Sentences with phrase «affect myocardium»
Although medical and surgical treatments available today for the ischemic heart disease patients diminish the risk of acute myocardial infarction and reduce to some extent the incidence of recurrent heart attack, one of the unsolved challenges is to affect myocardium remodeling occurring during ischemic heart failure.
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Stem cells affect the infarcted myocardium via neovascularization, reduction of apoptosis and paracrine effect, they are able to increase myocardial perfusion, inhibit synthesis of pro-inflammatory cytokines (IL6 and TNFα) and promote expression of anti-inflammatory cytokines (IL10) minimizing the necrosis damage caused by local inflammatory reaction.