Sentences with phrase «affect gene»

Downward trends in popular breeds take several years to affect the gene pool, but big year to year changes in rare breeds can have a devastating effect.

His research showed that comprehensive lifestyle changes affect gene expression, «turning on» disease - preventing genes and «turning off» genes that promote cancer and heart disease, as well as the first controlled study showing that these lifestyle changes may begin to reverse aging by lengthening telomeres, the ends of our chromosomes which control aging (in collaboration with Dr. Elizabeth Blackburn, awarded the Nobel Prize in Medicine).

And the soy peptide lunasin is the first dietary ingredient identified to affect gene expression and promote optimal health at the epigenetic level.

It was once assumed that environmental factors took generations to affect a gene change, but research is now finding that a bad enough toxin or environmental stress can alter genes in a single generation.

We have much more ability to affect our gene expression than the mainstream media and the medical community would have us believe.

DNA methylation could play an important role in mediating the effects of DR because it is sensitive to the effects of nutrition and can affect gene expression memory over time.

For instance, a researcher interested in cardiovascular disease could access GTEx data to view all the genetic variants in the human genome that affect gene expression in the heart.

Epigenetic modifications in bacteria, such as DNA methylation, have been shown to affect gene regulation, thereby generating cells that are isogenic but with distinctly different phenotypes.

Based on the study, babies who get less physical contact and are more distressed at a young age, end up with changes in molecular processes that affect gene expression.

These small differences in DNA sequence, or genetic variation, may or may not affect gene function.

Robert Darnell uses high throughput sequencing and other techniques to investigate the proteins that regulate RNA and thereby affect gene expression.

Although they rely on certain assumptions, such as the ability to define which variants truly affect gene function, aggregation tests have another thing going for them.

The field of epigenetics investigates how environment, nutrition and social conditions affect gene expression.

Our colleagues at Gladstone are using this knowledge to search for small molecules that can affect gene regulation and reverse some of the problems caused by the loss of these transcription factors.»

Next, the scientists created cardiac cells missing the same transcription factors to investigate how their interactions affect gene expression.

An interesting question for the future will be the quest for the potential genetic variants that may regulate imprinting levels — iQTLs, analogously to eQTLs that affect gene expression levels.

However, little is currently known about how death and the length of the post-mortem cold ischemia interval specifically affect gene expression since most existing reports are based on very few genes, tissues or individuals5, 6,7,10,11,17,18.

«In the past, there have been all kinds of ideas around how the structure might affect gene control, but now one has been experimentally tested and shown to be true.»

There has been a rapidly increasing interest in whether environmental factors modulate the establishment and maintenance of epigenetic modifications, and thereby affect gene expression and phenotype in humans and wildlife.

Compared with the ancestral lineage, the East African cichlid genomes possess: an excess of gene duplications; alterations in regulatory, non-protein-coding elements in the genome; accelerated evolution of protein - coding elements, especially in genes for pigmentation; and other distinct features that affect gene expression, such as insertions of transposable elements and regulation by novel microRNAs.

We notably follow the time course of structural changes in response to cues that affect gene expression either transiently or permanently: changes in genome structure during transient hormonal response of differentiated cells and stable trans - differentiation of B cells to macrophages.

It was established that the addition or removal of several small chemical groups to or from DNA could affect gene expression.

A new study in fat cells has revealed a molecular mechanism that controls how lifestyle choices and the external environment affect gene expression.

For now, Stadler's team wants to focus on the regions in which it found altered gene numbers to see how the CNVs affect gene and protein functions.

Ishii and his team chose to focus on two histone variants named TH2A and TH2B, known to be specific to the testes where they bind tightly to DNA and affect gene expression.

Our work illuminates how short chain fatty acids contribute to the regulation of proteins that package the genome and, thus, they affect gene activity.»

While the study represents a strong start for understanding how eQTLs affect gene regulation and expression, Engelhardt pointed out that she and her colleagues still do not have enough samples to understand trans - eQTLs as deeply as they would like.

Chromatin is the protein packaging that helps regulate genome function by controlling access to DNA; changes in this packaging can affect gene regulation.

Surprisingly, no one seems to have studied this family or their interesting mutation from a biophysical perspective or toward the goal of how the mutation might affect the gene - regulatory properties of SRY.»

«Experience and environmental stimuli appear to almost constantly affect gene expression and function throughout the brain.

In two new studies, a team of researchers led by Eva Nogales, senior faculty scientist in the Molecular Biophysics and Integrated Bioimaging (MBIB) Division, has gained insight into the structure of PRC2 and the ways in which it is regulated to affect gene silencing.

Their work also sheds new light on how heredity and environment can affect gene expression.

The researchers performed a «genome - wide» study in children with newly diagnosed CD, before any treatment, to look for possible epigenetic changes that may affect gene behavior.

George Bray, who heads the clinical obesity and metabolism department at Louisiana State University, says environment and behavior — like lack of access to exercise facilities and overeating — so strongly affect gene activity that you can not focus on one while ignoring the other.

The new work, published today in Cell Reports, finds that the protein ADR - 1 binds to messenger ribonucleic acid, or mRNA, and then enhances RNA editing, a process that allows a gene to be present as multiple mRNAs that can then each affect gene expression differently.

The answer may lie in epigenetics — the mechanism by which environmental influences affect gene expression.

Now, new research suggests changes at the epigenetic level — specifically alterations in proteins that affect gene expression, rather than genetic mutations — could be driving childhood ependymomas.

Now everything we do — everything we eat or smoke — can affect our gene expression and that of future generations.

They examined whether there were differences in the composition of the breast milks» microRNAs, snippets of RNA that affect gene expression and can be passed to the infant.

Strangely enough, former lovers somehow make an imprint on the brain and possibly affect genes, especially if there was past fluid exchange.

For Molly Schumer, a postdoctoral fellow in genetics and evolutionary biology at Harvard Medical School, the fellowship will help fund her research on how evolutionary forces affect our genes, focusing in particular on a persistent trait that can cause melanoma in swordtail fish.

Analysis of affected genes revealed possible functional effects from 532 of the mutations.

It involves the addition of a methyl group to DNA that changes the way genes are transcribed and affects gene expression.

The researchers also found that four of the affected genes in the hippocampus and one in leukocytes are similar to genes in humans that are linked to PTSD.

If they could find an affected gene in the boy's family, it might lead researchers to the causes of more common, sporadic cases of Beckwith - Wiedemann, too.

The erasure is imperfect, and sometimes the affected genes may make it through to the next generation, setting the stage for transmission of the altered traits in descendants as well.

Indeed, the group found that the affected gene, named left - right dynein (lrd), comes on in the «node» — a key source of patterning signals — just before the appearance in the mouse embryo of the first known left - right asymmetries, the left - sided expression of two genes called nodal and lefty.

So the less the better when it comes to transcribing the affected gene.

Methylation is among the so - called epigenetic processes — those not specifically designed to affect the genes — that can alter chromatin.

The environmental factors also affected gene expression in the brain.