How do the expectations or life legacy of fathers
affect their offspring in this story?
Most
the affected offspring in these litters had choroidal hypoplasia.
Not exact matches
If an individual acquires a character during its lifetime, that does not increase the probability that its
offspring will exhibit the character; but if the development of some members of a population are
affected by the environment
in ways which improve their chance of leaving
offspring, this will obviously increase their contribution to later generations, that is to say, their natural selective value; and the frequency of that character
in later generations will be increased, not by any physiological or genetical change, but by the operation of selection.
To see how the new habitats
affected these populations, evolutionary ecologist Alexander Badyaev of Auburn University
in Alabama and colleague Geoffrey Hill tagged thousands of birds at each site and followed their
offspring from hatching through adulthood.
Adult
offspring exposed
in utero had increased liver fibrosis and inflammation, with both male and female mice
affected.
The researchers investigated 16 groups of female and male mice
offspring exposed to maternal diet - induced obesity and male hormone excess and studied how these environmental factors
affected the mice's behaviour as well as gene expression
in the brain.
«Mothers» sleep, late
in pregnancy,
affects offspring's weight gain as adults.»
The process by which a mother's diet during pregnancy can permanently
affect her
offspring's attributes, such as weight, could be strongly influenced by genetic variation
in an unexpected part of the genome, according to research led by Queen Mary University of London (QMUL).
In this case, the model could hold new revelations about how stress during pregnancy could
affect both the mother and her
offspring.
This temporary colonization of E.coli
in the mother
affected the immune system of her
offspring; after birth, the
offspring harbored more innate lymphoid and mononuclear cells
in their intestines compared to mice born to microbe - free pregnant mothers.
A study of the long - lived seabird, the European shag, published
in the journal Functional Ecology shows that parental age may
affect how long
offspring live.
Prof. Ruiling Zhang and team from Xinxiang Medical University explored the correlation between cyclin - dependent kinase 5 expression
in the hippocampus and neurological impairments following prenatal ethanol exposure, and found that prenatal ethanol exposure could
affect cyclin - dependent kinase 5 and its activator p35
in the hippocampus of
offspring rats.
Maternal alcohol consumption prior to and during pregnancy significantly
affects cognitive functions
in offspring, which may be related to changes
in cyclin - dependent kinase 5 because it is associated with modulation of synaptic plasticity and impaired learning and memory.
But because the vinclozolin - induced fertility changes occurred
in almost every male rat descended from a treated mother rather than
in a small percentage of
offspring (as is seen
in germ line mutations caused by radiation), Skinner suspects an epigenetic mechanism — a change that doesn't mutate the DNA sequence of an animal, but rather
affects how genes are expressed.
Here, we used parentage analysis with multilocus microsatellite markers to measure how varying levels of genetic introgression with non-native rainbow trout (Oncorhynchus mykiss)
affect reproductive success (number of
offspring per adult) of native westslope cutthroat trout (Oncorhynchus clarkii lewisi)
in the wild.
After analyzing news coverage levels, the researchers administered a survey
in March 2013 to 822 new and expectant mothers to determine if they incidentally encountered, or «scanned,» news about chemicals
in the prior 6 months and how such scanning was related to their behavior to reduce chemical exposures that might
affect their
offspring.
Thus, placental function appears to be
affected differently for male or female
offspring, potentially framing sex differences
in metabolic, immunological, and inflammatory responses (186).
How these interactions could
affect reproduction
in the herbivores and impact their
offspring are exciting directions for future research, he adds.
Furthermore, lower high - density lipoprotein (HDL)- cholesterol was seen
in female
offspring, if both parents were
affected with diabetes.
Throughout literature, GDM is associated with several adverse pregnancy outcomes
affecting not only mothers but also their
offspring in a sex - specific way (87, 88).
This study describes for the first time that suboptimal IVC
affects male fertility and that a paternal IVC effect induces intergenerational transmission of a glucose metabolism alteration and hepatomegaly phenotype to their male
offspring, confirming that programming events triggered by preimplantational growth restrictions may induce persistent and transmissible phenotypic abnormalities
in subsequent generations.
«
In this study, biological offspring with two previous generations affected with major depression were at highest risk for major depression,» concluded a team led by Myrna Weissman of Columbia University and the New York State Psychiatric Institute, in New York Cit
In this study, biological
offspring with two previous generations
affected with major depression were at highest risk for major depression,» concluded a team led by Myrna Weissman of Columbia University and the New York State Psychiatric Institute,
in New York Cit
in New York City.
