Sentences with phrase «affect cell growth»

They do not kill cancerous or viral cells, but regulate the action of specific genes that control the production of cellular proteins that affect cell growth.

Actually, almost all signalling pathways that affect cell growth and proliferation directly regulate rRNA synthesis, their downstream effectors converging at the Pol I transcription machinery.

Other studies show that visceral obesity raises a person's risk of developing colon cancer, perhaps because it increases circulating levels of hormones that affect cell growth.

Based on analyses of over 600 drug and breast cancer cell pairings, researchers showed that, for some cells, drug exposure can cause significant changes in gene expression — indicating the successful action of a drug on its target — without affecting cell growth or survival.

The research team identified predictive models of transcription — the first step in gene expression — when the yeast cell is responding to osmotic stress (salt), which greatly affects cell growth.

And lab experiments have shown that estrogen may inhibit tumor development in the colon by affecting cell growth, or by lowering levels of a cancer - linked hormone called IGF - 1.

Not exact matches

«In animal studies, exercise has been shown to specifically affect the hippocampus, significantly increasing the growth of new neurons and cell survival, enhancing memory and learning, and increasing molecules that are involved in the plasticity of the brain,» Chaddock said.

In the new study, the scientists expressed surprise that the early abnormal growth of brain cells they observed in the fish embryo specifically affected male hormones, potentially indicating why more boys than girls are diagnosed with certain neurodevelopmental disorders such as autism.

«To my great surprise, even injecting 10 million activated T cells specific to the P1A antigen did not affect tumor growth in this induced tumor model,» says Van den Eynde.

In the lab, they also did an experiment to see if wash water from tunnels affected the protein activity in liver cells, or reduced the growth of an algae called Pseudokirchneriella subcapitata.

However, microgravity can reduce cell growth, alter gene expression and change the pattern of root growth — all aspects which critically affect plant cultivation in space.

The Campàs lab is studying several of these questions, including how limbs are built and how mechanical changes in tumors affect the behavior of malignant cells and the growth of the tumor.

He and colleagues have determined what gives cholera bacteria their curved shape and whether it matters (a polymer protein, and it does matter; the curve makes it easier for cholera to cause disease), how different wavelengths of light affect movement of photosynthetic bacteria (red and green wavelengths encourage movement; blue light stops the microbes in their tracks), how bacteria coordinate cell division machinery and how photosynthetic bacteria's growth changes in light and dark.

To test this hypothesis scientists needed to learn how the sulfide presence in the environment affects the growth of the E. coli bacteria cells, which have only one terminal oxidase (bd - I, bd - II or bo) in the respiratory chain.

Increasing levels of PUMA only affected stem - like cells that were starting to spread and not the growth of primary tumors.

There are several factors that may affect the growth of stem cells based on batch - to - batch media variation,» said Alysson Muotri, PhD, associate professor in the UC San Diego departments of Pediatrics and Cellular and Molecular Medicine.

A key feature of STB is the long symptomless growth of the fungus — called Zymoseptoria tritici — which can affect the host plant's cells before it switches to the visible disease phase that eventually destroys the plant's leaves.

The nanogel didn't adversely affect stem cell growth or function, and the encased stem cells didn't trigger a rejection response.

In a report on their experiments, published April 2017 in the Proceedings of The National Academy of Sciences, the researchers say they found evidence that microglia, a cell type found in most vertebrae innate immune systems, affect the Müller glia's regenerative response and can be harnessed to accelerate the growth of new tissue in the retina.

On the other hand, the optimisation of growth conditions, such as light and temperature, can also affect the compounds produced by the cells — just like in nature.

A few years ago, Manalis and colleagues set out to adapt this technique to predict how cancer drugs affect tumor cell growth.

The yeast cells, he found, had a mutation affecting a growth pathway similar to the defective one in Laron cases.

«You can see they are very active and affect the DNA in the tumor tremendously, causing lots of mutations that may further the cells» uncontrolled growth, says Alon Keinan, a computational biologist at Cornell University.

How cells regulate their size and how cell size affects organism growth are among the remaining mysteries in cell biology.

