Sentences with phrase «adverse effect level»

The lowest observed adverse effect level tends to go down as more sensitive tests of effects are developed.

The No Observed Adverse Effect Level (NOAEL) is 8.8 mg / kg / day (for male dogs) where doses at 29 mg / kg / day resulted in smaller testicles in male dogs when fed boric acid at this level for months.

Not exact matches

These risks and uncertainties include competition and other economic conditions including fragmentation of the media landscape and competition from other media alternatives; changes in advertising demand, circulation levels and audience shares; the Company's ability to develop and grow its online businesses; the Company's reliance on revenue from printing and distributing third - party publications; changes in newsprint prices; macroeconomic trends and conditions; the Company's ability to adapt to technological changes; the Company's ability to realize benefits or synergies from acquisitions or divestitures or to operate its businesses effectively following acquisitions or divestitures; the Company's success in implementing expense mitigation efforts; the Company's reliance on third - party vendors for various services; adverse results from litigation, governmental investigations or tax - related proceedings or audits; the Company's ability to attract and retain employees; the Company's ability to satisfy pension and other postretirement employee benefit obligations; changes in accounting standards; the effect of labor strikes, lockouts and labor negotiations; regulatory and judicial rulings; the Company's indebtedness and ability to comply with debt covenants applicable to its debt facilities; the Company's ability to satisfy future capital and liquidity requirements; the Company's ability to access the credit and capital markets at the times and in the amounts needed and on acceptable terms; and other events beyond the Company's control that may result in unexpected adverse operating results.

We believe that imposing this burden on our men and women in uniform would undermine recruiting and retention, impact leadership at all levels, have adverse effects on the willingness of parents who lend their sons and daughters to military service, and eventually break the All - Volunteer Force.

Since social media has become an integral part of everyday life for many young adults, it is important to address its adverse effects on stress levels and well - being.

EFSA Limits 3 - MCPD Concentration Levels Due to the growing concern over the potential adverse health effects associated with 3 - monochloropropanediol (3 - MCPD), the European Food Safety Authority (EFSA) has limited concentration levels of this chemical byproduct in certain foods like hydrolyzed vegetable proLevels Due to the growing concern over the potential adverse health effects associated with 3 - monochloropropanediol (3 - MCPD), the European Food Safety Authority (EFSA) has limited concentration levels of this chemical byproduct in certain foods like hydrolyzed vegetable prolevels of this chemical byproduct in certain foods like hydrolyzed vegetable proteins.

«A growing body of research points to the potential for arsenic to cause adverse health effects at low levels.

They found that the BPA levels in humans are higher than the levels causing adverse effects in animal studies.

«Adverse effects of bupivacaine levels on the infant's motor organization, his ability to control his own state of consciousness and his physiological response to stress were also observed.»

It is thought, however, that levels of these fatty acids at levels greater than those found in human breast milk may have adverse effects on growth, survival, and neurodevelopment in other animals.

LactMed ® includes information on the levels of such substances in breast milk and infant blood, and the possible adverse effects in the nursing infant.

Meanwhile, an independent group of 38 BPA researchers who were not part of the panel but are considered experts on the chemical issued their own warning in the journal Reproductive Toxicology: Very low levels of exposure to the chemical can potentially pose adverse health effects, especially to a fetus.

In the last few decades it has been established beyond any reasonable doubt that bioeffects and some adverse health effects occur at far lower levels of RF... exposure where no heating... occurs at all; some effects are shown to occur at several hundred thousand times below the existing public safety limits where heating is an impossibility.»

And regarding the non-thermal effect, they hold that «to date, research does not suggest any consistent evidence of adverse health effects from exposure to radiofrequency fields at levels below those that cause tissue heating.»

In addition, there was no effect on breastfeeding duration when the pacifier was introduced at 1 month of age.280 A more recent systematic review found that the highest level of evidence (ie, from clinical trials) does not support an adverse relationship between pacifier use and breastfeeding duration or exclusivity.281 The association between shortened duration of breastfeeding and pacifier use in observational studies likely reflects a number of complex factors such as breastfeeding difficulties or intent to wean.281 A large multicenter, randomized controlled trial of 1021 mothers who were highly motivated to breastfeed were assigned to 2 groups: mothers advised to offer a pacifier after 15 days and mothers advised not to offer a pacifier.

In addition to being more highly exposed to As, children appear to be far more sensitive to the potential carcinogenic effects of As49, 50 and have a heightened risk for adverse growth, adverse immune response, and adverse neurodevelopmental outcomes,25,51 - 53 even at relatively low levels of exposure.24, 54 Our results indicate that consumption of rice and rice products increases infants» exposure to As and that regulation could reduce As exposure during this critical phase of development.

If the adverse effects of high bilirubin levels in newborns appear, there are different treatment options.

President Akufo - Addo was confident that these measures will enable the country attain a significant level of self - reliance, promote industrialisation and provide adequate cushion against the adverse effects of price shocks.

«Because these two chemicals have similar types of adverse health effects, our recommendation is that folks look at the individual or combined concentrations of PFOA and PFOS and compare that to the 70ppt level.»

The most common adverse side effects were lymphopenia (a condition of abnormally low levels of white blood cells called lymphocytes), neutropenia, blood platelet deficiency, and infection.

