Sentences with phrase «affect cellular function»

Because psychiatric diseases predominantly affect cellular function in the brain, it can be hard to get a clear picture of exactly what is being affected at the molecular level.

But these molecules have been difficult to study, and Tavazoie's team wanted to know if changes in the amount of tRNAs can affect cellular function.

Classic SMLM requires high overexpression of target proteins in order to achieve sufficient density to fulfill the Nyquist criterion, which may affect cellular functions and morphologies.

Rhamnazin has also shown protective properties against inflammation in acute lung injury, inhibiting the metabolism of cytokines, which are proteins secreted by the immune system in order to affect cellular functions.

Not exact matches

Leading clinical investigations seeking to address cardiovascular risk reduction beyond lowering LDL - C focus on interrupting the atherosclerotic process (e.g., plaque formation and instability) by beneficially affecting other lipid, lipoprotein and inflammation biomarkers and cellular functions thought to be related to atherosclerosis and cardiovascular events.

Some autopsy data shows that infants of smokers have signs of established hypoxic - ischemic cellular injury in the brain and the heart which probably occurred in antenatal life, may have been caused by suboptimal placental function and may have been sub-clinical, but if the baby continues to be in a vulnerable environment exposed to post-natal passive smoking, this could affect autonomic nervous system function and lead to poor temperature control, and poor heart rate and respiration control.

The affected mitochondria could no longer provide the synapses with enough energy, which ultimately prevented the synapses from functioning — providing the first direct link between cellular injury caused by amyloid protein and the characteristic breakdown of neuronal communication that occurs in Alzheimer's patients.

These data demonstrate that in RNA's with very different cellular functions, there are domains with similar structural and functional properties and that there is a nucleotide in M1 RNA that affects the site of cleavage by the enzyme.

«Because many broadly expressed genes that play key roles in essential cellular functions are under the control of cell - specific enhancers, the ability to affect enhancer function by knocking down eRNAs could potentially provide a new strategy for altering gene expression in vivo in a cell - specific manner,» said Glass, noting that in his research, anti-sense oligonucleotides were developed in conjunction with Isis Pharmaceuticals, which suppressed enhancer activity and reduced expression in nearby genes.

The goal of the NIH program, as described on its website, is «to understand the principles behind the three - dimensional organization of the nucleus in space and time (the fourth dimension), the role nuclear organization plays in gene expression and cellular function, and how changes in the nuclear organization affect normal development as well as various diseases.»

Our proposed studies will explore the APP molecule as a whole cellular component that could affect brain function and memory processing.

Building on these extreme examples that emphasize the potential roles played by healthy lysosomes in protecting neurons against the age - dependent accumulation of toxic cellular debris, we ultimately seek to understand how neurons sense and regulate the status of their lysosomes, how lysosomes are affected during age - related disease states and whether lysosomal function can be modulated for therapeutic purposes.

Armed with this knowledge, the researchers believe they can determine the cell types, cellular functions and genes that are affected by smoking, and how that varies between healthy and COPD - afflicted lungs.

Over the years the mutations and the cells they affect have led us to study new channel proteins, new transcription factors, neurodegeneration, microtubule function and structure, neuronal outgrowth, insulin signaling, cellular ensheathment, and touch sensitivity to give just a partial list.

To understand the mechanism (s) underlying the MELK function in BBC cells, we examined how inducible shRNA - mediated MELK depletion affects various cellular processes.

Too much stress, overwork, and aggression is an indication of yang excess, which affects your chemistry and physiology all the way down to your cellular functions.

Shrinkage and decreased functions affect the liver, kidneys, and other organs unless the body can maintain a proper ratio of growth hormone which protects them through restorative cellular regeneration.

''... we hypothesize that repeated stress - related allostatic overload may affect brain function at three basic levels: (a) at the cellular level, it may compromise proteostasis (e.g. tau protein), organelles homeostasis, and induce epigenetic changes in neuronal DNA; (b) at the tissue level it may affect intracellular communication (synaptic contacts), number of cells (reduction of neuronal density), composition of the extracellular matrix (accumulation of amyloid plaques), and neuroinflammation; (c) at the systemic levels it may alter the brain's regulation of behavior (cognitive decline).

Aβ is believed to penetrate neuronal plasma membranes, where it leads to lipid peroxidation.10 It has also been implicated in deactivating a subunit of the pyruvate dehydrogenase complex, thereby inhibiting conversion of pyruvate to acetyl CoA and the eventual production of cellular energy as ATP.32 Another way Aβ affects glucose metabolism in the brain is that fragments of Aβ disrupt insulin signaling by binding to neuronal synapses, which alters their shape and function.15, 38 Insulin receptors are abundant at synapses, so if the integrity of the synapse itself has been compromised, the receptors won't function effectively.

If we assist our body with correct diet and lifestyle choices and appropriate remedies, we can support our eliminatory channels to improve their function, and restore and regenerate the cellular matrix of the body without any side affects.

Knowing how critical for the proper body function is to maintain blood and cellular fluid at their optimum level of acidity, it is prudent to pay attention to factors that could affect it.

If blood levels of thyroid hormone are affected, low T3 is the most likely result.3 However, T3 can be normal and elevated free fatty acids could still be impairing its cellular function.

He advocates NO olive oil, for example, because of how this affects cellular metabolic functions (not just in the brain but throughout the body).

Affected cats lack an enzyme required to metabolise certain lipids (fats) which means that they accumulate within cells in the body, causing disruption to normal cellular function.

Because of the exquisite specificity in the targeting of IL - 31, other cellular functions and immune responses are not adversely affected.

The cold laser uses a beam of light as it gently passed over the affected area so that the cellular function is increased.

Nutrition can affect both cellular and humoral immune function (Puertollano et al. 2011; Wintergerst et al. 2007).