Trans fats might
affect systemic inflammation through incorporating into endothelial cell membranes (36), activating cell - specific pathways (37), and affecting macrophage membrane phospholipids (38).
It seems that saturated fats
affect systemic inflammation through inducing nuclear factor κB activation and expression of Cox - 2 through Toll - like receptor 4 (35).
Not exact matches
One prevailing theory is that both conditions are a consequence of
systemic inflammation, an inflammatory state that
affects multiple organs and can lead to life - threatening conditions.
Although there are many different types of autoimmune diseases and they can
affect many different organs, at their core they are all similar in that they are an immune response caused by
systemic inflammation that leads your body to attack itself.
Dr. Tolaymat, who is affiliated with the Mayo Clinic in Jacksonville, Florida, says the shift can be credited to the recognition that psoriasis and psoriatic arthritis are inflammatory conditions, and that low - grade,
systemic inflammation can
affect other parts of the body — mainly the vascular system.
This leads to
systemic inflammation affecting the body's organs and soft tissue, including the joints and even the brain.
But
inflammation is also a
systemic phenomenon, meaning it
affects the whole body.
Systemic lupus erythematosus (chronic
inflammation affecting heart, joints, skin, lungs, blood vessels, liver, kidneys, and nervous system)
Release of active pancreatic enzymes and inflammatory mediators from the infl amed pancreas, such as Tumor Necrosis Factor - α (TNF - α) interleukin - 1 (IL - 1) and phospholipid platelet activating factor (PAF), amplifies the severity of pancreatic
inflammation, and adversely
affects the function of many organs (
systemic inflammatory response), and cause derangement in fl uid, electrolyte and acid - base balance.
It is thought that disease results from the combination of an abnormal gene (causing an abnormal structure of the SAA protein), and also infectious or environmental factors that cause
systemic inflammation and so increase the production of this protein in
affected cats.
Some severely
affected dogs also need lifetime
systemic medication (oral) to help control
inflammation, and / or glaucoma medication to attempt to control glaucoma.