Sentences with phrase «adverse effects at»

Medication adverse effects at midtreatment, whether measured by severity or total number, were not significantly correlated with outcome.

I have seen no adverse effects at all.

For example, cod liver oil has concentrations of vitamin A and vitamin D that can have adverse effects at high doses.

It's nice to know there were no apparent adverse effects at even 27 cups of broccoli a day's worth of these cruciferous phytonutrients.

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

«The good thing is that it's not toxic to humans and has been shown to not have any adverse effects on human health,» said Gubler, a professor emeritus at Duke University and a former head of the CDC's dengue program.

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

Studies show more than 400 mg per day can put a person at risk of adverse effects.

These risks and uncertainties include competition and other economic conditions including fragmentation of the media landscape and competition from other media alternatives; changes in advertising demand, circulation levels and audience shares; the Company's ability to develop and grow its online businesses; the Company's reliance on revenue from printing and distributing third - party publications; changes in newsprint prices; macroeconomic trends and conditions; the Company's ability to adapt to technological changes; the Company's ability to realize benefits or synergies from acquisitions or divestitures or to operate its businesses effectively following acquisitions or divestitures; the Company's success in implementing expense mitigation efforts; the Company's reliance on third - party vendors for various services; adverse results from litigation, governmental investigations or tax - related proceedings or audits; the Company's ability to attract and retain employees; the Company's ability to satisfy pension and other postretirement employee benefit obligations; changes in accounting standards; the effect of labor strikes, lockouts and labor negotiations; regulatory and judicial rulings; the Company's indebtedness and ability to comply with debt covenants applicable to its debt facilities; the Company's ability to satisfy future capital and liquidity requirements; the Company's ability to access the credit and capital markets at the times and in the amounts needed and on acceptable terms; and other events beyond the Company's control that may result in unexpected adverse operating results.

For example, the expected timing and likelihood of completion of the proposed merger, including the timing, receipt and terms and conditions of any required governmental and regulatory approvals of the proposed merger that could reduce anticipated benefits or cause the parties to abandon the transaction, the ability to successfully integrate the businesses, the occurrence of any event, change or other circumstances that could give rise to the termination of the merger agreement, the possibility that Kraft shareholders may not approve the merger agreement, the risk that the parties may not be able to satisfy the conditions to the proposed transaction in a timely manner or at all, risks related to disruption of management time from ongoing business operations due to the proposed transaction, the risk that any announcements relating to the proposed transaction could have adverse effects on the market price of Kraft's common stock, and the risk that the proposed transaction and its announcement could have an adverse effect on the ability of Kraft and Heinz to retain customers and retain and hire key personnel and maintain relationships with their suppliers and customers and on their operating results and businesses generally, problems may arise in successfully integrating the businesses of the companies, which may result in the combined company not operating as effectively and efficiently as expected, the combined company may be unable to achieve cost - cutting synergies or it may take longer than expected to achieve those synergies, and other factors.

The fact that many advanced economies are suffering from deficient demand and have policy rates at or near the zero bound and that the U.S. dollar is a favored safe - haven asset may imply that adverse foreign demand shocks have a particularly strong effect on the value of the dollar, effectively transmitting the weakness to the U.S. economy.

There are other aspects of the NGP Report that merit further discussion, including its approach to adaptive management (we now have three different JRP reports in as many years that take different views on the extent to which AM can be relied upon in making a determination as to the likelihood of significant adverse environmental effects under CEAA), the precautionary principle, species at risk and Aboriginal consultation.

As a result, we may not be able to secure additional financing in a timely manner, or at all, to meet our future capital needs, which may have an adverse effect on our business, operating results and financial condition.

For example, they staged a walk - out at COP19 at Warsaw when their proposal for a loss and damage mechanism, which would contribute to addressing damages occurring from adverse effects of climate change, did not receive enough traction.

IF THE COMPANY BELIEVES, IN ITS SOLE DISCRETION, THAT ANY INDIVIDUALS OR ENTITIES OWNING CTK CREATES MATERIAL REGULATORY OR OTHER LEGAL RISKS OR ADVERSE EFFECTS FOR THE COMPANY AND / OR CTK, THE COMPANY RESERVES THE RIGHT TO: (A) BUY ALL CTK FROM SUCH CTK OWNERS AT THE THEN - EXISTING MARKET PRICE AND / OR (B) SELL ALL CRYPTOCURRENCY ASSETS OF THE COMPANY.

I too at one time used to only associate eastern meditation practices with peaceful Buddhist monks but my experiences made me aware that some persons who engage in eastern meditation practices (which tend to be deep and intense) also experience adverse effects just as I did.

We believe that imposing this burden on our men and women in uniform would undermine recruiting and retention, impact leadership at all levels, have adverse effects on the willingness of parents who lend their sons and daughters to military service, and eventually break the All - Volunteer Force.

The adverse effects of malnutrition increase the body's exposure to infection while at the same time decreasing its ability to fight the infection.

But by making your own protein - powered, coffee - free lattes at home, you'll get all the deliciousness and energy with none of the adverse effects.

Mr Franich said if the About Life lease was transferred to Harris Farm, some customers who would have shopped at Woolworths may also do some or all of their grocery shopping at Harris Farm and that could have an adverse effect on the trading of the Woolworths supermarket store.

Over the years, data revealed that dietary saturated fatty acids (SFAs) are not associated with CAD and other adverse health effects or at worst are weakly associated in some analyses when other contributing factors may be overlooked.

Based on this review, they concluded that the general population of healthy adults is not at risk for potential adverse effects from caffeine if they limit their consumption to 400 mg per day.

