Sentences with phrase «adverse effects of this disease»

Gene therapy is the introduction of part of the reproductive code (gene) into a cell to reduce the adverse effects of a disease process.

The good news is there are no long term adverse effects of this disease, and eventually the disease just disappears.

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

One of the most important and influential studies of the long - term effects of childhood stress and trauma is the Adverse Childhood Experiences study, which was conducted in the 1990s by Robert Anda, a physician at the Centers for Disease Control and Prevention, and Vincent Felitti, the founder of the department of preventive medicine at Kaiser Permanente, the giant health - maintenance organization based in California.

Previous research has shown the adverse health effects associated with suboptimal breastfeeding cost the United States $ 14.2 billion annually (2011 dollars) in pediatric disease, including the costs of 911 child deaths.4

Independent studies have conclusively shown adverse health effects of BPA on the brain and reproductive system, as well as metabolic diseases in laboratory animals.

Exposure to PFOA has been linked to a range of adverse health effects, including cancer and thyroid disease.

While lithium carbonate has been very effective for the treatment of mania in bipolar disorder, and credited for reducing suicides in depressive phases of the disease, patients who take lithium carbonate are often noncompliant because of adverse effects, including hand tremor, diarrhea, vomiting, weight gain and decreased thyroid function.

New findings by a biomedical engineer and his team at the University of Houston (UH) raise hope for a new class of drugs to treat lupus that may not include the long list of adverse risks and side effects often associated with current treatments for this disease.

The treatment involves an innovative use of clinically approved treatments for other diseases, so that, according to the authors, «it shouldn't be associated with adverse side effects.»

«No significant safety concerns or dose - dependent adverse side effects of AVI - 7288 were reported with respect to any safety end point evaluated,» said Michael Wong, M.D., senior medical director for infectious diseases at Sarepta.

The recipients did not suffer from the many common adverse effects of stem transplants, including the grueling graft - versus - host disease, which can cause severe liver damage, rashes, diarrhea and even death.

If people categorized as normal weight have lost weight because of more severe disease, researchers will underestimate the adverse effects of being obese relative to normal weight.

Immunoproteasome inhibition, in contrast, has proved effective in preclinical models of autoimmune diseases and was applied over weeks without obvious adverse side effects.

· evidence indicates that low sodium intake may lead to risk of adverse health effects among those with mid - to late - stage heart failure who are receiving aggressive treatment for their disease;

«If the mouse models are indicative of human disease, the combination therapy can increase the proportion of patients who respond to therapy without additional adverse side effects and can improve the quality of life for cancer patients.»

An international team led by metabolism experts Matthias Tschöp (Helmholtz Zentrum München / Technische Universität Müchen), Richard diMarchi (Indiana University) and Timo Müller (Helmholtz Zentrum München) report in the current issue of the journal Cell that liver - specific delivery of the thyroid hormone T3 using glucagon corrects obesity, glucose intolerance, fatty liver disease and atherosclerosis without causing adverse effects in other tissues.

Although doctors have long incorporated personal information like family history into treatment plans, personalized medicine holds the promise of revolutionizing medical care by using knowledge of molecular biology and genetics that will allow more precise diagnoses, better diagnostic tests, greater predictability of disease course, more successful therapies by targeting the right treatments to the right patients, and improved patient safety by selecting drugs and their proper dosage to reduce adverse side effects.

ASH is alarmed about the opioid crisis; however, it is concerned about potential adverse effects that policy changes could have on the administration of necessary and appropriate pain medicine for patients with hematologic conditions such as sickle cell disease (SCD), blood cancers, and other bleeding disorders.

Secondary prevention trials showed significant adverse effects of n - 6 LA on coronary heart disease mortality (1.84 (1.11 to 3.04); P = 0.02; web appendix, part 8).

In most cases of familial motor neuronopathy, the disease is caused by either gain - of - adverse - effect mutations or partial loss - of - function mutations in ubiquitously expressed genes that serve essential cellular functions.

E-Scape Bio is now developing small - molecule drugs that target the primary genetic cause of Alzheimer's disease by correcting adverse effects of the apolipoprotein E4 (apoE4) gene.

Three recent experimental studies focused on low consumption / exposure.949596 In one study, 29 smokers each consumed a single cigarette, immediately after which they had a significant decrease in blood vessel output power and significant increase in blood vessel ageing level and remaining blood volume 25 minutes later, as markers of atherosclerosis.94 In another study, human coronary artery endothelial cells were exposed to the smoke equivalent to one cigarette, which led to activation of oxidant stress sensing transcription factor NFR2 and up - regulation of cytochrome p450, considered to have a role in the development of heart disease.95 These effects were not seen when heart cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain cells.96

There is unequivocal evidence of serious, adverse effects from over exposure to sunlight in terms of skin cancers and cataracts, but there is also accumulating evidence that sunlight exposure, acting via its role in vitamin D synthesis, can protect against certain diseases.

USC's Dr. Valter Longo has created the Fast Mimicking Diet, a five day partial eating diet that in research decreased risk factors / biomarkers for aging, diabetes, cardiovascular disease, and cancer without major adverse effects, providing support for the use of FMDs to promote healthspan.

