Sentences with phrase «advanced stage disease»

The majority of these deaths are due to advanced stage disease that has spread or metastasized to other sites.

«The best way to apply immunotherapy as cancer prevention is during tumor dormancy to prevent advanced stage disease.»

Not exact matches

A newborn is not fully sentient, nor is a person in an advanced stage of Alzheimer's disease.

Radiologists came from across the hospital to peer at the results, disbelieving: A perfectly healthy 21 - year - old nonsmoker with no family history of the disease had lung cancer, which three days later would be diagnosed as stage IV, the most advanced form.

Patients with early - stage and advanced OA, RA or other inflammatory joint disease were recruited for the study alongside a control group of those with good skeletal health, with plasma and synovial fluid samples from both groups being analysed using mass spectrometry.

«Based on the results of this study, the side of origin of CC [colon cancer](left vs. right) should be acknowledged as a criterion for establishing prognosis in both earlier and advanced stages of disease.

Whereas Murphy's patients were selected for the recent onset of symptoms, the children arriving at Stanford had progressed to advanced stages of the disease without appropriate treatment.

Those suffering from advanced stages of macular degeneration may by the end of this year be able to halt and even reverse vision loss caused by the age - related eye disease.

«The majority of patients with chronic kidney disease, particularly those in the more advanced stages who require dialysis, exhibited some degree of loss of their sense of smell, which correlated with reduced nutritional status,» says Teodor Paunescu, PhD, of the MGH Division of Nephrology, corresponding author of the study.

Therefore, screening could result in over-treatment and consequently in decreased quality of life and ability to function in older breast cancer patients, without lowering the incidence of advanced stage breast cancer or deaths from the disease,» he said.

«Although there is a high risk of progression to decompensated cirrhosis and liver cancer among patients with advanced fibrosis, limiting access to people who have already progressed to late - stage disease as compared to treating earlier to prevent these liver - related complications seems counter-intuitive as a public health strategy.»

Trial participants have advanced disease with geography atrophy — considered a late stage in dry AMD — and very poor visual abilities.

«We are evaluating patient and disease factors that affect the value of FDG PET / CT for systemic staging of locally advanced breast cancer,» said study coauthor Molly Parsons.

A study published March 7th by Cell Press in the journal Cell reveals that a compound derived from fats found in fish oils prevents death in influenza - virus - infected mice, even at advanced stages of disease.

The most common and deadliest form of pancreatic cancer — pancreatic adenocarcinoma — has a five - year survival rate of 12 to 14 percent for early - stage disease and 1 to 3 percent for advanced disease, according to the American Cancer Society.

Surgery is not the panacea that patients frequently hope for, and the majority of pancreatic cancer patients aren't even eligible due to the advanced stage of the disease at presentation.

Although CRC affects all racial and ethnic groups, African Americans carry an excessive burden of disease with the highest overall incidence, highest incidence of advanced stage at presentation, highest mortality, and lowest survival rates compared to any other ethnic or racial group.

More than 80 percent of women with advanced stage high - grade serous ovarian cancer experience relapses even after repeated surgeries and multiple rounds of chemotherapy, and this effective new approach to treat the disease could be a major step forward in preventing cancer from returning.

This time, the disease was at a more advanced stage and had spread to his abdomen.

Researchers have developed a method to measure how the brain responds to electrical stimulation and use the response to maximize efficacy of deep brain stimulation (DBS)-- a therapy that has been successfully used to treat advanced stages of Parkinson's disease.

You might expect that the next advances in cancer prevention will mean better and more frequent tests that will pick up tumors at the earliest possible stage, followed by a blitzkrieg treatment that will completely wipe out the disease.

It is often considered to be something of a «silent killer» because most people feel well, unaware that they have a liver problem, until the disease is at an advanced stage.

Even when animals began treatment at advanced stages of the disease, AC1903 was able to prevent further podocyte loss and suppress proteinuria, indicating restored kidney function.

However, as most patients are diagnosed at an advanced stage of disease, many will experience a relapse of their disease.

Locally advanced pancreatic cancer has the lowest survival rate of any solid tumor, with a cumulative five - year survival rate of only 4 percent for all stages of disease.

The high mortality rate is mainly due to late diagnosis of the disease, when it is already in an advanced stage.

The new studies find high activity with investigative drugs for advanced melanoma, and show for the first time that ipilimumab, a treatment already approved for advanced melanoma, can substantially decrease the risk of melanoma recurrence in certain patients with earlier - stage disease.

Moffitt Cancer Center researchers participated in an international phase 3 study that demonstrated that a drug called ipilimumab improves the relapse - free survival of advanced stage melanoma patients rendered free of disease surgically but at high risk for relapse.

