Sentences with phrase «advanced solid tumors»
The drug was generally well tolerated, and several of the 26 patients with advanced solid tumors experienced stable disease for greater than six months.
sciencedaily.com
Additional clinical trial data later this year on Tesaro's key drug, Niraparib, which targets advanced solid tumors in ovarian and breast cancers, could help narrow the valuation gap, the people said.
The Phase I clinical trial of OMP - 54F28 (FZD8 - Fc) is an open - label dose escalation study in patients with advanced solid tumors for which there was no remaining standard curative therapy.
The trial «Niraparib Plus Carboplatin in Patients with Homologous Recombination Deficient Advanced Solid Tumor Malignancies» is not yet recruiting patients for enrollment.
Alexander Drilon, MD, Assistant Attending Physician in the Developmental Therapeutics Clinic and the Thoracic Oncology Service, will report results from the international phase I STARTRK - 1 and STARTRK - 2 clinical trials, which assessed entrectinib as a treatment for patients with advanced solid tumors harboring gene rearrangements and of which he is principal investigator at MSK.
MSX - 122 Administered Orally in Patients With Refractory Metastatic or Locally Advanced Solid Tumors.
Data from a phase II study of cabozantinib (XL184) in patients with advanced solid tumors show that the drug has activity in both bone and soft tissue.
He oversees a number of clinical trials at City of Hope, which evaluate new drugs to treat advanced solid tumors.
Using a fluorescent protein to detect Rgs16 expression, the investigators found that this gene is induced by pancreatic tumor formation starting from its earliest manifestation as ductal neoplasm all the way to advanced solid tumor in a spatially and temporally coincidental manner.
Trial # 5: Combined autophagy and HDAC inhibition: A phase I safety, tolerability, pharmacokinetic, and pharmacodynamic analysis of HCQ in combination with the HDAC inhibitor vorinostat in patients with advanced solid tumor.
Trial # 2: Phase I trial of HCQ with dose - intense temozolomide in patients with advanced solid tumors and melanoma
Dent is collaborating with Massey clinical researchers to propose a study investigating the effectiveness of the combination of neratinib, sorafenib and pemetrexed in all advanced solid tumors.
Another key finding was observing the inhibitor effect on tumor models with a gene PTEN deficiency as a biomarker — of huge interest because PTEN, a tumor suppressor, is known to be defective in as many as half of all advanced solid tumor cancers.
Phase I Clinical Trial of VX - 970 in Combination with the Topoisomerase I Inhibitor Irinotecan in Patients with Advanced Solid Tumors
A Phase II Study of the PARP Inhibitor Olaparib (AZD2281) Alone and in Combination with AZD1775, AZD5363, or AZD2014 in Advanced Solid Tumors - OLAPCO (OLAParib COmbinations)
My Pathway: An Open - Label Phase IIA Study Evaluating Trastuzumab / Pertuzumab, Erlotinib, Vemurafenib / Cobimetinib, Vismodegib, Alectinib, and Atezolizumab in Patients Who Have Advanced Solid Tumors with Mutations or Gene Expression Abnormalities Predictive of Response to One of These Agents
A Phase 1 Open - Label, Dose - Finding Study Evaluating Safety and Pharmacokinetics of FPA144 in Patients with Advanced Solid Tumors
«Avelumab generally was well tolerated and had a manageable safety profile in a large population of patients with advanced solid tumors,» the authors concluded.
The Maharaj Institute has an FDA IND clinical trial protocol (08001 - BMSCTI) for investigating a novel cancer therapy using transfusions of white blood cells from healthy donors to patient with advanced solid tumors.
Intralesional adenovirus - mediated interleukin - 2 gene transfer for advanced solid tumors and melanoma.
Combined autophagy and HDAC inhibition: a phase I safety, tolerability, pharmacokinetic, and pharmacodynamic analysis of hydroxychloroquine in combination with the HDAC inhibitor vorinostat in patients with advanced solid tumors.