Samples of tumours from bowel cancer patients given different doses of resveratrol showed that even lower doses can get into cancer cells and potentially affect processes involved in tumour growth.

This inflammation is important in the normal healing process, affecting tissue growth and blood flow changes that allow the tissue to heal; when the inflammation subsides, skin cells start growing to cover the wound and help the tissue knit together.

It is the first time that evidence has been found to suggest that local anaesthetic could affect tooth cell growth and potentially impact upon tooth development.

These analyses showed that Angiopoietin - 2 is not just affecting angiogenesis, but controls at the same time the production of tumor promoting growth factors in endothelial cells.

One aspect of their work studies how cell signaling pathways, such as those that initiate cell growth or death, are affected by the nanostructures and microstructures of implant materials such as titanium.

A study led by Dr. Bing Hu at Plymouth University Peninsula Schools of Medicine and Dentistry and involving other researchers from China and Switzerland, suggests for the first time that the use of local anaesthetic may affect tooth cell growth and the development of children's teeth.

Neurotrophic factors affect the survival and growth of nerve cells.

Ectopic expression of KLF4 alone in 231BrM did not affect the primary tumor growth in vivo and this is due to the fact that the endogenous level of KLF4 in 231BrM cells is already quite high.

To better understand how insulin signaling affects beta - cell growth, the Joslin scientists next studied a pathway involving a protein called FOXM1.

Some of those hits affect tyrosine kinases, enzymes that promote cancer by stimulating abnormal cell growth and proliferation.

It affects the division of cancer cells and can slow tumor growth.

Although triple negative cancer cells lack the three critical genetic markers that are currently used to guide breast cancer treatment, the scientists» analysis suggests a strong reliance on signaling through pathways similar to those that affect fetal breast stem cell growth.

This is a problem because Cas9 expression affects growth rate, so my cell pool is going to evolve over time, which is bad news for repeatability and bad news for a screen.

When the gene is mutated or missing, as it is often observed to be in a host of cancers, growth signals affecting cells can get stuck in the «on» position, enabling cells to proliferate out of control.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

We furthermore proved that the GM - CSF / Lyn / Stat3 pathway that contributes to growth of leukemic cells could be profoundly affected, by using a new plasma membrane disrupting agent, which rapidly delocalized CD45 away from lipid rafts.

Understanding the conditions that cause these cells to go off to different fates may have a bearing on health problems such as ectopic pregnancy, which occurs when the embryo develops outside of the womb in about 1 of 60 pregnancies, or molar pregnancy, which is abnormal tissue growth within the uterus that affects about 1 in every 1,000 pregnancies.

This innovative treatment utilizes adult stem cells (from your body fat) which have the ability to decrease inflammation, repair damaged tissue, facilitate better cell - to - cell communication and stimulate new blood vessel growth for better blood flow to the affected area (s).

CREBBP (CBP) and EP300 are general transcriptional co-activators, which are involved in many biological processes like maintenance of genomic stability by affecting DNA replication and DNA repair as well as cell growth, transformation and development.

Until now, lincRNAs have been studied primarily in cell lines rather than at the organismal level, which has precluded research into how lincRNAs affect growth and development.

By affecting the rate of cell differentiation and gene expression, thyroid hormones regulate the growth and migration of neurons, including synaptic development and myelin formation in specific brain regions.

Regardless if it was in a lab, the fact that these vegetables affected the cancer cells themselves, to the extent of stopping the growth, sends a powerful message.

While the mechanisms by which these compounds prevent cancer is not yet fully understood, the compounds might help remove or neutralize carcinogens or affect your body's hormone levels to prevent hormone - related cancers, or they might simply change how your cells grow to prevent the uncontrolled growth seen in cancer.

When a person is affected with plaque psoriasis, their skin cells have an accelerated growth with lots of premature (not fully developed) skin cells coming to the surface, forming thick skin plaques.You can read a lot more here about psoriasis.

Inflammation has been shown to affect the health of the heart and arteries, nerve cells, the brain, and may even affect cellular growth.

Intermittent fasting may also promote new nerve cell growth, which can positively affect cognitive function.