In order to achieve therapeutic levels at the pathological site, physicians need to deliver large amounts of the drug that may cause adverse effects to other organs in the body.

It's about determining efficacy (how well it works and how much is needed) and safety (at what level might the compound produce adverse effects), a risk - benefit curve.

«The important point here is that smooth projections of sea level rise do not capture this variability, so adverse effects of sea level rise may occur before they are predicted to happen,» Dutton said.

Or magnesium where the upper level is based on severe diarrhea, which is not life threatening, but an adverse effect.

The hazard quotient is the ratio of estimated specific exposure to a single chemical over a specified period to the estimated daily exposure level at which no adverse health effects are likely to occur.

«Of course, the long - term exposure to these levels of PCBs could lead to adverse effects to human health; however, a detailed toxicological study is needed in order to determine the effects.»

The UCSB team investigated the effect of exposure during pregnancy in this agriculturally dominated area and observed an increase in adverse outcomes accompanying very high levels of pesticide exposure.

The study finds that across Europe children do not receive an equal level of protection from the adverse effects of online marketing, given that marketing to children is regulated in a slightly different manner between countries and because parents apply different models of oversight of their children's online activities.

The authors speculate that possible explanations for this finding is that reflex tearing might help flush PM from the ocular surface, or that environmental PM10 levels currently in Korea are not high enough to induce adverse effects on the ocular surface.

Ambient levels of air pollution are known to be associated with a wide range of adverse health effects that particularly affect the respiratory and cardiovascular systems.

Ten of the 15 patients experienced adverse effects of the diet, which included constipation, weight loss, low blood sugar, high cholesterol in the blood and low sodium levels in the blood.

On the community level, many towns and cities have autonomously created action plans to prepare for the adverse effects of climate change.

Gulf War veterans with low - level exposure to chemical weapons show lasting adverse effects on brain structure and memory function, reports a study in the October Journal of Occupational and Environmental Medicine.

«The study showed that not only higher noise levels have a stressful effect and are harmful to health, but that lower noise levels can cause adverse health effects, too,» said Professor Annette Peters, director of the EPI II.

Reduction of htt to 50 % endogenous levels produces viable mice with no overt phenotypes (Duyao et al., 1995; Zeitlin et al., 1995) however more detailed evaluation has revealed deficits in cognition and motor behavior (Nasir et al., 1995) raising the possibility that lowered htt starting in development may have adverse effects in the mouse.

Three recent experimental studies focused on low consumption / exposure.949596 In one study, 29 smokers each consumed a single cigarette, immediately after which they had a significant decrease in blood vessel output power and significant increase in blood vessel ageing level and remaining blood volume 25 minutes later, as markers of atherosclerosis.94 In another study, human coronary artery endothelial cells were exposed to the smoke equivalent to one cigarette, which led to activation of oxidant stress sensing transcription factor NFR2 and up - regulation of cytochrome p450, considered to have a role in the development of heart disease.95 These effects were not seen when heart cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain cells.96

As a result, the levels of these drugs may be increased in the blood, and may cause increased effects or potentially serious adverse reactions.

NADH and ribose levels also improved substantially, with no adverse effects.

High levels of phytoestrogens and zinc - blocking phytic acid, plus additional neurotoxic compounds such as dieldrin, aluminum, fluoride and cadmium combine in soy to yield a veritable witches» brew that can have adverse effects on the brain during development and throughout life.

Modest improvement was reported without adverse effects, but no published information is yet available on blood glucose or blood ketone levels in the treated patients.

«no defined intake level at which potential adverse effects of protein was identified» and «there is no evidence that amino acids from usual or even high intakes of protein from foodstuffs present any risk.»

After eight weeks of treatment, both groups showed the same level of improvement in pain and functionality with only one big difference: In the drug group, 14 percent of the participants dropped out due to severe adverse effects; in the BCM - 95 curcumin group, not one person had to drop out.

The researchers suspect that the sudden change in blood calcium levels after taking a supplement brings about the adverse effect, instead of it being related to the total amount of calcium taken.

It seems it's accepted now that high salt can have adverse effects, «but whether very low sodium levels are beneficial is less well accepted,» she said.

Since blood levels of retinol - binding protein change with pregnancy, the serum retinol test can yield inaccurate results.22 Be aware that routine iron supplementation is not advisable during pregnancy, since an increased iron intake in women with an already adequate iron status may have adverse effects.

Having enough levels of these hormones is vital because an imbalance would cause a slew of adverse effects and may even result in serious diseases, such as hyperthyroidism, hypothyroidism, Hashimoto's disease and Graves» disease.

Many adverse effects occur only in the presence of higher testosterone levels, and still others are simply the consequences of the body's normal metabolism of testosterone.

Higher levels may cause adverse effects, and may be toxic in some cases (14).

One thing to note: I still have heavy whipping cream and real butter and they don't seem to have an adverse side effects on my leanness levels.

This study studied the relationship between plasma level of insulin - like growth hormone I (IGF - I), changes in lean body mass and in adipose mass, and adverse side - effects during human growth hormone (HGH) treatment of elderly men who had low IGF - I levels.