A few years ago, Manalis and colleagues set out to adapt this technique to predict how cancer drugs
affect tumor cell growth.
Not exact matches
«To my great surprise, even injecting 10 million activated T
cells specific to the P1A antigen did not
affect tumor growth in this induced
tumor model,» says Van den Eynde.
The Campàs lab is studying several of these questions, including how limbs are built and how mechanical changes in
tumors affect the behavior of malignant
cells and the
growth of the
tumor.
Increasing levels of PUMA only
affected stem - like
cells that were starting to spread and not the
growth of primary
tumors.
«You can see they are very active and
affect the DNA in the
tumor tremendously, causing lots of mutations that may further the
cells» uncontrolled
growth, says Alon Keinan, a computational biologist at Cornell University.
These analyses showed that Angiopoietin - 2 is not just
affecting angiogenesis, but controls at the same time the production of
tumor promoting
growth factors in endothelial
cells.
Ectopic expression of KLF4 alone in 231BrM did not
affect the primary
tumor growth in vivo and this is due to the fact that the endogenous level of KLF4 in 231BrM
cells is already quite high.
It
affects the division of cancer
cells and can slow
tumor growth.
Mast
cell tumors are
growths that most commonly
affect the skin, but may also infiltrate the spleen and liver.
And lab experiments have shown that estrogen may inhibit
tumor development in the colon by
affecting cell growth, or by lowering levels of a cancer - linked hormone called IGF - 1.