognitive impairment or Alzheimer's disease and may mark the transition between preclinical states where synaptic dysfunction and early neurodegeneration give rise to subtle cognitive changes.»

These reference standards and limited feeding trials are, like the basic pharmacology and preclinical testing of pharmaceuticals, not perfect, and it is certainly likely that advances in our understanding of dogs» nutritional needs as well as epidemiologic studies of dogs fed commercial diets will uncover changes that need to be made in the formulations of commercial diets.