27 Studies cited by the 2010 DGAC Report demonstrate varied metabolic responses to lowered dietary saturated fat, with certain subpopulations exhibiting adverse rather than improved health outcomes.3 Two recent comprehensive meta - analyses indicate that saturated fat is not linked to heart disease.28, 29 In fact, in a definitive review of forty - eight clinical trials, with over sixty - five thousand participants, the reduction or modification of dietary fat had no effect on mortality, cardiovascular mortality, heart attacks, stroke, cancer, or diabetes.30 Yet, avoiding saturated fat remains a cornerstone of national dietary guidance.

Having enough levels of these hormones is vital because an imbalance would cause a slew of adverse effects and may even result in serious diseases, such as hyperthyroidism, hypothyroidism, Hashimoto's disease and Graves» disease.

If you suffer from trimethylaminuria, renal disease, liver disease, depression or Parkinson's disease, you might be at risk of adverse effects with choline intakes.

Cordain then asks the hypothetical question: «Would it be surprising that the typical western diet which includes 10 to 12 grams of sodium per day might have adverse effects upon the immune system and diseases of chronic inflammation?»

Moreover, one study that had patients with celiac disease consume properly fermented sourdough bread (which was found to contain < 10 ppm of gluten) for 60 days found that there was no adverse effect on clinical symptoms or intestinal pathology.

46Vitagliano A, Quaranta M, «Empiric» inositol supplementation in normal - weight non insulin resistant women with polycystic ovarian disease: from the absence of benefit to the potential adverse effects, ARCHIVES GYNECOLOGY OBSTETRICS, 2015.

In everyone, when one eats starches it quickly turns to sugar, glucose, fructose, galactose, etc. that will circulate and glycate the collagen that lines the arteries causing inflammation and cardiovascular disease and all of the other adverse effects of glycation.

So, «[E] arly dietary counseling of teenage acne patients is thus a great opportunity for dermatology, which will not only help to improve acne but may reduce the long - term adverse effects of Western diet on more serious [TOR]- driven diseases...»

These adverse effects may contribute to the hallmark symptoms of Alzheimer's disease: impaired memory and ability to learn, reduced ability to make judgments and communicate, and changes in personality and behavior such as anxiety, agitation, and delusions.

The adverse effects associated with long - term, high protein - high meat diets may include disorders of bone and calcium balance, increased cancer risk, disorders of the liver, and worsening of coronary artery disease.

Even though grapefruits alone don't do much, the researchers suggest that people might be more likely to stick with them than cholesterol - lowering drugs, noting that most people with heart disease stop taking their statin drugs within a couple years, because of the adverse side effects, whereas grapefruit alone don't have any side effects.

The only adverse effects of iodine arise in people who have inflammatory thyroid disease, such as Hashimoto's thyroiditis, unsuspected thyroid nodules, or longstanding and severe iodine deficiency.

It does not, however, require full blown celiac disease to suffer from the adverse effects of this protein.

Combined with the stress of exercise, this could be enough to cause adverse effects on heart function in some individuals, especially individuals who have undiagnosed heart disease.

We reported this to the Food Standards Agency, who have taken action to notify Cow & Gate of labelling requirements and issued the following statement: In light of advice from the Scientific Advisory Committee on Nutrition on the adverse effects of trans fats on the risk of coronary heart disease, the Agency welcomes the voluntary action by the UK food industry to reduce the levels of artificial trans fats in our foods.

It does this without slowing down your metabolism or having any adverse effects on your physical and mental performance (like most diets can) and it's even scientifically proven to reduce the risk of diabetes, heart disease, aging, and cancer.

We can help prevent the adverse effect of inflammation and inflammatory diseases, like arthritis, but giving our bodies more of the energy they crave.

I think just kind of looking at some takeaways, the main recommendations is that, kind of the new science is that there is new science showing adverse health effects of low sodium intake, especially among individuals with diabetes, kidney disease, cardiovascular disease, as well as people who are healthy and trying to limit their salt intake because of fear that too much might cause potential problems heart disease wise down the road.

Low - carbohydrate diets also delay the onset of type 2 diabetes, improve the adverse effects of the metabolic syndrome, and ameliorate symptoms of polycystic ovary disease in women.

While coeliac disease is not an allergy, cereals containing gluten is one of the 14 main allergens that are subject to food information regulations across the EU due to its adverse effects on the health of people with coeliac disease.

If your pet is taking medication for a disease condition, ask your veterinarian if side effects of the medicine could be involved with any adverse symptoms such as lack of appetite, vomiting or diarrhea (but DO N'T stop giving prescribed medication until you speak with your veterinarian).

Even more delayed adverse effects include... canine distemper antibodies in joint diseases of dogs.»

Contrary to popular opinion, the vaccine has no more adverse effects than any other vaccine, so if the dog is at risk of contracting the disease, vaccination is wise.

When considering actual costs, the inconvenience of twice daily pilling a cat for life, adverse effects of the medications, progressive cardiomyopathy that we can't resolve with medicine, and considering we are merely suppressing the disease and not curing it, medical management is rarely the best option for treating hyperthyroidism.

Chronic nonspecific therapy may result in adverse effects and allow progression of the underlying disease process leading to an even more difficult to manage situation.