«On the flip side of that, I would say that if you are able to demonstrate anti-cancer activity in a dog with very advanced disease, then it would be likely that you would have equivalent or better activity in people with a less advanced stage of the disease,» Fan said.

This disease causes pain and stiffness of the joints, and at advanced stages, limitations to the movement or bending of injured joints.

Our work continues as we advance new methods and understanding for detecting cancers at their earliest stages, universal flu vaccines, and autoimmune diseases like multiple sclerosis.

Dogs diagnosed with bone cancer often arrive at the clinic at a very advanced stage of the disease, whereas in humans, bone cancer is usually detected early because people complain about the pain and have it investigated.

For more information regarding Bristol - Myers Squibb Clinical Trial participation, please visit www.BMSStudyConnect.com Inclusion Criteria: • Early stage IB - IIIA, operable non-small cell lung cancer, confirmed in tissue • Lung function capacity capable of tolerating the proposed lung surgery • Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 - 1 • Available tissue of primary lung tumor Exclusion Criteria: • Presence of locally advanced, inoperable or metastatic disease • Participants with active, known or suspected autoimmune disease • Prior treatment with any drug that targets T cell co-stimulations pathways (such as checkpoint inhibitors) Other protocol defined inclusion / exclusion criteria could apply

Because of the success of early treatment, some research suggests that people with liver diseases should routinely be screened for HE through cognitive tests so that HE can be caught and treated before it progresses into the more advanced stages.

Inclusion Criteria: • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 • Have histologically or cytologically confirmed advanced or metastatic non-small cell lung cancer (NSCLC)(Stage IIIb or greater) • Measurable disease, as defined by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 • Known PD - L1 tumor status as determined by an immunohistochemistry (IHC) assay performed by the central laboratory on tissue obtained at Screening • A woman of childbearing potential must have a negative highly sensitive serum (beta - human chorionic gonadotropin [beta - hCG]-RRB- at Screening within 14 days prior to study drug administration Inclusion Criteria for Crossover: • Participants must have been randomized to Arm A of the study and had radiographic disease progression according to RECIST 1.1 • Participants must have a mandatory biopsy at the time of disease progression according to RECIST 1.1 prior to crossing over.

Men with these mutations are more likely than non-carriers to contract aggressive, lethal prostate cancer, to be diagnosed at a more advanced stage and to ultimately die of the disease, researchers say.

Twice as many men are affected as women and the disease is often not diagnosed until an advanced stage.

Courtesy of Intermountain Medical Center Patients with hepatitis C who suffer from advanced stages of liver disease have renewed hope, thanks to findings by researchers who have discovered that a new drug significantly reduces their risk of deat...

Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) exist along a continuous disease spectrum starting with early - stage MDS, which may progress to advanced MDS, AML, cured AML or resistant AML.

By characterizing mutations from secondary AML tumors in the MDS precursors for the same patient, the authors reconstructed the clonal architecture of the disease from early to advanced stages.

To more accurately reflect the clinical setting, we used an alternative screening strategy involving the treatment of AD mice at a stage in the disease when pathology is already advanced.

The presentations focused on advances in the diagnosis, management, and treatment of genetic conditions during all stages of life, from prenatal conditions to Alzheimer Disease.

Following the development of symptoms a patient is most infectious in the advanced stages of disease, when they are shedding millions of virus particles in bodily fluids, primarily vomit and diarrhoea.

He gave a similarly negative reply to a question about the use of the vaccine in patients undergoing deep brain stimulation (DBS) for PD, «given the mode of action of disease modifiers,» because DBS is typically reserved to patients in relatively advanced stages of the disease.

Results from these behavioral assays show that J147 has the ability to rescue the cognitive decline and disinhibition phenotype associated with AD when administered at an extremely late stage in the disease progression when pathology is already far advanced.

In summary, we demonstrate similar neurological / motor function deficits in SOD1 and PFN1 mice, both exhibiting clinically - relevant attributes of Amyotrophic lateral sclerosis (ALS), with more advanced computer vision systems identifying distinctive behavioral patterns and discriminating the phenotype at very early disease stages in both models.

Immune - based strategies to treat pancreatic cancer during the early stages of development, as well as new immunological approaches to treat advanced disease, are showing significant promise where other approaches have failed.

Neuroblastoma for example, sometimes we see these in stage four, very advanced disease, but a bigger question that we really need to understand is why very early cancers sometimes progress and sometimes don't and as our detection...

When considered by stage, the 5 - year survival rates are 99 % for localized disease and 85 % for regionally advanced disease that may have spread to neighboring lymph nodes.

Lung cancer is the leading cause of cancer mortality worldwide, suffering from a late stage of disease at the time of diagnosis and a paucity of effective therapeutic strategies to treat advanced tumours.