What we are learning is that the
in utero environment may also
affect the timing of future pubertal development
in offspring, which makes sense since human brains are developed
in utero and the brain releases hormones
affecting puberty,» said study lead author Ai Kubo.
The results from these studies suggest that maternal antibodies targeting the brain can
affect brain development
in their
offspring, resulting
in altered cognition, behavior and motor skills.
Mating; fertility; gestational indices; ovarian primordial follicle counts; estrous cyclicity; precoital interval; gestational length;
offspring sex ratios; postnatal survival; nipple / areolae retention
in preweanling males; epididymal sperm number, motility, and morphology; daily sperm production; and efficiency of daily sperm production were not
affected at any exposure.
If screening detects that a dog is predisposed to a genetic disease (or likely to produce
affected offspring) and / or perhaps already
in the early stages of the disease, then no breeding can take place under the scheme.
In addition, don't breed
offspring or littermates of
affected dogs.
It is not a matter of simply avoiding Cyd and Jordan
in a pedigree, as there are many unidentified carriers
in the breed, and at present it is not possible to identify a carrier, unless it has produced an
affected offspring.
The occurrence of renal disease
in young Shih - Tzu puppies and the fact that usually more than one puppy
in a litter and
in some instances, the entire litter is
affected leads us to suspect it is inherited and that every effort should be made by Shih - Tzu breeders to avoid breeding any stock whose former
offspring have been
affected.
In order to avoid producing crd2 -
affected offspring, at least one dog of any breeding pair should be homozygous Normal / Clear (See chart below).
They are
in need of blood samples from PRA
affected dogs, their littermates, parents and / or
offspring.
In the Cocker spaniel we have found that the risk of getting
affected offspring increases when one or more parents are
affected by distichiasis, suggesting the accumulation of presumed predisposing genes.
In order to avoid producing
affected offspring, carriers of the rcd1b mutation should never be bred to other carriers or to
affected dogs (see chart below).
The relative risk (RR) of producing
affected offspring was found to increase with the number of
affected parents
in the breeding combination.
The heritability of distichiasis was estimated according to methods described for threshold characters -LRB-[14]-RRB- and found to be
in the range of 0.22 - 0.51 depending on whether the estimate was based on the
offspring from matings between one
affected and one healthy parent or matings between two
affected parents.
I.e.,
in offspring produced by one
affected and one unaffected parent the relative risk was 1.3 times higher compared to the risk
in offspring produced by two unaffected dogs.
In offspring produced by two
affected dogs the relative risk was 1.4 times higher compared to
offspring from the previously mentioned mating combination and 1.8 times higher compared to
offspring produced by two unaffected dogs.
Only 3 of the
affected dogs had an
affected parent, and breedings between an
affected and an unaffected parent could produce either all unaffected
offspring or a mix of
affected and unaffected
offspring in the same litter.
It is important to never breed two dogs together that carry one or more copies of the mutation,
in order to avoid producing
offspring that are
affected with BFJE.
They also live
in harsh conditions and can have a variety of health issues that can
affect the health of their
offspring.
Test breeding of epileptic dams and sires done by veterinary researchers have produced incidences of epilepsy
in the
offspring ranging from between 38 % (
affected to nonaffected) to 100 % (breeding together of two
affected dogs).
In some Burmese families, > 10 % of the
offspring are
affected (14).
In the miniature schnauzer, a swallowing condition is inherited but appears to be complex with some, but fewer,
affected offspring from outcross breedings (Cox et al., 1980).
Professor Bedford's advise at that time was:
In general to contain the problem, would be DO NOT BREED from the
affected dog, its parents, its siblings or its
offspring.
In subsequent generations a carrier mated to a carrier, say, Cockapoo to Cockapoo (known as the F2 generation) could produce
offspring which are
affected by the recessive disease.
In the case of recessive mutations,
affected dogs — those with two copies of the mutation — should not be bred if there are serious quality - of - life or financial issues because all
offspring will have at least one copy of the mutation.
The people whose pets are producing unwanted
offspring are seldom people who license their pets
in the first place, so increasing license fees will not
affect them.
Roughly the same situation occurs with a dominant disease that has a post - reproductive age of onset, since as many as half of the
offspring of an
affected dog will become afflicted
in their lifetime, but not until they have passed on the disease gene to half of their
offspring.
This means that, although the condition can be ameliorated
in most cases with the proper treatment, the
affected dog will always remain a carrier of the disease for the rest of its life and it can transmit the condition to its
offspring.
Conversely, if the disease gene is rare
in a breed, it is improbable that
affected offspring will result, though it would be more likely when line - breeding than outcrossing.