Patients with epidermal growth factor receptor (EGFR) expressing
advanced squamous non-small-cell lung cancer benefit most from necitumumab added to gemcitabine and cisplatin chemotherapy, according to a subgroup analysis from the SQUIRE trial presented today at the European Lung Cancer Conference (ELCC) 2016 in Geneva, Switzerland.
Not exact matches
For the new trial, hospitals enrolled patients with
advanced,
squamous non-small cell lung cancer whose disease had progressed despite initial chemotherapy.
The current standard of care for
advanced head and neck
squamous cell carcinoma involves chemotherapy and radiation.
Researchers have found that people with
advanced head and neck
squamous cell carcinoma and the KRAS - variant inherited genetic mutation have significantly improved survival when given a short course of the drug cetuximab in combination with standard chemotherapy and radiation.
NRG Oncology researchers recently developed and validated a nomogram that can predict 2 - year and 5 - year overall survival (OS) and progression - free survival (PFS) for patients with local - regionally
advanced oropharyngeal
squamous cell carcinoma (OPSCC) treated primarily with radiation - based therapy.
Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with
advanced, refractory
squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single - arm trial.
In March, the U.S. Food and Drug Administration approved nivolumab for patients with
advanced (metastatic)
squamous non-small cell lung cancer.
Currently, the CDK9 inhibitor flavopiridol is being evaluated in several phase I and II clinical trials for its anti-cancer effects either as a single agent or in combination with other drugs in treatment of esophageal cancer, B - cell chronic lymphocytic leukemia, endometrial carcinoma, recurrent / metastatic
squamous cell carcinoma and most relevantly, previously treated locally
advanced or metastatic breast cancer (http://www.cancernetwork.com/review-article/current-clinical-trials-flavopiridol/page/0/2).
Cutaneous
squamous cell carcinomas are known to
advance quickly into tumors and resist healing with time.
Filed Under: Clinical Trials, Veterinary
Advances / Clnical Trials Tagged With: cats with cancer, clinical trial for cats with cancer, lessons from a paralyzed dog, National Pet Cancer Awareness Month, SCC oral cancer trial for cats,
squamous cell cancer trial for cats