It is derived from a fruit that has been consumed in China for at least several hundred years and used as an herbal medicine for the past several decades, so it may well be safe, although any chronic adverse effects might easily have escaped detection.

With Inter continuing to battle for a Champions League spot this season, it remains to be seen if failure to book a place at Europe's top table has an adverse effect on their ability to keep him at the San Siro, but according to Calciomercato the fear of losing him is growing.

Gary Monk deserves plenty of plaudits for the job he's done at Swansea, but the departure of Wilfried Bony has clearly had an adverse effect.

If a player is encouraged — and the pressure at some clubs can be heavy and unpleasant — to play against his wishes it can have an adverse effect on his concentration.

So, whereas I was of the opinion that heading into Monday's encounter no longer top of the league would have a negative effect on the team, it will instead empower them with so much reassurance and positivity that any sort of result would be enough to keep them on course for the title, but it does also mean they're there to be shot at so don't be at all surprised if United come sprinting out of the blocks this evening and put the Gunners to the sword very early on as don't forget, United had top - spot stolen away from them because of the recent bout of adverse weather.

One of the most important and influential studies of the long - term effects of childhood stress and trauma is the Adverse Childhood Experiences study, which was conducted in the 1990s by Robert Anda, a physician at the Centers for Disease Control and Prevention, and Vincent Felitti, the founder of the department of preventive medicine at Kaiser Permanente, the giant health - maintenance organization based in California.

Chemicals with estrogenic activity «have been reported to have potential adverse health effects in mammals, including humans, especially in fetal and infant states,» says Dr. George Bittner, a professor of neurobiology at the University of Texas at Austin who has served on many National Institutes of Health panels.

«I think parents who feed their children formulas, whether soy or milk, should not worry about any adverse effects,» senior researcher Thomas M. Badger, a professor at the University of Arkansas for Medical Sciences in Little Rock, said in an email.

On the one hand, there appears to be a growing body of research suggesting that playing contact or collision sports for a long period of time likely has, at least for some unknown percentage of athletes, serious adverse health consequences, not just from concussions but from the cumulative effect of sub-concussive blows to the head, blows which athletes in youth football, lacrosse, and, until recently, hockey, suffer on an almost constant basis in both games and practices.

«A growing body of research points to the potential for arsenic to cause adverse health effects at low levels.

And while the data is largely inconclusive at this point, it certainly has not eliminated the possibility that too much technology - use could have adverse health effects down the road.

It is thought, however, that levels of these fatty acids at levels greater than those found in human breast milk may have adverse effects on growth, survival, and neurodevelopment in other animals.

In the last few decades it has been established beyond any reasonable doubt that bioeffects and some adverse health effects occur at far lower levels of RF... exposure where no heating... occurs at all; some effects are shown to occur at several hundred thousand times below the existing public safety limits where heating is an impossibility.»

And regarding the non-thermal effect, they hold that «to date, research does not suggest any consistent evidence of adverse health effects from exposure to radiofrequency fields at levels below those that cause tissue heating.»

Yet I know many women who've given birth at home with no adverse effects on themselves or their babies.

In this particular study, any other I've looked at, there was no adverse effects seen but, there is a potential.

In addition, there was no effect on breastfeeding duration when the pacifier was introduced at 1 month of age.280 A more recent systematic review found that the highest level of evidence (ie, from clinical trials) does not support an adverse relationship between pacifier use and breastfeeding duration or exclusivity.281 The association between shortened duration of breastfeeding and pacifier use in observational studies likely reflects a number of complex factors such as breastfeeding difficulties or intent to wean.281 A large multicenter, randomized controlled trial of 1021 mothers who were highly motivated to breastfeed were assigned to 2 groups: mothers advised to offer a pacifier after 15 days and mothers advised not to offer a pacifier.

Dr. Sachs: Caution is advised for nursing women using narcotic pain relievers because of the potential for adverse effects in nursing infants, and some are not recommended at all for use in nursing women because they are concentrated in breast milk.

In addition to being more highly exposed to As, children appear to be far more sensitive to the potential carcinogenic effects of As49, 50 and have a heightened risk for adverse growth, adverse immune response, and adverse neurodevelopmental outcomes,25,51 - 53 even at relatively low levels of exposure.24, 54 Our results indicate that consumption of rice and rice products increases infants» exposure to As and that regulation could reduce As exposure during this critical phase of development.

Chemicals having estrogenic activity (EA) reportedly cause many adverse health effects, especially at low doses in babies and children.

Believing the old word of mouth that having dental treatment during pregnancy can have adverse effects on the health of your baby, is exactly what will put you and your baby at risk.

«A ban of polystyrene foam is going to have an adverse effect on the economy immediately, to include putting hundreds of upstate manufacturing jobs at risk.

But the adverse effects are mitigated by at least two things:

Speaking on the adverse effects of Social media, Professor Adewale decried the way most students place priority on its usage at the expense of their education.

«If the United States is seen as showing its so - called fist at a moment when the people themselves are speaking out, it could have the adverse effect of rallying those individuals against the United States and not against their government,» the Democrat said.

The product will be applied at a very low concentration and is not expected to cause any adverse health effects.

«Because these two chemicals have similar types of adverse health effects, our recommendation is that folks look at the individual or combined concentrations of PFOA and PFOS and compare that to the 70ppt level.»

For decades there has been some belief that pregnancy has an adverse effect on the course of melanoma, increasing the risk of its development, ability to spread throughout the body, and recurrence, said study coauthor Mark Faries, MD, FACS, who was director of therapeutic immunology at the John Wayne Cancer Institute, Santa Monica, Calif. at the time the study was conducted.